GC-MS-based Metabolomics Unravels Metabolites across Larval Development and Diapause of a Specialist Insect
Chem Biodivers. 2024 Mar 1:e202301779. doi: 10.1002/cbdv.202301779. Online ahead of print.ABSTRACTPlant-insect interactions are a driving force into ecosystem evolution and community dynamics. Many insect herbivores enter diapause, a developmental arrest stage in anticipation of adverse conditions, to survive and thrive through seasonal changes. Herein, we investigated the roles of medium- to non-polar metabolites during larval development and diapause in a specialist insect herbivore, Chlosyne lacinia, reared on Aldama robusta leaves. Varying metabolites were determined using gas chromatography-mass spectrometry (GC-MS)-b...
Source: Chemistry and Biodiversity - March 1, 2024 Category: Biochemistry Authors: Mar ília Elias Gallon Eduardo Afonso Silva-Junior Leonardo Gobbo-Neto Source Type: research
Borago officinalis l.: a review on extraction, phytochemical, and pharmacological activities
Chem Biodivers. 2024 Mar 1:e202301822. doi: 10.1002/cbdv.202301822. Online ahead of print.ABSTRACTBorago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post-menopausal symptoms. Its pharmacological properties and biological activities - among them antioxidant, antimicrobial, anticancer, anti-inflammatory, insecticidal, antigenotoxic, and anti-obesity activity - were demonstrated in vitr...
Source: Chemistry and Biodiversity - March 1, 2024 Category: Biochemistry Authors: Slougui Nabila Meriem Slama Akila Benaissa Amine Nekkaa Feriel Sellam Laetitia Canabady-Rochelle Source Type: research
Occurrence and biological activities of seco-iridoids from jasminum l
Chem Biodivers. 2024 Mar 1:e202400254. doi: 10.1002/cbdv.202400254. Online ahead of print.ABSTRACTIn this paper, the first complete review on the seco-iridoids from the genus Jasminum L. was presented. In particular, their occurrence in the genus was detailed together with their biological activities. The literature survey has clearly pointed out that only a few Jasminum species have been studied for their seco-iridoid content evidencing oleoside derivatives as main compounds. In addition, the biological studies performed on them are very scarce focusing mainly on antioxidant and anti-inflammatory assays with modest effect...
Source: Chemistry and Biodiversity - March 1, 2024 Category: Biochemistry Authors: Claudio Frezza Roberta Maria Nicolosi Elisa Brasili Francesco Mura Daniela De Vita Source Type: research
Lycopodium alkaloids from Huperzia goebelii
Chem Biodivers. 2024 Feb 28:e202400209. doi: 10.1002/cbdv.202400209. Online ahead of print.ABSTRACTOne new fawcettimine-type Lycopodium alkaloid，hupertimine F (1), together with five known (2-6) Lycopodium alkaloids were isolated from Huperzia goebelii. The structure of 1 was elucidated by 1D and 2D NMR spectra, HRESIMS, and X-ray diffraction. Structurally, 1 represents the fourth example of Lycopodium alkaloids characterized by a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These known compounds 2, 3, 5, and 6 were isolated from H. goebelii for the first time. Compounds 1-6 were eval...
Source: Chemistry and Biodiversity - February 29, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Bei-Bei Gao Shuai Jiang Wen-Yan Li Yu-Fei Ou Source Type: research
Lachnuoic acids A-F: Ambuic Acid Congeners From A Saprotrophic Lachnum Species Lachnuoic acids A-F: Ambuic Acid Congeners From A Saprotrophic Lachnum Species
Chem Biodivers. 2024 Feb 29:e202400385. doi: 10.1002/cbdv.202400385. Online ahead of print.ABSTRACTChemical prospection of an extract derived from a saprotrophic fungus Lachnum sp. IW157 resulted in the isolation and characterization of six unprecedentedly reported ambuic acid analogues named lachnuoic acids A-F (1-6). Chemical structures of 1-6 were determined based on comprehensive 1D and 2D NMR spectroscopic analyses together with HR-ESI-MS spectrometry. The relative configurations of 1-3 were defined by ROESY spectroscopic analyses while their absolute configurations were unambiguously determined by Mosher's esters met...
