Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
Synthesis and in vitro anti-inflammatory activity of novel dendrobine amide/sulfonamide derivatives
Chem Biodivers. 2024 Mar 21:e202400030. doi: 10.1002/cbdv.202400030. Online ahead of print.ABSTRACTA traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities in vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96 μM. Western bl...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: ZiWei Jiao HanFei Liu KaiQin Lin GuangTong Xie HuaYong Lou WeiDong Pan MaoSheng Zhang Source Type: research
Chemical Composition, Repellent, and Phytotoxic Potentials of the Fractionated Resin Essential Oil from Araucaria heterophylla Growing in Tunisia
Chem Biodivers. 2024 Mar 21:e202400185. doi: 10.1002/cbdv.202400185. Online ahead of print.ABSTRACTThe resin essential oil (REO) of Araucaria heterophylla trunk bark was investigated for its chemical composition. Then, it was evaluated for its insecticidal and allelopathic activities. The REO was obtained by hydrodistillation for 9 h (yield of 4.2% w/w). Moreover, fractional hydrodistillation was carried out at 3-hour intervals, resulting in 3 fractions (R1-R3). GC/MS analysis of the obtained samples allowed the identification of 25 compounds, representing between 91.2 and 96.3% of their total constituents, which consisted...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Oumayma Ben Romdhane Wiem Baccari Ilyes Saidi Guido Flamini Roberta Ascrizzi Ikbal Chaieb Abdel Halim Harrath Hichem Ben Jannet Source Type: research
Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents
This study can act as a beacon for further research in the application of furan-pyrazole and furan-2,4-thiazolidinediones as lead moieties for anti-neuroinflammatory and related diseases.PMID:38513005 | DOI:10.1002/cbdv.202301260 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Sowjanya Mudimela Vijayasree V Giridharan Saravanan Janardhan Source Type: research
Pulvinic Acid Derivative Pigments in Lanmaoa asiatica and L. macrocarpa
Chem Biodivers. 2024 Mar 21:e202301996. doi: 10.1002/cbdv.202301996. Online ahead of print.ABSTRACTLanmaoa asiatica G.Wu & Zhu L.Yang and L. macrocarpa N.K.Zeng,H.Chai&S. Jiang are two important gourmet bolete in China, and locally named "Jian Shou Qing" meaning their fruiting bodies turn blue after bruising. The genus represents a distinct lineage in Boletaceae. The pigment(s) associated with the discoloration in Lanmaoa has not been identified. The aim of this study was to determine the pigment(s) underpinning the bluing reaction of L. asiatica and L. macrocarpa when bruised. Potential compounds were isolated by ...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Yixiao Wang Yunjiao L üli Xuan Li Zhuliang Yang Hong Luo Source Type: research
Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
Synthesis and in vitro anti-inflammatory activity of novel dendrobine amide/sulfonamide derivatives
Chem Biodivers. 2024 Mar 21:e202400030. doi: 10.1002/cbdv.202400030. Online ahead of print.ABSTRACTA traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities in vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96 μM. Western bl...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: ZiWei Jiao HanFei Liu KaiQin Lin GuangTong Xie HuaYong Lou WeiDong Pan MaoSheng Zhang Source Type: research
Chemical Composition, Repellent, and Phytotoxic Potentials of the Fractionated Resin Essential Oil from Araucaria heterophylla Growing in Tunisia
Chem Biodivers. 2024 Mar 21:e202400185. doi: 10.1002/cbdv.202400185. Online ahead of print.ABSTRACTThe resin essential oil (REO) of Araucaria heterophylla trunk bark was investigated for its chemical composition. Then, it was evaluated for its insecticidal and allelopathic activities. The REO was obtained by hydrodistillation for 9 h (yield of 4.2% w/w). Moreover, fractional hydrodistillation was carried out at 3-hour intervals, resulting in 3 fractions (R1-R3). GC/MS analysis of the obtained samples allowed the identification of 25 compounds, representing between 91.2 and 96.3% of their total constituents, which consisted...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Oumayma Ben Romdhane Wiem Baccari Ilyes Saidi Guido Flamini Roberta Ascrizzi Ikbal Chaieb Abdel Halim Harrath Hichem Ben Jannet Source Type: research
Molecular Docking, Synthesis, and Characterization of Furanyl-pyrazolyl acetamide and 2,4-thiazolidinyl-furan-3-carboxamide Derivatives as Neuroinflammatory Protective Agents
