Porphysome Engineered With Specific Protein Binding Sites as a Multimodal Theranostic Nanocarrier for Targeted Protein Delivery
Chem Biodivers. 2024 Apr 14:e202400348. doi: 10.1002/cbdv.202400348. Online ahead of print.ABSTRACTThe immobilization of proteins on the surface of carriers is challenging due to the loss of protein structure and function in this process. Here, we report the development of the protein immobilization on the surface of the metallated-porphyrin complex in the porphysome nanocarrier. The conjugated Ni-porphyrin to fatty acid (as a tail) has been synthesized and independently placed at the depth of the bilayer center of Dipalmitoylphosphatidylcholine (DPPC) in which the Ni-porphyrin was at the polar region of the membrane and i...
Source: Chemistry and Biodiversity - April 14, 2024 Category: Biochemistry Authors: Niloofar Ayyari Zahra Vaezi Zeinab Fotouhi Ashin Elham Karimi Fatemeh Mohsenzadeh Haji Maryam Nikkhah Hossein Naderi-Manesh Source Type: research
Synthesis and Antifungal Activity of Norbornene Carboxamide/sulfonamide Derivatives as Potential Fungicides Targeting Laccase
Chem Biodivers. 2024 Apr 14:e202302033. doi: 10.1002/cbdv.202302033. Online ahead of print.ABSTRACTTo explore more potential fungicides with new scaffolds, thirty-seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound 6e presented excellent in vitro antifungal activity against Sclerotinia sclerotiorum (EC50 = 0.71 mg/L), which was substantially stronge...
Source: Chemistry and Biodiversity - April 14, 2024 Category: Biochemistry Authors: Zi-Hui Yang Yi-Gui Qiu Dao-Jun Jin Yi-Ming Zheng Jia Li Wen Gu Source Type: research
Chemical Composition, Antioxidant, Acute Toxicity and Antinociceptive Activity of Aqueous Extract of Marrubium vulgare L
This study aimed to investigate the chemical composition, acute toxicity, and antinociceptive effects of the aqueous extract from M. vulgare leaves (AEMV). Antioxidant activity was evaluated using DPPH and reducing power assays. The chemical composition of AEMV was determined through LC-MS/MS, and the levels of total phenolics, flavonoids, and condensed tannins were quantified. Acute oral toxicity was assessed in male Swiss mice with a single oral dose of AEMV (1, 2, 5 g/kg). The analgesic impact was examined through writhing, hot plate, and formalin tests. Our findings not only confirmed the safety of the extract in anima...
Source: Chemistry and Biodiversity - April 13, 2024 Category: Biochemistry Authors: Abdelfatah Aitbabaa Hamid Kabdy Abdelmounaim Baslam Hajar Azraida Rachida Aboufatima Loubna El Yazouli Zahra Sokara Stefania Garzoli Abderrahman Chait Source Type: research
Determination of Bacterial Community Structure of Table Olive via Metagenomic Approach in Şarköy
This study is the first study for Şarköy, which is the only table olive production place in the Tekirdağ region due to its microclimate feature. Further studies are needed in more table olive samples from different geographical areas to confirm and develop current findings.PMID:38613509 | DOI:10.1002/cbdv.202302120 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 13, 2024 Category: Biochemistry Authors: Samet U çak Source Type: research
New Antibacterial 1, 3, 4-Thiadiazole Derivatives With Pyridine Moiety
Chem Biodivers. 2024 Apr 12:e202400522. doi: 10.1002/cbdv.202400522. Online ahead of print.ABSTRACT1,3,4-Thiadiazole compounds were synthesized using pyridine carboxylic acid derivatives and thiosemicarbazide derivatives. The molecular structures of the resulting compounds were characterized by spectroscopic methods such as ATR-FTIR, 1H-NMR, and elemental analysis. Its compounds were also examined for their antibacterial properties against some strains of bacteria. Five synthesized compounds showed varying antibacterial effects on Escherichia coli, Salmonella kentucky, Bacillus substilis and Klebsiella pneumoniae. This res...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Nesrin Şener Aiman Emhemad Omeran Aldwib Source Type: research
