Non-canonical helical transitions and conformational switching are associated with characteristic flexibility and disorder indices in TRP and Kv channels
Channels (Austin). 2023 Dec;17(1):2212349. doi: 10.1080/19336950.2023.2212349.ABSTRACTStructural evidence and much experimental data have demonstrated the presence of non-canonical helical substructures (π and 310) in regions of great functional relevance both in TRP as in Kv channels. Through an exhaustive compositional analysis of the sequences underlying these substructures, we find that each of them is associated with characteristic local flexibility profiles, which in turn are implicated in significant conformational rearrangements and interactions with specific ligands. We found that α-to-π helical transitions are...
Source: Channels - May 17, 2023 Category: Molecular Biology Authors: Abigail Garc ía-Morales Daniel Balleza Source Type: research
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility
Channels (Austin). 2023 Dec;17(1):2212350. doi: 10.1080/19336950.2023.2212350.ABSTRACTThe Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction. Nav1.9 channels also participate in regulating intestinal motility. Functional enhancements of Nav1.9 channels to a certain extent lead to hyperexc...
Source: Channels - May 15, 2023 Category: Molecular Biology Authors: Chenyu Zhao Xi Zhou Xiaoliu Shi Source Type: research
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility
Channels (Austin). 2023 Dec;17(1):2212350. doi: 10.1080/19336950.2023.2212350.ABSTRACTThe Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel II neurons in enteric nervous system. The small diameter neurons in dorsal root ganglions are the primary sensory neurons of pain conduction. Nav1.9 channels also participate in regulating intestinal motility. Functional enhancements of Nav1.9 channels to a certain extent lead to hyperexc...
Source: Channels - May 15, 2023 Category: Molecular Biology Authors: Chenyu Zhao Xi Zhou Xiaoliu Shi Source Type: research
Identification of SLC2A3 as a prognostic indicator correlated with the NF- κB/EMT axis and immune response in head and neck squamous cell carcinoma
In conclusion, our study demonstrated that SLC2A3 could predict the prognosis of HNSC patients and mediate the progression of HNSC via the NF-κB/EMT axis and immune responses.PMID:37134043 | PMC:PMC10158547 | DOI:10.1080/19336950.2023.2208928 (Source: Channels)
Source: Channels - May 3, 2023 Category: Molecular Biology Authors: Fangyu Chai Jingfang Zhang Tao Fu Peng Jiang Yichuan Huang Lin Wang Shu Yan Xudong Yan Longgang Yu Zhen Xu Ruohuang Wang Bingqing Xu Xiaoyun Du Yan Jiang Jisheng Zhang Source Type: research
Identification of SLC2A3 as a prognostic indicator correlated with the NF- κB/EMT axis and immune response in head and neck squamous cell carcinoma
In conclusion, our study demonstrated that SLC2A3 could predict the prognosis of HNSC patients and mediate the progression of HNSC via the NF-κB/EMT axis and immune responses.PMID:37134043 | DOI:10.1080/19336950.2023.2208928 (Source: Channels)
Source: Channels - May 3, 2023 Category: Molecular Biology Authors: Fangyu Chai Jingfang Zhang Tao Fu Peng Jiang Yichuan Huang Lin Wang Shu Yan Xudong Yan Longgang Yu Zhen Xu Ruohuang Wang Bingqing Xu Xiaoyun Du Yan Jiang Jisheng Zhang Source Type: research
A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels
Channels (Austin). 2023 Dec;17(1):2191773. doi: 10.1080/19336950.2023.2191773.ABSTRACTOne of nature's exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion selectivity filter. The HFS+1 site is dubbed a "beacon" for its location at the entryway just above the constricted, minimum radius of the HFS site's electronegative ring. A classification is proposed based on the occupancy of the HFS+1 "beacon" which correlates with the calcium- or sodium-selectivi...
Source: Channels - April 25, 2023 Category: Molecular Biology Authors: J David Spafford Source Type: research
