Sodium currents in na ïve mouse dorsal root ganglion neurons: No major differences between sexes
Channels (Austin). 2024 Dec;18(1):2289256. doi: 10.1080/19336950.2023.2289256. Epub 2023 Dec 6.ABSTRACTSexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neurons display differential sex-dependent regulation and expression patterns of various proteins involved in the pain pathway. Our goal in this study was to determine whether sexual dimorphism in the biophysical properties of voltage-gated sodium (Nav) currents contributes to these observations in rodents. We recently developed a ...
Source: Channels - December 6, 2023 Category: Molecular Biology Authors: Mohammad-Reza Ghovanloo Sidharth Tyagi Peng Zhao Philip R Effraim Sulayman D Dib-Hajj Stephen G Waxman Source Type: research
A structural atlas of druggable sites on Na < sub > v < /sub > channels
Channels (Austin). 2024 Dec;18(1):2287832. doi: 10.1080/19336950.2023.2287832. Epub 2023 Nov 30.ABSTRACTVoltage-gated sodium (Nav) channels govern membrane excitability by initiating and propagating action potentials. Consistent with their physiological significance, dysfunction, or mutations in these channels are associated with various channelopathies. Nav channels are thereby major targets for various clinical and investigational drugs. In addition, a large number of natural toxins, both small molecules and peptides, can bind to Nav channels and modulate their functions. Technological breakthrough in cryo-electron micro...
Source: Channels - November 30, 2023 Category: Molecular Biology Authors: Zhangqiang Li Qiurong Wu Nieng Yan Source Type: research
