Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells
Channels (Austin). 2023 Dec;17(1):2192377. doi: 10.1080/19336950.2023.2192377.ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of MFS and to identify a potential effective target for attenuating MFS. KEGG enrichment analysis showed that the calcium signaling pathway gene set was significantly enriched. We demonstrated that FBN1 deficiency exhibited inhibition on both the expressio...
Source: Channels - March 27, 2023 Category: Molecular Biology Authors: Wenfeng Lin Jiaqi Xiong Yefan Jiang Hao Liu Jinhui Bian Juejin Wang Yongfeng Shao Buqing Ni Source Type: research
