Plant-Derived Coumarins: A Narrative Review Of Their Structural And Biomedical Diversity
In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.PMID:38587035 | DOI:10.1002/cbdv.202400344 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 8, 2024 Category: Biochemistry Authors: Areej Hazem Younes Yasser Fakri Mustafa Source Type: research
Advances and Strategies towards Synthesis of Aspidosperma Indole Alkaloids Goniomitine
Chem Biodivers. 2024 Apr 8:e202400416. doi: 10.1002/cbdv.202400416. Online ahead of print.ABSTRACTGoniomitine is of the aspidosperma alkaloid family, with an angularly fused tetracyclic skeleton housing an all-carbon quaternary carbon chiral center alongside an aminal functional group. This natural product has garnered attention as a synthetic target due to its intriguing molecular architecture and anti-proliferative activity in recent years. Following the first synthesis of (-)-goniomitine by Takano in 1991, synthetic chemists have developed various methods. This review provides an overview of the methodologies used in th...
Source: Chemistry and Biodiversity - April 8, 2024 Category: Biochemistry Authors: Cong-Bin Ji Source Type: research
Modified Citrus Pectin (MCP) Confers a Renoprotective Effect on Early-Stage Nephropathy in Type-2 Diabetic Mice
Chem Biodivers. 2024 Apr 8:e202400104. doi: 10.1002/cbdv.202400104. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a significant global health concern with a high morbidity rate. Accumulating evidence reveals that Galectin-3 (Gal-3), a β-galactoside-binding lectin, is a biomarker in kidney diseases. Our study aimed to assess the advantageous impacts of modified citrus pectin (MCP) as an alternative therapeutic strategy for the initial and ongoing progression of DN in mice with type 2 diabetes mellitus (T2DM). The animal model has been split into four groups: control group, T2DM group (mice received intraperito...
Source: Chemistry and Biodiversity - April 8, 2024 Category: Biochemistry Authors: Hager M Mahmoud Abdel-Razik H Abdel-Razik Mahmoud A Elrehany Eman M Othman Amany A Bekhit Source Type: research
N α-aroyl-N-aryl-phenylalanine amides: a promising class of antimycobacterial agents targeting the RNA polymerase
Chem Biodivers. 2024 Apr 8:e202400267. doi: 10.1002/cbdv.202400267. Online ahead of print.ABSTRACTTuberculosis (TB), mainly caused by Mycobacterium tuberculosis, remains the leading cause of death from a bacterium in the world. The global prevalence of clinically relevant infections with opportunistically pathogenic non-tuberculous mycobacteria (NTM) have also been on the rise. Pharmacological treatment of both TB and NTM infections usually requires prolonged regimens of drug combinations, and is often challenging because of developed or inherent resistance to common antibiotic drugs. Medicinal chemistry efforts are thus n...
Source: Chemistry and Biodiversity - April 8, 2024 Category: Biochemistry Authors: R üdiger W Seidel Richard Goddard Markus Lang Adrian Richter Source Type: research
Phytochemical Profile, Antioxidant, Enzyme Inhibition, Acute Toxicity, In Silico Molecular Docking and Dynamic Analysis of Apis mellifera Propolis as Antidiabetic Supplement
This study aims to identification of phytochemical profile of Apis mellifera propolis and explore potential of its anti-diabetic activity through inhibition on α-amylase (α-AE), α-glucosidase(α-GE) and finally identified the novel antidiabetic compounds from propolis. Apis mellifera propolis extract (AMPE) exhibited elevated polyphenol 33.26 ± 0.17 (mg GAE/g) and flavonoid (15.45 ± 0.13 mg RE/g), while its also indicated moderate strong antioxidant activity (EC50 793.09 ±1.94 µg/ml). This study found that AMPE displayed promising α-AE and α-GE inhibition through in vitro study. Based on LC-MS/MS screening, 18 uni...
