Taxodin A, a Cytotoxic C30 Terpenoid from Taxodium mucronatum with a Unique Skeleton
Chem Biodivers. 2024 Mar 28:e202400648. doi: 10.1002/cbdv.202400648. Online ahead of print.ABSTRACTTaxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC50 values of 15.35...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Yao Li Zhi-Ping Zhou Li-Ting Chen Source Type: research
A Review on traditional uses, phytochemistry, pharmacology and clinical application of Tinospora sinensis (Lour.) Merr
Chem Biodivers. 2024 Mar 28:e202302037. doi: 10.1002/cbdv.202302037. Online ahead of print.ABSTRACTTinospora sinensis (T. sinensis), whose Tibetan name is "Lezhe", as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti-inflammatory, analgesic, immunosuppressive, anti-aging, anti-radiation, anti-...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Yan Liang Shao-Bo Guo Chang Xu Ying-Ying Su Cheng-Yuan Su Wei Zhang Bin Liu Source Type: research
Production of Aromatic Hydrocarbons from Co-hydropyrolysis of Biomass Components and HDPE with Application of Modified HZSM-5 Catalyst
Chem Biodivers. 2024 Mar 28:e202400150. doi: 10.1002/cbdv.202400150. Online ahead of print.ABSTRACTExperiments were conducted in this study on the co-hydropyrolysis of three components of biomass (cellulose, hemicellulose, and lignin) and HDPE by using SR-Pd/Trap-HZ-5 as catalyst. To control the variable, we use the same experiment conditions in co-hydropyrolysis: Si/Al ratio of 50, Pd load 1%, catalyst to reactant ratio of 1:10, 1 MPa, 400°C, reaction time 1 h. Use XRD, TEM, BET, and NH3-TPD to confirm catalyst successful synthesis; use pine sawdust (PW) co-hydropyrolysis with HDPE to analyse catalytic activity; and use ...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Long Ren Yupu Xu Wenjun Chen Changsen Zhang Source Type: research
New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682
Chem Biodivers. 2024 Mar 27:e202400584. doi: 10.1002/cbdv.202400584. Online ahead of print.ABSTRACTTwo pairs of new enantiomeric hydroxyphenylacetic acid derivatives, (±)-corylophenols A and B ((±)-1 and (±)-2), a new α-pyrone analogue, corylopyrone A (3), and six andrastin-type meroterpenoids (4-9) were isolated and identified from the deep-sea cold-seep sediment-derived fungus Penicillium corylophilum CS-682. Their structures and stereo configurations were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis, J-based configuration analysis, and quantum chemical calculations of ECD, s...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Chi-Sheng Zhu Xiao-Ming Li Sui-Qun Yang Yi-Wei Liu Bin-Gui Wang Xin Li Source Type: research
Taxodin A, a Cytotoxic C30 Terpenoid from Taxodium mucronatum with a Unique Skeleton
Chem Biodivers. 2024 Mar 28:e202400648. doi: 10.1002/cbdv.202400648. Online ahead of print.ABSTRACTTaxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC50 values of 15.35...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Yao Li Zhi-Ping Zhou Li-Ting Chen Source Type: research
A Review on traditional uses, phytochemistry, pharmacology and clinical application of Tinospora sinensis (Lour.) Merr
Chem Biodivers. 2024 Mar 28:e202302037. doi: 10.1002/cbdv.202302037. Online ahead of print.ABSTRACTTinospora sinensis (T. sinensis), whose Tibetan name is "Lezhe", as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti-inflammatory, analgesic, immunosuppressive, anti-aging, anti-radiation, anti-...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Yan Liang Shao-Bo Guo Chang Xu Ying-Ying Su Cheng-Yuan Su Wei Zhang Bin Liu Source Type: research
Production of Aromatic Hydrocarbons from Co-hydropyrolysis of Biomass Components and HDPE with Application of Modified HZSM-5 Catalyst
Chem Biodivers. 2024 Mar 28:e202400150. doi: 10.1002/cbdv.202400150. Online ahead of print.ABSTRACTExperiments were conducted in this study on the co-hydropyrolysis of three components of biomass (cellulose, hemicellulose, and lignin) and HDPE by using SR-Pd/Trap-HZ-5 as catalyst. To control the variable, we use the same experiment conditions in co-hydropyrolysis: Si/Al ratio of 50, Pd load 1%, catalyst to reactant ratio of 1:10, 1 MPa, 400°C, reaction time 1 h. Use XRD, TEM, BET, and NH3-TPD to confirm catalyst successful synthesis; use pine sawdust (PW) co-hydropyrolysis with HDPE to analyse catalytic activity; and use ...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Long Ren Yupu Xu Wenjun Chen Changsen Zhang Source Type: research
New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682
Chem Biodivers. 2024 Mar 27:e202400584. doi: 10.1002/cbdv.202400584. Online ahead of print.ABSTRACTTwo pairs of new enantiomeric hydroxyphenylacetic acid derivatives, (±)-corylophenols A and B ((±)-1 and (±)-2), a new α-pyrone analogue, corylopyrone A (3), and six andrastin-type meroterpenoids (4-9) were isolated and identified from the deep-sea cold-seep sediment-derived fungus Penicillium corylophilum CS-682. Their structures and stereo configurations were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis, J-based configuration analysis, and quantum chemical calculations of ECD, s...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Chi-Sheng Zhu Xiao-Ming Li Sui-Qun Yang Yi-Wei Liu Bin-Gui Wang Xin Li Source Type: research
