Design, Synthesis and In vitro Antitubercular Effect of New Chalcone Derivatives Coupled with 1,2,3-Triazoles: A Computational Docking Techniques
Chem Biodivers. 2024 Mar 8:e202400389. doi: 10.1002/cbdv.202400389. Online ahead of print.ABSTRACTA very interesting foundation for this study is the creation of new methods for modifying compounds with a 1,2,3-triazole and chalcones, as these compounds are significant in organic synthesis as bioactive organic compounds. To contribute to the development of an efficient method for the conversion of antimicrobial and anti-TB drugs, a novel series of cyclohepta pyridinone fused 1,2,3-triazolyl chalcones were designed and synthesized. All the newly prepared scaffolds were characterized by IR, NMR (1H & 13C) and mass spectr...
Source: Chemistry and Biodiversity - March 8, 2024 Category: Biochemistry Authors: Kumaraswamy Sadineni Sravanthi Reddy Basireddy Tejeswara Rao Allaka Satyanarayana Yatam Srinu Bhoomandla Venkatanaryana Muvvala Sharath Babu Haridasyam Source Type: research
Stable Isotope Tracer Technique and Network Pharmacology to Reveal Antidepressant Targets and Active Components of Xiaoyao San
Chem Biodivers. 2024 Mar 7:e202301736. doi: 10.1002/cbdv.202301736. Online ahead of print.ABSTRACTIn recent years, the research of mitochondrial dysfunction in depression has drawn the focus of researchers. Our research group previously found that Xiaoyao San (XYS) has improved the mitochondrial structure and the blocked tricarboxylic acid cycle (TCA cycle) in the hippocampal tissue of chronic unpredictable mild stress (CUMS) rats. However, the specific targets and active components of XYS remain unclear, and the potential to improve hippocampal mitochondrial TCA cycle disorder was also unexplored. In this research, a stra...
Source: Chemistry and Biodiversity - March 7, 2024 Category: Biochemistry Authors: Junsheng Tian Xianxian Wang Wenze Wu Yunhao Zhao Ting Ling-Hu Xuemei Qin Source Type: research
Potential Hepatprrotective Effect of Matricaria Pubescens on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats
This study aimed to identify the phytochemical compounds of Matricaria pubescens by LC-MS/MS and evaluate the potential protective effect of its supplementation in high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in adult rats through modulation of oxidative stress and histopathological changes. Twenty-four male rats were randomly divided into four groups. The first group served as control and received the standard diet. The second group (HFD) received a high-fat diet only (30 % of sheep fat). The third group's (control+MP) animals received a standard diet supplemented with 5 % M. pubescens (w/w). The ...
Source: Chemistry and Biodiversity - March 7, 2024 Category: Biochemistry Authors: Chenna Houssem Khelef Yahia Halimi Imen Yilmaz Mustafa Abdullah Çakir Oğuz Djouder Chaouki Tarhan Abbas Idoughi Khouloud Boumendjel Mahieddine Boumendjel Amel Messarah Mahfoud Source Type: research
Corrigendum: Phytochemical Analysis and Evaluation of Genotoxic, Antigenotoxic Effects in Bacterial Models, and Hypoglycemic Activity of Epilobium angustifolium L. with Bioguided Isolation of Active Compounds
Chem Biodivers. 2024 Mar 7:e202400174. doi: 10.1002/cbdv.202400174. Online ahead of print.NO ABSTRACTPMID:38451251 | DOI:10.1002/cbdv.202400174 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - March 7, 2024 Category: Biochemistry Source Type: research
Design, synthesis and antifungal activity of nootkatone derivatives containing acylhydrazone and oxime ester
Chem Biodivers. 2024 Mar 7:e202400355. doi: 10.1002/cbdv.202400355. Online ahead of print.ABSTRACTIn an attempt to search for new natural products-based antifungal agents, fifty-three nootkatone derivatives were designed, synthesized, and evaluated for their antifungal activity against Phytophthora parasitica var nicotianae, Fusarium oxysporum, Fusarium graminearum and Phomopsis sp. by the mycelium growth rate method. Nootkatone derivatives N17 exhibited good inhibitory activity against Phomopsis. sp. with EC50 values of 2.02 μM. The control effect of N17 against Phomopsis. sp. on kiwifruit showed that N17 exhibited a goo...