Source: Chemistry and Biodiversity - February 29, 2024 Category: Biochemistry Authors: Kunthida Phutthacharoen Rita Toshe Syeda Javariya Khalid Natalia A Llanos-L ópez Jan-Peer Wennrich Hedda Schrey Sherif S Ebada Kevin D Hyde Marc Stadler Source Type: research
New 1H-1,2,4-triazolyl derivatives as antimicrobial agents. Synthesis, biological evaluation and molecular docking
Chem Biodivers. 2024 Feb 29:e202400316. doi: 10.1002/cbdv.202400316. Online ahead of print.ABSTRACTThirteen new 1H-1,2,4-triazolyl derivatives were synthesized, and six of them were selected based on docking prediction for the investigation of their antimicrobial activity against five bacterial and eight fungal strains. All compounds demonstrated antibacterial activity with MIC lower than that of the ampicillin and chloramphenicol. In general, the most sensitive bacteria appeared to be P.fluorescens, while the plant pathogen X.campestris was the most resistant. The antifungal activity of the compounds was much better than ...
Source: Chemistry and Biodiversity - February 29, 2024 Category: Biochemistry Authors: Athina Athanasios Geronikaki Natalia Sucman Eugenia Stingaci Lucian Lupascu Anastasia Smetanscaia Vladimir Valica Livia Uncu Sergiu Shova Anthi Petrou Jasmina Glamo člija Marina Sockovic Fliur Macaev Source Type: research
Antioxidant, cytotoxic, anti-glycation, and anti-tyrosinase compounds from the leaves of Uvaria siamensis
Chem Biodivers. 2024 Feb 29:e202400319. doi: 10.1002/cbdv.202400319. Online ahead of print.ABSTRACTA new oxidized heptene, 7-benzoyloxy-4-hydroxy-1-ethoxy-2E,4Z-heptadiene-1,6-dione, namely siamheptene A (1), together with eight known compounds (2-9), were isolated from the leaves of Uvaria siamensis. Their structures were identified by detailed analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. Compound 9 is reported for the first time from Uvaria genus. Siamheptene A was evaluated for cytotoxicity against HeLa (cervical cancer cells), A549 (lung cancer cells), and Vero cells using the MTT assay an...
Source: Chemistry and Biodiversity - February 29, 2024 Category: Biochemistry Authors: Eakkaluk Wongwad Supachai Jadsadajerm Lapatrada Mungmai Awat Wisetsai Source Type: research
Lycopodium alkaloids from Huperzia goebelii
Chem Biodivers. 2024 Feb 28:e202400209. doi: 10.1002/cbdv.202400209. Online ahead of print.ABSTRACTOne new fawcettimine-type Lycopodium alkaloid，hupertimine F (1), together with five known (2-6) Lycopodium alkaloids were isolated from Huperzia goebelii. The structure of 1 was elucidated by 1D and 2D NMR spectra, HRESIMS, and X-ray diffraction. Structurally, 1 represents the fourth example of Lycopodium alkaloids characterized by a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These known compounds 2, 3, 5, and 6 were isolated from H. goebelii for the first time. Compounds 1-6 were eval...
Source: Chemistry and Biodiversity - February 29, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Bei-Bei Gao Shuai Jiang Wen-Yan Li Yu-Fei Ou Source Type: research
Two new isospirostanol-type saponins derived from the bulbs of Lilium brownii and their anti-hepatocarcinogenic activity
In this study, two new isospirostanol-type saponins were isolated from L. brownii, and their structures were identified by spectroscopic method, and absolute configurations were elucidated by comprehensive analysis of spectral data obtained from combined acid hydrolysis. Two compounds were finally identified as 3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside]-(22R,25R)-5α-spirosolane-3β-ol (1) and 3-O-{α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranoside}-(22R,25R)-5α-spirosolane-3β-ol (2), respectively. Further, we found that compound 2 significantly suppressed the proliferation of SM...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Shuaibo He Tingjuan Wu Yanpo Si Jihong Kang Wenjun Wei Fei Zhang Shuying Feng Jianping Ma Ya Wang Tao Guo Source Type: research
Anti-inflammatory, Antioxidative, and Moisturizing Effects of Oxyceros horridus Lour. Ethanol Extract in Human Keratinocytes via the p38 Signaling Pathway
This study investigates the anti-inflammatory, antioxidant, and moisturizing properties of Oxyceros horridus Lour. (Oh-EE) in human keratinocytes. Oh-EE demonstrates potent antioxidant activity and effectively protects against oxidative stress induced by external stimuli such as UVB radiation and H2O2. Additionally, it exhibits significant anti-inflammatory effects proven by its ability to downregulate the expression of pro-inflammatory cytokines, namely COX-2 and IL-6. The study also explores the involvement of the AP-1 pathway, highlighting the ability of Oh-EE to suppress the expression of p38 and its upstream regulator...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Natasha Christabella Sutopo Laily Rahmawati Lei Huang Masphal Kry Phourin Chhang Sarah Lee Byoung-Hee Lee Jae Youl Cho Source Type: research
