TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism
Channels (Austin). 2023 Dec;17(1):2237306. doi: 10.1080/19336950.2023.2237306.ABSTRACTTMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be necessary for sensing mechanical pain. TMEM120A's ion channel function has subsequently been challenged, as attempts to replicate electrophysiological experiments have largely been unsuccessful. Several cryo-EM structures revealed TMEM120A is structurally homologous to a lipid modifying enzyme called Elonga...
Source: Channels - July 31, 2023 Category: Molecular Biology Authors: Matthew Gabrielle Tibor Rohacs Source Type: research
Advancements in the study of inward rectifying potassium channels on vascular cells
Channels (Austin). 2023 Dec;17(1):2237303. doi: 10.1080/19336950.2023.2237303.ABSTRACTInward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved in maintaining resting membrane potential and signal transduction in most cells, as well as connecting metabolism and membrane excitability of body cells. It is closely related to normal physiological functions of body and the occurrence and development of some diseases. Although the functional expression of Kir channels and their role in disease have been studied, they have not been fully elucidated. In this paper, the functional expression of...
Source: Channels - July 18, 2023 Category: Molecular Biology Authors: Chunshu Li Yan Yang Source Type: research
Advancements in the study of inward rectifying potassium channels on vascular cells
Channels (Austin). 2023 Dec;17(1):2237303. doi: 10.1080/19336950.2023.2237303.ABSTRACTInward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved in maintaining resting membrane potential and signal transduction in most cells, as well as connecting metabolism and membrane excitability of body cells. It is closely related to normal physiological functions of body and the occurrence and development of some diseases. Although the functional expression of Kir channels and their role in disease have been studied, they have not been fully elucidated. In this paper, the functional expression of...
Source: Channels - July 18, 2023 Category: Molecular Biology Authors: Chunshu Li Yan Yang Source Type: research
Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels
Channels (Austin). 2023 Dec;17(1):2230776. doi: 10.1080/19336950.2023.2230776.ABSTRACTMissense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson's disease. We recently documented the importance of SCAMP2 in the regulation of T-type calcium channel expression in the plasma membrane. Here, we show that similar to SCAMP2, the co-expression of SCAMP5 in tsA-201 cells expressing recombinant Cav3.1, Cav3.2, and Cav3.3 channels nearly abolished whole-cell T-type currents. Recording of intramembrane c...
Source: Channels - June 30, 2023 Category: Molecular Biology Authors: Emilio R Mustaf á Konstantin Wei ß Norbert Weiss Source Type: research