Protective Effects of Tunisian Orange Co-Product Extract and Oleuropein-Hesperidin Combination on Bleomycin-Induced Pulmonary Fibrosis in Rats
In conclusion, OCE and HO exhibit antifibrotic effects on rat model of pulmonary fibrosis.PMID:38606482 | DOI:10.1002/cbdv.202400251 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Mariem Ben Abdallah Sana Bahri Nahdi Afef Mlika Mona Hadjkacem Linda Jameleddine Saloua Boudhrioua Nourhene Source Type: research
Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5
Chem Biodivers. 2024 Apr 12:e202400507. doi: 10.1002/cbdv.202400507. Online ahead of print.ABSTRACTThree new C10 and C12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.PMID:38606561 | DOI:10.1002/cbdv.20240050...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Hao-Yu Dong Yuan Wang Xiao-Yu Zhang Meng Zhang Long-He Yang Zheng-Biao Zou You Li Ming-Min Xie Xian-Wen Yang Bin Wang Source Type: research
Design, Synthesis, Docking Studies and Molecular Dynamics Simulation of New 1,3,5-Triazine Derivatives as Anticancer Agents Selectively Targeting Pancreatic Adenocarcinoma (Capan-1)
Chem Biodivers. 2024 Apr 12:e202400112. doi: 10.1002/cbdv.202400112. Online ahead of print.ABSTRACTOn the basis of remarkable anticancer profile of s-triazine nucleus, a new series of 2-methoxy-4-(3-morpholino-5-(arylamino)phenoxy)benzaldehyde derivatives 11 a-u was prepared and evaluated for in vitro antiproliferative activity against eight diverse human cancer cell lines (Capan-1, HCT-116, LN229, NCI-H460, DND-41, HL-60, K562 and Z138). Compounds 11 o, 11 r and 11 s were the most potent anticancer agents on pancreatic adenocarcinoma (Capan-1) cell line with IC50 value of 1.4, 5.1 and 5.3 μM, respectively, while compound...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Shazia Asghar Shahid Hameed Najim A Al-Masoudi Bahjat Saeed Amneh Shtaiwi Source Type: research
Active Constituents with Tyrosinase Inhibitory Activities from Waste Tobacco leaves
Chem Biodivers. 2024 Apr 12:e202400463. doi: 10.1002/cbdv.202400463. Online ahead of print.ABSTRACTOne novel compound, (R)-3, 6-diethoxy-4-hydroxycyclohex-3-en-1-one (1) and thirteen known compounds was isolated from the waste leaves of Nicotiana tabacum. The structures of three compounds (1-3) were confirmed and attributed firstly by the extensive spectroscopic data, including 1D/2D NMR, IR, HR-ESI-MS, CD, and ECD spectra. Notably, seven compounds (2, 3, 9, 10, 11, 12, and 13) exhibited better tyrosinase inhibitory activity than the positive control, kojic acid. The binding modes of these compounds revealed that their str...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Shu Zhen Mu Mei Zhang Jia-Yu Sun Hong-Mao Qiu Peng Zhang Lu-Lu Deng Jiang Li Xiao-Jiang Hao Xian-Kun Su Source Type: research
CYTOTOXICITY AND BIOLOGICAL ACTIVITIES OF GEOPOPOLIS EXTRACT FROM THE STINGLESS BEE (Melipona scutellaris) IN CLINICAL ISOLATES OF Staphylococcus aureus
Chem Biodivers. 2024 Apr 12:e202301982. doi: 10.1002/cbdv.202301982. Online ahead of print.ABSTRACTThis work aims to evaluate the biological activities of the EEGP, in order to contribute with a natural therapeutic alternative, to face infections. The EEGP MIC tests showed antibacterial activity against two strains of S. aureus (LPM 63 and LPM 86), both at concentrations of 550 µg/mL. The MBC performed with the inhibition values showed that the EEGP has bacteriostatic activity in both strains. Biofilm inhibition rates exhibited an average value greater than 65% at the highest concentration. The EEGP antioxidant potential ...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Maria Gabriella Borges Luanna Lima Ana Caroline Veras Rafael Ferreira Danielle Alves Isac Medeiros Marciane Magnani Marianna Sobral Ricardo Castro Saulo Tintino Cicera Oliveira-Tintino Henrique Coutinho Felipe Guerra Daniela Barros Maria Bet ânia Oliveir Source Type: research
