A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions
Channels (Austin). 2023 Dec;17(1):2273008. doi: 10.1080/19336950.2023.2273008. Epub 2023 Nov 7.ABSTRACTMonocarboxylate transporters (MCTs) play an immense role in metabolically active solid tumors by regulating concentration-dependent transport of different important monocarboxylates including pyruvate and lactate and are encoded by the SLC16A family of genes. Given the vast array of functions, these transporters play in oncogenesis, our objective was to look into the association of MCT1 (SLC16A1), MCT2 (SLC16A7), MCT3 (SLC16A8), and MCT4 (SLC16A3) with Epithelial ovarian cancer (EOC) pathophysiology by exploiting various ...
Source: Channels - November 7, 2023 Category: Molecular Biology Authors: Priti Chatterjee Debaleena Bhowmik Sib Sankar Roy Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
The role of ATP binding cassette (ABC) transporters in breast cancer: Evaluating prognosis, predicting immunity, and guiding treatment
Channels (Austin). 2023 Dec;17(1):2273247. doi: 10.1080/19336950.2023.2273247. Epub 2023 Oct 31.ABSTRACTBreast cancer is currently the most prevalent form of cancer worldwide. Nevertheless, there remains limited clarity regarding our understanding of the tumor microenvironment and metabolic characteristics associated with it. ATP-binding cassette (ABC) transporters are the predominant transmembrane transporters found in organisms. Therefore, it is essential to investigate the role of ABC transporters in breast cancer. Transcriptome data from breast cancer patients were downloaded from the TCGA database. ABC transporter-rel...
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Yuan Yuan Zhouhong Xiang Yuhua Xia Jiaheng Xie Xiudi Jiang Zhicheng Lu Source Type: research
Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels
This article summarizes recent advances in CNG channel structural biology, describes key structural features and elements, and illuminates a detailed conformational landscape of activation by cyclic nucleotides. The review also correlates structures with findings and properties delineated in functional studies, including nonselective monovalent cation selectivity, Ca2+ permeation and block, block by L-cis-diltiazem, location of the activation gate, lack of voltage-dependent gating, and modulation by lipids and calmodulin. A perspective on future research is also offered.PMID:37905307 | DOI:10.1080/19336950.2023.2273165 (Source: Channels)
Source: Channels - October 31, 2023 Category: Molecular Biology Authors: Zhengshan Hu Jian Yang Source Type: research
