Structure and Synthesis of Vindolicine and Derivatives
This article describes the reaction of vindoline with formaldehyde and trimethyl orthoformate to prepare vindolicine, tris-vindolicinyl methane and higher molecular weight homologues. The synthesis of 10-formyl vindoline as an intermediate allowed further exploration of its chemistry, in particular the reaction with acetone which yielded a symmetrical dimer, which was further reacted with vindoline to give molecules containing three and four vindoline units. These molecules were characterized by NMR and for some of them (vindolicine, 10-formyl vindoline, 10-(1'-(but-1'-en-3'-one))-vindoline) by X-ray crystallography. Depen...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: None Asia Yousuf Sammer Laure Vendier Georges Massiot Source Type: research
Lipidomic Profiling and Pharmacological Activities of Ficus drupacea Oil: Comparative Study Between Conventional vs. Green Solvent
Chem Biodivers. 2024 Feb 26:e202302124. doi: 10.1002/cbdv.202302124. Online ahead of print.ABSTRACTFicus drupacea is a medicinal tree found in temperate regions. Various parts of this plant had been used traditionally for the treatment of various ailments such as root powder applied externally for skin infections. Analysis was carried out on the bioactive lipids extracted from Ficus drupacea fruit using both petroleum-based solvent (Hexane) and an environmentally friendly solvent Dimethyl carbonate (DMC). The results showed that DMC extraction yielded a high oil content in Ficus drupacea fruit (6.51%). When examining the f...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Palak Kansal Abha Shukla Rishi Kumar Shukla Source Type: research
Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum
Chem Biodivers. 2024 Feb 27:e202400002. doi: 10.1002/cbdv.202400002. Online ahead of print.ABSTRACTSeven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Yin-Yin Wang Yin-Bo Pan Ze-Yi Wan Jun-Jiang Li Jie Bao Jun-Sheng Zhang Hua Zhang Source Type: research
Chemical Profiling and Enzyme Inhibitory Activities of Essential Oil Isolated from Pistacia Khinjuk Leaves: Insights On GC-MS Analysis and Skin Aging-Relevant Enzymes
This study aimed to investigate the GC-MS chemical composition of essential oil isolated from Pistaciakhinjuk leaves and its inhibitory properties against aging-relevant enzymes such a collagenase and elastase. The isolated oil showed predominance of β-cadinene (15.34%), γ-amorphene (8.50%), α-cadinol (8.14%), τ-cadinol (7.57%), (E)-β-caryophyllene (5.77%), α-pinene (4.70%), phytol (4.57%), α-muurolene (3.30%), (+)-epi-bicyclosesquiphellandrene (3.21%), and cubenene (3.16%). Further, it showed remarkable inhibitory activities against collagenase and elastase with IC50 values of 15.61±0.69 and 41.12±2.09 μg/mL, re...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Hossam Kamli Abdallah A S Ali Yasmin Salem Ahmad Shaikh Heba A S El-Nashar Source Type: research
Isolation and Bioactivity Evaluation of Sesquiterpenes from an Alcyonarian of the Genus Lemnalia from the Saudi Arabian Red Sea
Chem Biodivers. 2024 Feb 27:e202400235. doi: 10.1002/cbdv.202400235. Online ahead of print.ABSTRACTOver the last decades, soft corals have been proven a rich source of biologically active compounds, featuring a wide range of chemical structures. Herein, we investigated the chemistry of an alcyonarian of the genus Lemnalia (Neptheidae), specimens of which were collected from the coral reefs near Al Lith, on the south-west coast of Saudi Arabia. A series of chromatographic separations led to the isolation of 31 sesquiterpenes, featuring mainly the nardosinane and neolemnane carbon skeletons, among which three (13, 14 and 28)...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Efstathia Ioannou Aikaterini Koutsaviti Marie Kvasnicov á Gabriel Gonzalez Tereza Štenclová Susana Agusti Carlos M Duarte Lucie Rarov á Miroslav Strnad Vassilios Roussis Source Type: research
Structure and Synthesis of Vindolicine and Derivatives
This article describes the reaction of vindoline with formaldehyde and trimethyl orthoformate to prepare vindolicine, tris-vindolicinyl methane and higher molecular weight homologues. The synthesis of 10-formyl vindoline as an intermediate allowed further exploration of its chemistry, in particular the reaction with acetone which yielded a symmetrical dimer, which was further reacted with vindoline to give molecules containing three and four vindoline units. These molecules were characterized by NMR and for some of them (vindolicine, 10-formyl vindoline, 10-(1'-(but-1'-en-3'-one))-vindoline) by X-ray crystallography. Depen...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: None Asia Yousuf Sammer Laure Vendier Georges Massiot Source Type: research