Source: Chemistry and Biodiversity - April 7, 2024 Category: Biochemistry Authors: Putri Hawa Syaifie Delfritama Ibadillah Muhammad Miftah Jauhar Rikania Reninta Sri Ningsih Donny Ramadhan Adzani Gaisani Arda Dhecella Winy Cintya Ningrum Nofa Mardia Ningsih Kaswati Nurul Taufiqu Rochman Etik Mardliyati Source Type: research
Phyto-fabrication of Moringa oleifera peel-sourced silver nanoparticles: A promising approach for combating hepatic cancer by targeting proinflammatory cytokines and mitigating cytokine storms
This study focuses on the eco-friendly synthesis of silver nanoparticles infused with M. oleifera peel extract biomolecules and their impact on regulating proinflammatory cytokines, as well as their potential anticancer effects against Wistar rats. The freshly synthesized nanoformulation underwent comprehensive characterization, followed by antihepatic cancer evaluation using a diethyl nitrosamine-induced model (at a dose of 200 mg kg-1 BW). The study demonstrates a significant reduction in proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, interleukin-1β, and nuclear factor kappa beta (NF-kB). Fur...
Source: Chemistry and Biodiversity - April 7, 2024 Category: Biochemistry Authors: Shahnawaz Sameem Vivek Dwivedi Vikas Kumar Ashish R Dwivedi Prateek Pathak Bhupendra Singh Mashooq Ahmad Bhat Amita Verma Source Type: research
Bio-guided Isolation of Alpha-glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella montagnei
Chem Biodivers. 2024 Apr 5:e202400438. doi: 10.1002/cbdv.202400438. Online ahead of print.ABSTRACTA bio-guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha-glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost-7-en-3β-ol (3), ethyl orsellinate (4), D-montagnetol (5), and D-erythrin (6). Their chemical structures were identified by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, and comparisons with those reported in the literatu...
Source: Chemistry and Biodiversity - April 6, 2024 Category: Biochemistry Authors: Thuc Huy Duong Huong Thuy Le Y Thien Vu Gia-Huy Duong Thi-Kim-Dung Le Minh-Khai Dang Duc-Dung Pham Nguyen-Kim-Tuyen Pham Jirapast Sichaem Ngoc-Hong Nguyen Source Type: research
Carane-3,4-diol Derivatives as Potential Water-Based Herbicides
Chem Biodivers. 2024 Apr 6:e202301867. doi: 10.1002/cbdv.202301867. Online ahead of print.ABSTRACTTwelve novel carane-3,4-diol derivatives were designed, synthesized, and evaluated for their herbicidal activities against Lolium multiflorum Lam. and Brassica campestris for the first time. The relationships between the chemical structural factors, including types, the number or the carbon chain length of functional groups, associated with the lipophilicity and the herbicidal activity of the tested compounds were also discussed. The results showed that most of newly synthesized compounds had a dose-dependent, herbicidal activ...
Source: Chemistry and Biodiversity - April 6, 2024 Category: Biochemistry Authors: Yanqun Huang Maomao Zhu Hongyun Lan Daozhan Huang Mengna Lan Yanning Huang Source Type: research
Bio-guided Isolation of Alpha-glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella montagnei
Chem Biodivers. 2024 Apr 5:e202400438. doi: 10.1002/cbdv.202400438. Online ahead of print.ABSTRACTA bio-guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha-glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost-7-en-3β-ol (3), ethyl orsellinate (4), D-montagnetol (5), and D-erythrin (6). Their chemical structures were identified by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, and comparisons with those reported in the literatu...
Source: Chemistry and Biodiversity - April 6, 2024 Category: Biochemistry Authors: Thuc Huy Duong Huong Thuy Le Y Thien Vu Gia-Huy Duong Thi-Kim-Dung Le Minh-Khai Dang Duc-Dung Pham Nguyen-Kim-Tuyen Pham Jirapast Sichaem Ngoc-Hong Nguyen Source Type: research
Carane-3,4-diol Derivatives as Potential Water-Based Herbicides
Chem Biodivers. 2024 Apr 6:e202301867. doi: 10.1002/cbdv.202301867. Online ahead of print.ABSTRACTTwelve novel carane-3,4-diol derivatives were designed, synthesized, and evaluated for their herbicidal activities against Lolium multiflorum Lam. and Brassica campestris for the first time. The relationships between the chemical structural factors, including types, the number or the carbon chain length of functional groups, associated with the lipophilicity and the herbicidal activity of the tested compounds were also discussed. The results showed that most of newly synthesized compounds had a dose-dependent, herbicidal activ...