Taxodin A, a Cytotoxic C30 Terpenoid from Taxodium mucronatum with a Unique Skeleton
Chem Biodivers. 2024 Mar 28:e202400648. doi: 10.1002/cbdv.202400648. Online ahead of print.ABSTRACTTaxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC50 values of 15.35...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Yao Li Zhi-Ping Zhou Li-Ting Chen Source Type: research
A Review on traditional uses, phytochemistry, pharmacology and clinical application of Tinospora sinensis (Lour.) Merr
Chem Biodivers. 2024 Mar 28:e202302037. doi: 10.1002/cbdv.202302037. Online ahead of print.ABSTRACTTinospora sinensis (T. sinensis), whose Tibetan name is "Lezhe", as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti-inflammatory, analgesic, immunosuppressive, anti-aging, anti-radiation, anti-...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Yan Liang Shao-Bo Guo Chang Xu Ying-Ying Su Cheng-Yuan Su Wei Zhang Bin Liu Source Type: research
Production of Aromatic Hydrocarbons from Co-hydropyrolysis of Biomass Components and HDPE with Application of Modified HZSM-5 Catalyst
Chem Biodivers. 2024 Mar 28:e202400150. doi: 10.1002/cbdv.202400150. Online ahead of print.ABSTRACTExperiments were conducted in this study on the co-hydropyrolysis of three components of biomass (cellulose, hemicellulose, and lignin) and HDPE by using SR-Pd/Trap-HZ-5 as catalyst. To control the variable, we use the same experiment conditions in co-hydropyrolysis: Si/Al ratio of 50, Pd load 1%, catalyst to reactant ratio of 1:10, 1 MPa, 400°C, reaction time 1 h. Use XRD, TEM, BET, and NH3-TPD to confirm catalyst successful synthesis; use pine sawdust (PW) co-hydropyrolysis with HDPE to analyse catalytic activity; and use ...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Long Ren Yupu Xu Wenjun Chen Changsen Zhang Source Type: research
New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682
Chem Biodivers. 2024 Mar 27:e202400584. doi: 10.1002/cbdv.202400584. Online ahead of print.ABSTRACTTwo pairs of new enantiomeric hydroxyphenylacetic acid derivatives, (±)-corylophenols A and B ((±)-1 and (±)-2), a new α-pyrone analogue, corylopyrone A (3), and six andrastin-type meroterpenoids (4-9) were isolated and identified from the deep-sea cold-seep sediment-derived fungus Penicillium corylophilum CS-682. Their structures and stereo configurations were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis, J-based configuration analysis, and quantum chemical calculations of ECD, s...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Chi-Sheng Zhu Xiao-Ming Li Sui-Qun Yang Yi-Wei Liu Bin-Gui Wang Xin Li Source Type: research
Taxodin A, a Cytotoxic C30 Terpenoid from Taxodium mucronatum with a Unique Skeleton
Chem Biodivers. 2024 Mar 28:e202400648. doi: 10.1002/cbdv.202400648. Online ahead of print.ABSTRACTTaxodin A (1), a unique C30 terpenoid featuring an unprecedented skeleton composed of an abietane-type diterpene and a menthane-type monoterpene, was obtained from the leaves and branches of Taxodium mucronatum. The structure and absolute configuration of compound 1 was unequivocally established by the combination of extensive spectroscopic analyses and X-ray single-crystal diffraction analysis. Compound 1 exhibited potent cytotoxic activities against A549, SMMC-7721, MDA-MB-231, and SW480 cell lines with IC50 values of 15.35...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Qin-Shi Zhao Yao Li Zhi-Ping Zhou Li-Ting Chen Source Type: research
A Review on traditional uses, phytochemistry, pharmacology and clinical application of Tinospora sinensis (Lour.) Merr
Chem Biodivers. 2024 Mar 28:e202302037. doi: 10.1002/cbdv.202302037. Online ahead of print.ABSTRACTTinospora sinensis (T. sinensis), whose Tibetan name is "Lezhe", as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti-inflammatory, analgesic, immunosuppressive, anti-aging, anti-radiation, anti-...
Source: Chemistry and Biodiversity - March 28, 2024 Category: Biochemistry Authors: Yan Liang Shao-Bo Guo Chang Xu Ying-Ying Su Cheng-Yuan Su Wei Zhang Bin Liu Source Type: research
Network Pharmacology Approach to Identify the Calotropis Phytoconstituents' Potential Epileptic Targets and Evaluation of Molecular Docking, MD Simulation, and MM-PBSA Performance
This study was aimed at investigating the plausible epileptic targets of Calotropis phytoconstituents through network pharmacology, and to evaluate their binding strength and stability with the identified targets. In detail, 125 phytoconstituents of Calotropis plant (C. procera and C. gigantea) were assessed for their drug likeness (DL), blood-brain-barrier (BBB) permeability and oral bioavailability (OB). Network analysis revealed that targets PTGS2 and PPAR-γ were ranked first and fourth, respectively, among the top ten hub genes significantly linked with antiepileptic drug targets. Additionally, docking, molecular dyna...
Source: Chemistry and Biodiversity - March 27, 2024 Category: Biochemistry Authors: Punam Salaria Amarendar Reddy M Source Type: research