This study can act as a beacon for further research in the application of furan-pyrazole and furan-2,4-thiazolidinediones as lead moieties for anti-neuroinflammatory and related diseases.PMID:38513005 | DOI:10.1002/cbdv.202301260 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Sowjanya Mudimela Vijayasree V Giridharan Saravanan Janardhan Source Type: research
Pulvinic Acid Derivative Pigments in Lanmaoa asiatica and L. macrocarpa
Chem Biodivers. 2024 Mar 21:e202301996. doi: 10.1002/cbdv.202301996. Online ahead of print.ABSTRACTLanmaoa asiatica G.Wu & Zhu L.Yang and L. macrocarpa N.K.Zeng,H.Chai&S. Jiang are two important gourmet bolete in China, and locally named "Jian Shou Qing" meaning their fruiting bodies turn blue after bruising. The genus represents a distinct lineage in Boletaceae. The pigment(s) associated with the discoloration in Lanmaoa has not been identified. The aim of this study was to determine the pigment(s) underpinning the bluing reaction of L. asiatica and L. macrocarpa when bruised. Potential compounds were isolated by ...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Yixiao Wang Yunjiao L üli Xuan Li Zhuliang Yang Hong Luo Source Type: research
Emodin Blocks mPTP Opening and Improves LPS-induced HMEC-1Cell Injury by Upregulation of ATP5A1
CONCLUSION: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.PMID:38511277 | DOI:10.1002/cbdv.202301916 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: Tietao Di Limin He Qing Shi Lu Chen Lei Zhu Sisi Zhao Chunling Zhang Source Type: research
Synthesis and in vitro anti-inflammatory activity of novel dendrobine amide/sulfonamide derivatives
Chem Biodivers. 2024 Mar 21:e202400030. doi: 10.1002/cbdv.202400030. Online ahead of print.ABSTRACTA traditional Chinese medicine ingredient, dendrobine, has been demonstrated to have anti-inflammatory properties. However, due to its poor anti-inflammatory properties, its clinical use is limited. Consequently, we have designed and synthesized 32 new amide/sulfonamide dendrobine derivatives and screened their anti-inflammatory activities in vitro. Experiments showed that nitric oxide (NO) generation in lipopolysaccharide (LPS)-induced RAW264.7 cells was strongly reduced by derivative 14, with an IC50 of 2.96 μM. Western bl...
Source: Chemistry and Biodiversity - March 21, 2024 Category: Biochemistry Authors: ZiWei Jiao HanFei Liu KaiQin Lin GuangTong Xie HuaYong Lou WeiDong Pan MaoSheng Zhang Source Type: research
Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease
CONCLUSION: This study preliminarily demonstrated that puerarin and genistein in Pueraria lobata may increase hepcidin production to alleviate alcohol-induced iron overload by inhibiting the MAPK/ERK signaling pathway.PMID:38504590 | DOI:10.1002/cbdv.202400005 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 20, 2024 Category: Biochemistry Authors: Xue Li Le Liu Mei-Xuan Wan Li-Min Gong Juan Su Li Xu Source Type: research
Pharmacological Activities of Plant-Derived Fraxin with Molecular Mechanisms: A Comprehensive Review
This study focuses to investigate the pharmacological activities, botanical sources, and biopharmaceutical profile of the phytochemical fraxin based on different preclinical and non-clinical studies to show the scientific evidence and to evaluate the underlying molecular mechanisms of the therapeutic effects against various ailments. For this, data was searched and collected (as of February 15, 2024) in a variety of credible electronic databases, including PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web of Science, and Google Scholar. The findings demonstrated favorable outcomes in relation to a ran...
Source: Chemistry and Biodiversity - March 20, 2024 Category: Biochemistry Authors: Jannatul Ferdous Muhammad Shimul Bhuia Raihan Chowdhury Asraful Islam Rakib Mst Asma Aktar Muhammad Sakib Al Hasan Henrique Coutinho Muhammad Torequl Islam Source Type: research
Ameliorative Effect of Morinda officinalis oligosaccharides on LPS-induced Acute Lung Injury
Chem Biodivers. 2024 Mar 20:e202400506. doi: 10.1002/cbdv.202400506. Online ahead of print.ABSTRACTAcute lung injury (ALI) is a disease characterized by extensive lung damage and rampant inflammation, with a high mortality rate and no effective treatments available. Morinda officinalis oligosaccharide (MOOs), derived from the root of the traditional Chinese medicinal herb Morinda officinalis, known for its immune-boosting properties, presents a novel therapeutic possibility. To date, the impact of MOOs on ALI has not been explored. We discovered that MOOs significantly mitigated the pathological damage and decreased the ex...
Source: Chemistry and Biodiversity - March 20, 2024 Category: Biochemistry Authors: Cheng Wang Cheng Qing Yanrong Wu Binbin Liu Zhenguo Zeng Source Type: research
