The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
Molecular pharmacology of the onco-TRP channel TRPV6
Channels (Austin). 2023 Dec;17(1):2266669. doi: 10.1080/19336950.2023.2266669. Epub 2023 Oct 15.ABSTRACTTRPV6, a representative of the vanilloid subfamily of TRP channels, serves as the principal calcium uptake channel in the gut. Dysregulation of TRPV6 results in disturbed calcium homeostasis leading to a variety of human diseases, including many forms of cancer. Inhibitors of this oncochannel are therefore particularly needed. In this review, we provide an overview of recent advances in structural pharmacology that uncovered the molecular mechanisms of TRPV6 inhibition by a variety of small molecules, including synthetic...
Source: Channels - October 15, 2023 Category: Molecular Biology Authors: Arthur Neuberger Alexander I Sobolevsky Source Type: research