Source: Chemistry and Biodiversity - April 6, 2024 Category: Biochemistry Authors: Yanqun Huang Maomao Zhu Hongyun Lan Daozhan Huang Mengna Lan Yanning Huang Source Type: research
An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides
This study examines the potential of electrochemical sensors for the accurate evaluation of various effects of pesticides. Emphasizing the use of Graphene (GR), Graphene Oxide (GO), Reduced Graphene Oxide (rGO), and Graphdiyne composites, the study highlights their enhanced performance in pesticide sensing by stating the account of many actual sensors that have been made for specific pesticides. Computational studies provide valuable insights into the adsorption kinetics, binding energies, and electronic properties of pesticide-graphene complexes, guiding the design and optimization of graphene-based sensors with improved ...
Source: Chemistry and Biodiversity - April 5, 2024 Category: Biochemistry Authors: Anirudh Pratap Singh Raman Gauri Thakur Garima Pandey Kamlesh Kumari Prashant Singh Source Type: research
A Review on Ethnobotany, Phytochemistry and Pharmacological activities of Euphorbia antiquorum L
Chem Biodivers. 2024 Apr 5:e202400331. doi: 10.1002/cbdv.202400331. Online ahead of print.ABSTRACTEuphorbia antiquorum L. is a small plant in the Euphorbiaceae family that is found primarily in tropical and subtropical Asia. It has a long tradition of being utilized in Chinese, Ayurvedic, and other traditional systems for a variety of ailments. To date, More than 116 bioactive constituents were isolated from Euphorbia antiquorum, with diterpenoids being the most abundant. Extracts and isolated chemicals from various portions of the plant have demonstrated significant pharmacological activities such as anti-inflammatory, an...
Source: Chemistry and Biodiversity - April 5, 2024 Category: Biochemistry Authors: Lunasmrita Saikia Jyotirmoy Bhattacharyya Saikat Sen Partha Pratim Dutta Source Type: research
Identifying anti-NSCLC bioactive compounds in Scutellaria via 2D NMR-based metabolomic analysis of pharmacologically classified crude extracts
This study demonstrated 2D NMR-based metabolomic analysis of pharmacologically classified crude extracts to be an efficient approach to the identification of active components of herbal medicine.PMID:38581076 | DOI:10.1002/cbdv.202400258 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - April 5, 2024 Category: Biochemistry Authors: Jialuo Chen Yanping Li Xiu Gu Tianren Wu Huan Du Caihong Bai Jiahui Yang Kaifeng Hu Source Type: research
An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides
This study examines the potential of electrochemical sensors for the accurate evaluation of various effects of pesticides. Emphasizing the use of Graphene (GR), Graphene Oxide (GO), Reduced Graphene Oxide (rGO), and Graphdiyne composites, the study highlights their enhanced performance in pesticide sensing by stating the account of many actual sensors that have been made for specific pesticides. Computational studies provide valuable insights into the adsorption kinetics, binding energies, and electronic properties of pesticide-graphene complexes, guiding the design and optimization of graphene-based sensors with improved ...
Source: Chemistry and Biodiversity - April 5, 2024 Category: Biochemistry Authors: Anirudh Pratap Singh Raman Gauri Thakur Garima Pandey Kamlesh Kumari Prashant Singh Source Type: research
A Review on Ethnobotany, Phytochemistry and Pharmacological activities of Euphorbia antiquorum L
Chem Biodivers. 2024 Apr 5:e202400331. doi: 10.1002/cbdv.202400331. Online ahead of print.ABSTRACTEuphorbia antiquorum L. is a small plant in the Euphorbiaceae family that is found primarily in tropical and subtropical Asia. It has a long tradition of being utilized in Chinese, Ayurvedic, and other traditional systems for a variety of ailments. To date, More than 116 bioactive constituents were isolated from Euphorbia antiquorum, with diterpenoids being the most abundant. Extracts and isolated chemicals from various portions of the plant have demonstrated significant pharmacological activities such as anti-inflammatory, an...
Source: Chemistry and Biodiversity - April 5, 2024 Category: Biochemistry Authors: Lunasmrita Saikia Jyotirmoy Bhattacharyya Saikat Sen Partha Pratim Dutta Source Type: research