Source: Chemistry and Biodiversity - March 7, 2024 Category: Biochemistry Authors: Liang QiLong Gao FuTian Jian JunYou Yang Jue Lie-Jun Huang Hao Xiaojiang Source Type: research
Chemical Constituents from the Heartwood of Solanum Verbascifolium L.And Their Anti-Inflammatory Activities Combined Network Pharmacology
Chem Biodivers. 2024 Mar 7:e202302111. doi: 10.1002/cbdv.202302111. Online ahead of print.ABSTRACTPhytochemical studies on 95% ethanol extract of the heartwood of Solanum verbascifolium L. resulted in the isolation of one new amide derivative (1), and 21 known phenylpropanoids compounds. The structures were characterized by spectral analysis and high-resolution mass spectrometric analysis. The anti-inflammatory activity of amide compounds 1-4 and 6-9 by investigating their impact on the release of nitric oxide (NO) in MH-S cells. Our findings unveiled significant inhibitory effects on NO secretion. Compound 1 exhibited rob...
Source: Chemistry and Biodiversity - March 7, 2024 Category: Biochemistry Authors: Jin-Na Zhao Shu-Fei Yu Zhi-Hang Wu Lu Chen Rong Fu Ze Li Yan-Liang Qu Jian Huang Libo Wang Xian-Mei Piao Jin-Hui Wang Source Type: research
Four New Isocoumarins from the Mangrove Fungus Alternaria malorum with antimicrobial activities
Chem Biodivers. 2024 Mar 6:e202400327. doi: 10.1002/cbdv.202400327. Online ahead of print.ABSTRACTFour new isocoumarins, alternariethers A-C (1-3) and alternariester (4) were separated from the fermentation of the fungus Alternaria malorum FL39, purified from Myoporum bontioides. Their structures were ascertained using NMR and HR-ESI-MS spectroscopy. For compound 4, the absolute configuration was solved with the help of ECD calculation and the DP4+ method. Compared with the positive control triadimefon, compound 1 showed more potent antifungal effects on Colletotrichum musae . The antifungal effects of compounds 1, 2, and ...
Source: Chemistry and Biodiversity - March 6, 2024 Category: Biochemistry Authors: Wei Fan Yiwen Tao Canmin Jiang Qisen Huang Jiacong Li Weijia Ding Chunyuan Li Source Type: research
Discovery of 6-Acylamino/Sulfonamido Benzoxazolone with IL-6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis
Chem Biodivers. 2024 Mar 6:e202400031. doi: 10.1002/cbdv.202400031. Online ahead of print.ABSTRACTUlcerative colitis has been widely concerned for its persistent upward trend and sustained overproduction of pro-inflammatory cytokines such as IL-6 remains a crucial factor in UC development. Therefore, identification of new effective drugs to block inflammatory responses is an urgent and viable strategy for UC. In our research, twenty-three 6-acylamino/sulfonamido benzoxazolone derivatives were synthesized, characterized, and evaluated for anti-inflammatory activity against NO and IL-6 in LPS-induced RAW264.7 cells. The resu...
Source: Chemistry and Biodiversity - March 6, 2024 Category: Biochemistry Authors: Re Ge Jiaqi Song Zhen Cao Shurong Ban Li Tang Qingshan Li Source Type: research
Four New Isocoumarins from the Mangrove Fungus Alternaria malorum with antimicrobial activities
Chem Biodivers. 2024 Mar 6:e202400327. doi: 10.1002/cbdv.202400327. Online ahead of print.ABSTRACTFour new isocoumarins, alternariethers A-C (1-3) and alternariester (4) were separated from the fermentation of the fungus Alternaria malorum FL39, purified from Myoporum bontioides. Their structures were ascertained using NMR and HR-ESI-MS spectroscopy. For compound 4, the absolute configuration was solved with the help of ECD calculation and the DP4+ method. Compared with the positive control triadimefon, compound 1 showed more potent antifungal effects on Colletotrichum musae . The antifungal effects of compounds 1, 2, and ...
Source: Chemistry and Biodiversity - March 6, 2024 Category: Biochemistry Authors: Wei Fan Yiwen Tao Canmin Jiang Qisen Huang Jiacong Li Weijia Ding Chunyuan Li Source Type: research
Discovery of 6-Acylamino/Sulfonamido Benzoxazolone with IL-6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis
Chem Biodivers. 2024 Mar 6:e202400031. doi: 10.1002/cbdv.202400031. Online ahead of print.ABSTRACTUlcerative colitis has been widely concerned for its persistent upward trend and sustained overproduction of pro-inflammatory cytokines such as IL-6 remains a crucial factor in UC development. Therefore, identification of new effective drugs to block inflammatory responses is an urgent and viable strategy for UC. In our research, twenty-three 6-acylamino/sulfonamido benzoxazolone derivatives were synthesized, characterized, and evaluated for anti-inflammatory activity against NO and IL-6 in LPS-induced RAW264.7 cells. The resu...