Lipidomic Profiling and Pharmacological Activities of Ficus drupacea Oil: Comparative Study Between Conventional vs. Green Solvent
Chem Biodivers. 2024 Feb 26:e202302124. doi: 10.1002/cbdv.202302124. Online ahead of print.ABSTRACTFicus drupacea is a medicinal tree found in temperate regions. Various parts of this plant had been used traditionally for the treatment of various ailments such as root powder applied externally for skin infections. Analysis was carried out on the bioactive lipids extracted from Ficus drupacea fruit using both petroleum-based solvent (Hexane) and an environmentally friendly solvent Dimethyl carbonate (DMC). The results showed that DMC extraction yielded a high oil content in Ficus drupacea fruit (6.51%). When examining the f...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Palak Kansal Abha Shukla Rishi Kumar Shukla Source Type: research
Anti-inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN-EF006 of Vaccinium bracteatum
Chem Biodivers. 2024 Feb 27:e202400002. doi: 10.1002/cbdv.202400002. Online ahead of print.ABSTRACTSeven new polyketides including three chromone derivatives (1-3) and four linear ones incorporating a tetrahydrofuran ring (4-7), along with three known compounds (8-10), were obtained from the fermentation of an endophytic fungus (Chaetomium sp. UJN-EF006) isolated from the leaves of Vaccinium bracteatum. The structures of these fungal metabolites have been elucidated by spectroscopic means including MS, NMR and electronic circular dichroism. A preliminary anti-inflammatory screening with the lipopolysaccharide (LPS) induced...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Yin-Yin Wang Yin-Bo Pan Ze-Yi Wan Jun-Jiang Li Jie Bao Jun-Sheng Zhang Hua Zhang Source Type: research
Chemical Profiling and Enzyme Inhibitory Activities of Essential Oil Isolated from Pistacia Khinjuk Leaves: Insights On GC-MS Analysis and Skin Aging-Relevant Enzymes
This study aimed to investigate the GC-MS chemical composition of essential oil isolated from Pistaciakhinjuk leaves and its inhibitory properties against aging-relevant enzymes such a collagenase and elastase. The isolated oil showed predominance of β-cadinene (15.34%), γ-amorphene (8.50%), α-cadinol (8.14%), τ-cadinol (7.57%), (E)-β-caryophyllene (5.77%), α-pinene (4.70%), phytol (4.57%), α-muurolene (3.30%), (+)-epi-bicyclosesquiphellandrene (3.21%), and cubenene (3.16%). Further, it showed remarkable inhibitory activities against collagenase and elastase with IC50 values of 15.61±0.69 and 41.12±2.09 μg/mL, re...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Hossam Kamli Abdallah A S Ali Yasmin Salem Ahmad Shaikh Heba A S El-Nashar Source Type: research
Isolation and Bioactivity Evaluation of Sesquiterpenes from an Alcyonarian of the Genus Lemnalia from the Saudi Arabian Red Sea
Chem Biodivers. 2024 Feb 27:e202400235. doi: 10.1002/cbdv.202400235. Online ahead of print.ABSTRACTOver the last decades, soft corals have been proven a rich source of biologically active compounds, featuring a wide range of chemical structures. Herein, we investigated the chemistry of an alcyonarian of the genus Lemnalia (Neptheidae), specimens of which were collected from the coral reefs near Al Lith, on the south-west coast of Saudi Arabia. A series of chromatographic separations led to the isolation of 31 sesquiterpenes, featuring mainly the nardosinane and neolemnane carbon skeletons, among which three (13, 14 and 28)...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Efstathia Ioannou Aikaterini Koutsaviti Marie Kvasnicov á Gabriel Gonzalez Tereza Štenclová Susana Agusti Carlos M Duarte Lucie Rarov á Miroslav Strnad Vassilios Roussis Source Type: research
Preventing Cancer by Inhibiting Ornithine Decarboxylase: A Comparative Perspective on Synthetic vs. Natural Drugs
Chem Biodivers. 2024 Feb 25:e202302067. doi: 10.1002/cbdv.202302067. Online ahead of print.ABSTRACTThis perspective explores synthetic and natural inhibitors, their inhibition patterns, and the efficacy of recently employed natural compounds as inhibitors for Ornithine decarboxylase enzyme which targets the MYC oncogene, and links polyamine metabolism to oncogenesis in normal and cancer cells. ODC activation and heightened polyamine activity are associated with tumor development in numerous cancers and fluctuations in ODC protein levels exert a profound influence on cellular activity for inhibition or suppressing tumor cel...
