Neuromodulatory effects induced by the association of Moringa oleifera Lam., Tribulus terrestris L., Undaria pinnatidifida extracts in the hypothalamus
Chem Biodivers. 2024 Mar 25:e202302075. doi: 10.1002/cbdv.202302075. Online ahead of print.ABSTRACTThe present study investigated the role of a commercial formulation constituted by herbal extracts from Rhodiola rosea, Undaria pinnatifida, Tribulus terrestris, and Moringa oleifera. The formulation was analysed for determining the content in total phenols and flavonoids and scavenging/reducing properties. The formulation was also tested on isolated mouse hypothalamus in order to investigate effects on serotonin, dopamine, neuropeptide Y (NPY), and orexin A. The gene expression of gonadrotopin releasing hormone (GnRH) was al...
Source: Chemistry and Biodiversity - March 25, 2024 Category: Biochemistry Authors: Annalisa Chiavaroli Simonetta Cristina Di Simone Alessandra Acquaviva Nilofar Nilofar Maria Loreta Libero Luigi Brunetti Lucia Recinella Sheila Leone Giustino Orlando Gokhan Zengin Maura Di Vito Luigi Menghini Claudio Ferrante Source Type: research
Synthesis of Cycloartan-16 β-ol from 16β 24R-Epoxy-Cycloartane and their Cytotoxicity Evaluation against Human Cancer Cell Lines
Chem Biodivers. 2024 Mar 23:e202301346. doi: 10.1002/cbdv.202301346. Online ahead of print.ABSTRACTIt was found that Argentatins A and B triterpenoids make up approximately 20-30% of the waste resin produced from the industrial processes to isolate rubber from P. argentatum. We have developed an efficient protocol for synthesizing cycloartane-16β-ol derivatives by opening the oxepane ring of argentatin B acetate (2) with BF3-OEt2. Although three new cycloartenol derivatives showed high cytotoxicity against PC-3 and HCT-15 cancer cell lines, nevertheless, the best results were obtained for (16b,24R) -(16,24-epoxy-cycloarta...
Source: Chemistry and Biodiversity - March 23, 2024 Category: Biochemistry Authors: Atzin Hern ández-Flandes Sim ón Hernández-Ortega Teresa Ram írez-Apan Noem í Silva-Jimenez Leticia Rocha-Zavaleta Mariano Martinez-Vazquez Source Type: research
Synthesis of Cycloartan-16 β-ol from 16β 24R-Epoxy-Cycloartane and their Cytotoxicity Evaluation against Human Cancer Cell Lines
Chem Biodivers. 2024 Mar 23:e202301346. doi: 10.1002/cbdv.202301346. Online ahead of print.ABSTRACTIt was found that Argentatins A and B triterpenoids make up approximately 20-30% of the waste resin produced from the industrial processes to isolate rubber from P. argentatum. We have developed an efficient protocol for synthesizing cycloartane-16β-ol derivatives by opening the oxepane ring of argentatin B acetate (2) with BF3-OEt2. Although three new cycloartenol derivatives showed high cytotoxicity against PC-3 and HCT-15 cancer cell lines, nevertheless, the best results were obtained for (16b,24R) -(16,24-epoxy-cycloarta...
Source: Chemistry and Biodiversity - March 23, 2024 Category: Biochemistry Authors: Atzin Hern ández-Flandes Sim ón Hernández-Ortega Teresa Ram írez-Apan Noem í Silva-Jimenez Leticia Rocha-Zavaleta Mariano Martinez-Vazquez Source Type: research
Pulvinic Acid Derivative Pigments in Lanmaoa asiatica and L. macrocarpa
Chem Biodivers. 2024 Mar 21:e202301996. doi: 10.1002/cbdv.202301996. Online ahead of print.ABSTRACTLanmaoa asiatica G.Wu & Zhu L.Yang and L. macrocarpa N.K.Zeng,H.Chai&S. Jiang are two important gourmet bolete in China, and locally named "Jian Shou Qing" meaning their fruiting bodies turn blue after bruising. The genus represents a distinct lineage in Boletaceae. The pigment(s) associated with the discoloration in Lanmaoa has not been identified. The aim of this study was to determine the pigment(s) underpinning the bluing reaction of L. asiatica and L. macrocarpa when bruised. Potential compounds were isolated by ...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Yixiao Wang Yunjiao L üli Xuan Li Zhuliang Yang Hong Luo Source Type: research
Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
Synthesis and in vitro anti-inflammatory activity of novel dendrobine amide/sulfonamide derivatives
Chem Biodivers. 2024 Mar 21:e202400030. doi: 10.1002/cbdv.202400030. Online ahead of print.ABSTRACTA traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities in vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96 μM. Western bl...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: ZiWei Jiao HanFei Liu KaiQin Lin GuangTong Xie HuaYong Lou WeiDong Pan MaoSheng Zhang Source Type: research
Chemical Composition, Repellent, and Phytotoxic Potentials of the Fractionated Resin Essential Oil from Araucaria heterophylla Growing in Tunisia