Investigations of Limeum indicum Plant for Diabetes Mellitus and Alzheimer's disease Dual Therapy: Phytochemical, GC-MS Chemical Profiling, Enzyme Inhibition, Molecular Docking and In-vivo Studies
Chem Biodivers. 2024 Apr 12:e202301858. doi: 10.1002/cbdv.202301858. Online ahead of print.ABSTRACTLimeum indicum has been widely utilized in traditional medicine but no experimental work has been done on this herb. The primary objective of this study was to conduct a phytochemical analysis and assess the multifunctional capabilities of aforementioned plant in dual therapy for Alzheimer's disease (AD) and Type 2 diabetes (T2D). The phytochemical screening of ethanol, methanol extract, and their derived fractions of Limeum indicum was conducted using GC-MS, HPLC, UV-analysis and FTIR. The antioxidant capacity was evaluated ...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Tahira Shamim Hafiz Muhammad Asif Syeda Abida Ejaz Zahid Hussain Tanveer A Wani Laila Sumreen Muhammad Abdullah Zubair Ahmed Jamshed Iqbal Song Ja Kim Muhammad Kamal Shah Source Type: research
Retrobisabolane A, a Novel Bisabolane-Derived Sesquiterpenoid Isolated from Deep-Sea-Derived Fungus Retroconis fusiformis MCCC 3A00792
Chem Biodivers. 2024 Apr 12:e202400805. doi: 10.1002/cbdv.202400805. Online ahead of print.ABSTRACTOne novel bisabolane-derived sesquiterpenoid retrobisabolane A (1), featuring a methyl group location at the C-4 position instead of C-3 in the bisabolanes, and a known ester-substituted eremophilane-type sesquiterpenoid cryptosphaerolide (2), along with three known indole alkaloids (3‒5) were discovered from the fermented cultures of a deep-sea-derived fungus Retroconis fusiformis MCCC 3A00792. The planar structure of new compound 1 was determined by extensive analysis of the NMR and HRESIMS spectra. The relative and absol...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Xin Liu Yinghui Lv Jianlin He Bihong Hong Zongze Shao Miao Yu Siwen Niu Source Type: research
New Antibacterial 1, 3, 4-Thiadiazole Derivatives With Pyridine Moiety
Chem Biodivers. 2024 Apr 12:e202400522. doi: 10.1002/cbdv.202400522. Online ahead of print.ABSTRACT1,3,4-Thiadiazole compounds were synthesized using pyridine carboxylic acid derivatives and thiosemicarbazide derivatives. The molecular structures of the resulting compounds were characterized by spectroscopic methods such as ATR-FTIR, 1H-NMR, and elemental analysis. Its compounds were also examined for their antibacterial properties against some strains of bacteria. Five synthesized compounds showed varying antibacterial effects on Escherichia coli, Salmonella kentucky, Bacillus substilis and Klebsiella pneumoniae. This res...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Nesrin Şener Aiman Emhemad Omeran Aldwib Source Type: research
Protective Effects of Tunisian Orange Co-Product Extract and Oleuropein-Hesperidin Combination on Bleomycin-Induced Pulmonary Fibrosis in Rats
In conclusion, OCE and HO exhibit antifibrotic effects on rat model of pulmonary fibrosis.PMID:38606482 | DOI:10.1002/cbdv.202400251 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Mariem Ben Abdallah Sana Bahri Nahdi Afef Mlika Mona Hadjkacem Linda Jameleddine Saloua Boudhrioua Nourhene Source Type: research
Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5
Chem Biodivers. 2024 Apr 12:e202400507. doi: 10.1002/cbdv.202400507. Online ahead of print.ABSTRACTThree new C10 and C12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.PMID:38606561 | DOI:10.1002/cbdv.20240050...
Source: Chemistry and Biodiversity - April 12, 2024 Category: Biochemistry Authors: Hao-Yu Dong Yuan Wang Xiao-Yu Zhang Meng Zhang Long-He Yang Zheng-Biao Zou You Li Ming-Min Xie Xian-Wen Yang Bin Wang Source Type: research