Source: Chemistry and Biodiversity - February 26, 2024 Category: Biochemistry Authors: Preeti Nanda Sahu Anik Sen Source Type: research
Evaluation of the phenolic content and the nutraceutical potential of ancestor and cultivated artichoke
Chem Biodivers. 2024 Feb 26:e202400203. doi: 10.1002/cbdv.202400203. Online ahead of print.ABSTRACTWild cardoon (Cynara cardunculus var. sylvestris) is the ancestor of many cultivated forms, including globe artichoke (C. cardunculus var. scolymus). Four organs (receptacles, bracts, leaves and stems) of wild and cultivated artichokes (organic and conventional) were assessed considering their individual phenolic constituents (HPLC-DAD), total phenol-flavonoid content, and pharmaceutical potentials (antibacterial and antioxidant). All three sources of artichokes had the highest concentration of 1,3-dicaffeoylquinic acid (cyna...
Source: Chemistry and Biodiversity - February 26, 2024 Category: Biochemistry Authors: Arzu Ucar Turker Sevinc Basay Ayca Cimen Yavuz Baba Arzu Birinci Yildirim Source Type: research
Synthesis, Antimicrobial Activities, and Molecular Modeling Studies of Agents for the Sortase A Enzyme
Chem Biodivers. 2024 Feb 26:e202301659. doi: 10.1002/cbdv.202301659. Online ahead of print.ABSTRACTSortase A (SrtA) is an attractive target for developing new anti-infective drugs that aim to interfere with essential virulence mechanisms, such as adhesion to host cells and biofilm formation. Herein, twenty hydroxy, nitro, bromo, fluoro, and methoxy substituted chalcone compounds T1-20 were synthesized, antimicrobial activities and molecular modeling strategies against the SrtA enzyme were investigated. The most active compounds were found to be T2, T4, and T19 against Streptococcus mutans (S. mutans) with the MIC values; 1...
Source: Chemistry and Biodiversity - February 26, 2024 Category: Biochemistry Authors: Gizem Tatar Yilmaz Nurettin Yayli Tamer T üzüner G özde Bozdal Merve Salmanli G ülin Renda B üşra Korkmaz Arif Bozdeveci Şengül Alpay Karaoğlu Source Type: research
Preventing Cancer by Inhibiting Ornithine Decarboxylase: A Comparative Perspective on Synthetic vs. Natural Drugs
Chem Biodivers. 2024 Feb 25:e202302067. doi: 10.1002/cbdv.202302067. Online ahead of print.ABSTRACTThis perspective explores synthetic and natural inhibitors, their inhibition patterns, and the efficacy of recently employed natural compounds as inhibitors for Ornithine decarboxylase enzyme which targets the MYC oncogene, and links polyamine metabolism to oncogenesis in normal and cancer cells. ODC activation and heightened polyamine activity are associated with tumor development in numerous cancers and fluctuations in ODC protein levels exert a profound influence on cellular activity for inhibition or suppressing tumor cel...
Source: Chemistry and Biodiversity - February 26, 2024 Category: Biochemistry Authors: Preeti Nanda Sahu Anik Sen Source Type: research
Therapeutic Potential of Cornus Genus: Navigating Phytochemistry, Pharmacology, Clinical Studies, and Advanced Delivery Approaches
Chem Biodivers. 2024 Feb 25:e202301888. doi: 10.1002/cbdv.202301888. Online ahead of print.ABSTRACTThe genus Cornus (Cornaceae) plants are widely distributed in Europe, southwest Asia, North America, and the mountains of Central America, South America, and East Africa. Cornus plants exhibit antimicrobial, antioxidative, antiproliferative, cytotoxic, antidiabetic, anti-inflammatory, neuroprotective and immunomodulatory activities. These plants are exploited to possess various phytoconstituents such as triterpenoids, iridoids, anthocyanins, tannins and flavonoids. Pharmacological research and clinical investigations on vario...
Source: Chemistry and Biodiversity - February 25, 2024 Category: Biochemistry Authors: Subhashini Badoni Deepshikha Rawat Arun Kumar Mahato Nitish Singh Jangwan Ghulam Md Ashraf Athanasios Alexiou Haythum O Tayeb Badrah S Alghamdi Marios Papadakis Mamta F Singh Source Type: research