Source: Chemistry and Biodiversity - March 6, 2024 Category: Biochemistry Authors: Re Ge Jiaqi Song Zhen Cao Shurong Ban Li Tang Qingshan Li Source Type: research
Synthesis, Structural Characterization, and Biological Activities of 1,3,4- thiadiazole Derivatives Containing sulfonylpiperazine structures
Chem Biodivers. 2024 Mar 5:e202400408. doi: 10.1002/cbdv.202400408. Online ahead of print.ABSTRACTTo develop novel bacterial biofilm inhibiting agents, a series of 1,3,4-thiadiazole derivatives containing sulfonylpiperazine structures were designed, synthesized, and characterized using 1H nuclear magnetic resonance (1H NMR), 13C nuclear magnetic resonance (13C NMR), and high-resolution mass spectrometry. Meanwhile, their biological activities were evaluated, and the ensuing structure-activity relationships were discussed. The bioassay results showed the substantial antimicrobial efficacy exhibited by most of the compounds....
Source: Chemistry and Biodiversity - March 5, 2024 Category: Biochemistry Authors: You-Hua Liu Fa-Li Wang Xiao-Li Ren Chang-Kun Li Lin-Hong Jin Xia Zhou Source Type: research
Synthesis, Structural Characterization, and Biological Activities of 1,3,4- thiadiazole Derivatives Containing sulfonylpiperazine structures
Chem Biodivers. 2024 Mar 5:e202400408. doi: 10.1002/cbdv.202400408. Online ahead of print.ABSTRACTTo develop novel bacterial biofilm inhibiting agents, a series of 1,3,4-thiadiazole derivatives containing sulfonylpiperazine structures were designed, synthesized, and characterized using 1H nuclear magnetic resonance (1H NMR), 13C nuclear magnetic resonance (13C NMR), and high-resolution mass spectrometry. Meanwhile, their biological activities were evaluated, and the ensuing structure-activity relationships were discussed. The bioassay results showed the substantial antimicrobial efficacy exhibited by most of the compounds....
Source: Chemistry and Biodiversity - March 5, 2024 Category: Biochemistry Authors: You-Hua Liu Fa-Li Wang Xiao-Li Ren Chang-Kun Li Lin-Hong Jin Xia Zhou Source Type: research
Bioactivities and action mechanisms of ellipticine derivatives reported prior to 2023
Chem Biodivers. 2024 Mar 3:e202400210. doi: 10.1002/cbdv.202400210. Online ahead of print.ABSTRACTCurrently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its derivatives as bioactive molecules over the last 60 years. Publications focused mainly on the total synthesis of alkaloids of this ...
Source: Chemistry and Biodiversity - March 4, 2024 Category: Biochemistry Authors: Wen Hou Xin-Liang Xu Le-Jun Huang Zhen Yu Zhang Zhi-Nuo Zhou Jin-Yang Wang Xi Ouyang Su-Ya Xin Zi-Yun Zhang Yi Xiong Hao Huang Jin-Xia Lan Source Type: research
Aloe juvenna Brandham & amp; S.Carter as α-Amylase Inhibitor and Hypoglycaemic Agent with Anti-inflammatory Properties for Diabetes Management
This study describes the antidiabetic potentials and phytoconstituents of the A. juvenna leaves methanolic extract (AJME). Twenty-six phytoconstituents of AJME were described using HPLC/MS-MS. Lupeol and vitexin were isolated using column chromatography. The antidiabetic activity of AJME was investigated using an in vivo high-fat diet/streptozotocin-induced diabetic rat model and in vitro α-glucosidase and α-amylase inhibitory activity assays. AJME demonstrated its α-amylase inhibitory activity (IC50 = 313±39.9 ppm) with no effect on α-glucosidase. In vivo, AJME dose-dependently improved hyperglycaemia in a high-fat d...
Source: Chemistry and Biodiversity - March 4, 2024 Category: Biochemistry Authors: Mona Raslan Iman A A Kassem Neveen S Ghaly May A El-Manawaty Farouk Rasmy Melek Marian Nabil Source Type: research
Bioactivities and action mechanisms of ellipticine derivatives reported prior to 2023
Chem Biodivers. 2024 Mar 3:e202400210. doi: 10.1002/cbdv.202400210. Online ahead of print.ABSTRACTCurrently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its derivatives as bioactive molecules over the last 60 years. Publications focused mainly on the total synthesis of alkaloids of this ...
Source: Chemistry and Biodiversity - March 4, 2024 Category: Biochemistry Authors: Wen Hou Xin-Liang Xu Le-Jun Huang Zhen Yu Zhang Zhi-Nuo Zhou Jin-Yang Wang Xi Ouyang Su-Ya Xin Zi-Yun Zhang Yi Xiong Hao Huang Jin-Xia Lan Source Type: research