Chem Biodivers. 2024 Mar 21:e202400185. doi: 10.1002/cbdv.202400185. Online ahead of print.ABSTRACTThe resin essential oil (REO) of Araucaria heterophylla trunk bark was investigated for its chemical composition. Then, it was evaluated for its insecticidal and allelopathic activities. The REO was obtained by hydrodistillation for 9 h (yield of 4.2% w/w). Moreover, fractional hydrodistillation was carried out at 3-hour intervals, resulting in 3 fractions (R1-R3). GC/MS analysis of the obtained samples allowed the identification of 25 compounds, representing between 91.2 and 96.3% of their total constituents, which consisted...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Oumayma Ben Romdhane Wiem Baccari Ilyes Saidi Guido Flamini Roberta Ascrizzi Ikbal Chaieb Abdel Halim Harrath Hichem Ben Jannet Source Type: research
Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents
This study can act as a beacon for further research in the application of furan-pyrazole and furan-2,4-thiazolidinediones as lead moieties for anti-neuroinflammatory and related diseases.PMID:38513005 | DOI:10.1002/cbdv.202301260 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Sowjanya Mudimela Vijayasree V Giridharan Saravanan Janardhan Source Type: research
Pulvinic Acid Derivative Pigments in Lanmaoa asiatica and L. macrocarpa
Chem Biodivers. 2024 Mar 21:e202301996. doi: 10.1002/cbdv.202301996. Online ahead of print.ABSTRACTLanmaoa asiatica G.Wu & Zhu L.Yang and L. macrocarpa N.K.Zeng,H.Chai&S. Jiang are two important gourmet bolete in China, and locally named "Jian Shou Qing" meaning their fruiting bodies turn blue after bruising. The genus represents a distinct lineage in Boletaceae. The pigment(s) associated with the discoloration in Lanmaoa has not been identified. The aim of this study was to determine the pigment(s) underpinning the bluing reaction of L. asiatica and L. macrocarpa when bruised. Potential compounds were isolated by ...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Yixiao Wang Yunjiao L üli Xuan Li Zhuliang Yang Hong Luo Source Type: research
Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
Synthesis and in vitro anti-inflammatory activity of novel dendrobine amide/sulfonamide derivatives
Chem Biodivers. 2024 Mar 21:e202400030. doi: 10.1002/cbdv.202400030. Online ahead of print.ABSTRACTA traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities in vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96 μM. Western bl...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: ZiWei Jiao HanFei Liu KaiQin Lin GuangTong Xie HuaYong Lou WeiDong Pan MaoSheng Zhang Source Type: research
Chemical Composition, Repellent, and Phytotoxic Potentials of the Fractionated Resin Essential Oil from Araucaria heterophylla Growing in Tunisia
Chem Biodivers. 2024 Mar 21:e202400185. doi: 10.1002/cbdv.202400185. Online ahead of print.ABSTRACTThe resin essential oil (REO) of Araucaria heterophylla trunk bark was investigated for its chemical composition. Then, it was evaluated for its insecticidal and allelopathic activities. The REO was obtained by hydrodistillation for 9 h (yield of 4.2% w/w). Moreover, fractional hydrodistillation was carried out at 3-hour intervals, resulting in 3 fractions (R1-R3). GC/MS analysis of the obtained samples allowed the identification of 25 compounds, representing between 91.2 and 96.3% of their total constituents, which consisted...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Oumayma Ben Romdhane Wiem Baccari Ilyes Saidi Guido Flamini Roberta Ascrizzi Ikbal Chaieb Abdel Halim Harrath Hichem Ben Jannet Source Type: research
Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents
This study can act as a beacon for further research in the application of furan-pyrazole and furan-2,4-thiazolidinediones as lead moieties for anti-neuroinflammatory and related diseases.PMID:38513005 | DOI:10.1002/cbdv.202301260 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Sowjanya Mudimela Vijayasree V Giridharan Saravanan Janardhan Source Type: research
Pulvinic Acid Derivative Pigments in Lanmaoa asiatica and L. macrocarpa
Chem Biodivers. 2024 Mar 21:e202301996. doi: 10.1002/cbdv.202301996. Online ahead of print.ABSTRACTLanmaoa asiatica G.Wu & Zhu L.Yang and L. macrocarpa N.K.Zeng,H.Chai&S. Jiang are two important gourmet bolete in China, and locally named "Jian Shou Qing" meaning their fruiting bodies turn blue after bruising. The genus represents a distinct lineage in Boletaceae. The pigment(s) associated with the discoloration in Lanmaoa has not been identified. The aim of this study was to determine the pigment(s) underpinning the bluing reaction of L. asiatica and L. macrocarpa when bruised. Potential compounds were isolated by ...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Yixiao Wang Yunjiao L üli Xuan Li Zhuliang Yang Hong Luo Source Type: research
Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