Inhibitory Effects of Endemic Thyme's Thymol-Carvacrol Chemotype Essential Oil On Aspergillus Species with Free Radical Scavenging Properties
Chem Biodivers. 2024 Feb 28:e202302115. doi: 10.1002/cbdv.202302115. Online ahead of print.ABSTRACTThe study focused on utilizing the anti-fungal and antioxidant properties of essential oils from Thymus daenensis Celak. subsp. daenensis to combat the growth of mycotoxin-producing Aspergillus species, including A. flavus, A. parasiticus, and A. niger, all common food and agricultural contaminants. The essential oil exhibited significant antifungal activity, accompanied by notable antioxidant properties. The essential oils from T. daenensis Celak. subsp. daenensis displayed significant inhibitory effects on all three Aspergi...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Seyed Fazel Mirahmadi Alireza Shayganfar Source Type: research
A Review on the Chemical Properties, Plant Sources, Anti-shock Effects, Pharmacokinetics, Toxicity, and Clinical Applications of Anisodamine
Chem Biodivers. 2024 Feb 28:e202301477. doi: 10.1002/cbdv.202301477. Online ahead of print.ABSTRACTAlkaloids are natural products that occur widely in many herbal plants. Anisodamine, widely present in the Solanaceae family, is an alkaloid extracted from the roots of the Anisodus tanguticus Maxim. It is an antagonist to M-choline receptors and exhibits diverse pharmacological effects, such as cholinolytic effect, calcium antagonist effect, anti-oxygenation effect. Anisodamine, a prominent constituent of the tropine alkaloid family, exhibits a range of pharmacological effects akin to those of atropine and scopolamine. owing...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Qiurui Xia Pingcuo Raoji Ce Yang Wei Xiong Xiaoyan Peng Jing Xia Wenxiang Wang Meirong Hai Source Type: research
Variability of Isoquinoline Alkaloid Profiles and Anticholinesterase Activities with Binding-mode Predictions of Glaucium flavum Population
In this study, phytochemical and biological activity studies supported by docking were carried out on a species of the genus Glaucium, a repository of isoquinoline alkaloids. The GC-MS (Gas Chromatography-Mass Spectrometry) method is used to characterize the isoquinoline alkaloids of Glaucium flavum Crantz. (Papaveraceae). G. flavum was collected from seven different regions of Türkiye (Antalya, Urla-Izmir, Mordogan-Izmir, Mugla, Assos-Canakkale, Karabiga-Canakkale, Giresun) and totally 17 compounds were detected by GC-MS. Glaucine was found to be the major constituent in the sample collected from Mugla, whereas isocorydi...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Buket Bozkurt Duygu Ulkar Necati Nurlu Gunes Coban Zinar Pinar Gumus Nehir Unver-Somer Source Type: research
Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An review
Chem Biodivers. 2024 Feb 28:e202301962. doi: 10.1002/cbdv.202301962. Online ahead of print.ABSTRACTStingless bees belong to the Meliponini tribe and are widely distributed in the tropics and subtropics, where they perform important ecological services. Among the best distributed groups of stingless bees is the genus Scaptotrigona, which includes 22 species distributed throughout the neotropical region, including the area from Mexico to Argentina. Bees of this genus are responsible for the production of products such as honey, propolis, geopropolis and fermented pollen ("saburá"). This review aimed to provide an overview o...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Zildene de Sousa Silveira Nair Silva Mac êdo Silva Macêdo D ébora de Menezes Dantas Samuel Vieira Brito Helcio Silva Silva Dos Santos Renata Val éria Regis de Sousa Gomese Henrique Douglas Assis Melo Coutinho Francisco Assis Assis Bezerra da Cunha M Source Type: research
Discovery of a pimaradiene that decreases viability of MDA-MB-468 cells through inhibition of EGFR signaling pathway
Chem Biodivers. 2024 Feb 28:e202400288. doi: 10.1002/cbdv.202400288. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is characterized by strong invasiveness, high relapse rates and poor overall survival and occurs in approximately 15-20% of all breast cancer cases. Natural compounds are a promising option for managing breast cancer. ent-8(14),15-Pimaradiene-2β,19-diol (JXE-23), is a pimaradiene isolated from the fern Aleuritopteris albofusca. However, the effects and molecular mechanisms of JXE-23 on cancer cells are still unknown. Thus, this study was designed to determine the potential of JXE-23 for i...
Source: Chemistry and Biodiversity - February 28, 2024 Category: Biochemistry Authors: Nina Wang Li Qin Zi Liu Jianguo Cao Jiayi Huang Liang Ma Guozheng Huang Source Type: research
