The early detection of atherosclerosis in type 1 diabetes: why, how and what to do about it
The major cause of morbidity and often premature mortality in people with type I diabetes (T1D) is cardiovascular disease owing to accelerated atherosclerosis. We review publications relating to the rationale behind, and clinical tests for, detecting and treating early atherosclerosis in people with T1D. Currently available tools for atherosclerosis assessment include risk equations using vascular risk factors, arterial intima–media thickness, the ankle–brachial index, coronary artery calcification and angiography, and for more advanced lesions, intravascular ultrasound and optical coherence tomography. Evolving resear...
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Review articles Source Type: research
Recent trends over time in vascular disease in type 1 diabetes: insights from the Pittsburgh Epidemiology of Diabetes Complications study
Conclusion
Despite declines in all-cause, cardiovascular and renal mortality in the total cohort, no improvements were observed in either mortality or complication incidence with a more recent onset in the examined cohort. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Review articles Source Type: research
Cardiovascular disease in type 1 diabetes: the elephant in the clinic
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Editorial Source Type: research
Abstracts
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Abstracts: PDF Only Source Type: research
Association between thyroid abnormalities and hypertension among hospitalized US patients: data from the National Inpatient Sample
Abnormalities of thyroid, namely hyperthyroidism and hypothyroidism, are both associated with increased risk of hypertension. We utilized the National Inpatient Sample from the years 2012–2014 to explore the risk of thyroid disorders in relation to those without a thyroid diagnosis. We found that hypertension was more commonly associated with hyperthyroidism (odds ratio: 1.18; 95% confidence interval: 1.16–1.21, P (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Short report Source Type: research
Vitamin D status in acute myocardial infarction: a case–control study
This study seeks the association between vitamin D deficiency and acute myocardial infarction (MI) in Iraq.
Patients and methods
A total of 104 patients with acute MI and 104 healthy controls were studied throughout 2015. Their demographic, cardiovascular risk factors, and clinical characteristics were recorded. Serum vitamin D measurement was carried out for all patients.
Results
Vitamin D was more deficient in cases than controls; the number of cases was 60 (57.7%) and 53 (51%), respectively. However, a statistically significant difference (P=0.6) was not obtained. In the patient group, type 2 diabetes mellitus sho...
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Original articles Source Type: research
Association between asymmetric dimethylarginine serum levels and left ventricular longitudinal deformation in patients with normal ejection fractions: a two-dimensional speckle-tracking echocardiography examination
Conclusion
Our findings showed no statistically significant correlations between the serum ADMA level and the 2DSTE-derived indices of the longitudinal deformation of the LV myocardium in our nondiabetic patients without significant coronary artery stenosis and with normal LV ejection fractions. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Original articles Source Type: research
Serum leptin in male hypothyroid prediabetic patients: Association with cardiovascular risk
Conclusion
Hypothyroidism is associated with high serum leptin independent of prediabetic state. Serum leptin in hypothyroid prediabetic patients showed a direct relationship with some primary markers of metabolic syndrome; thus, leptin may predict the development of CHD in those patients. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Original articles Source Type: research
Development of clinical trials to extend healthy lifespan
We describe the rationale and collaborative, consensus building approach used to design the first aging outcome trial called Targeting Aging with Metformin. Through this case study, we outline features that could be more broadly extended to other geroscience-guided clinical trials, including a process for selecting biochemical and molecular markers of biologic age and we provide a perspective on the potential impact of clinical trials targeting aging. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Review articles Source Type: research
In-vivo metabolic studies of regional adipose tissue
The accumulation of abdominal adipose tissue has long been associated with adverse cardiovascular outcomes. Paradoxically, increased gluteofemoral adipose tissue, which is predominantly subcutaneous fat, seems to play a protective role. There has been significant scientific interest in understanding how abdominal and gluteofemoral depots confer opposing metabolic risks. However, the study of regional adipose physiology in vivo remains challenging. We discuss some of the methodologies used. We focus specifically on the arteriovenous difference technique and present some insights into gluteofemoral adipose physiology. (Sourc...
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Review articles Source Type: research
26th Annual Meeting of the European Group for the study of Insulin Resistance, Lille, France, 7–8th June 2018
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Editorials Source Type: research
Diabetes: learning from the past 25 years and looking to the future
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 7, 2018 Category: Cardiology Tags: Editorials Source Type: research
Type 2 diabetes and susceptibility to atrial fibrillation: the two facets of downregulation of MiR-126?
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2018 Category: Cardiology Tags: Correspondence Source Type: research
Is diabetes mellitus equivalent to atherosclerotic cardiovascular disease from a healthcare cost perspective? Insights from the Medical Expenditure Panel Survey: 2010–2013
Diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD) both increase the risk for a major adverse cardiac event, and are therefore considered priority conditions clinically. Although guidelines encourage clinicians to treat them similarly, many researchers do not consider DM an ASCVD risk-equivalent. However, from a healthcare system standpoint it is more important to determine whether DM is an economic burden equivalent to ASCVD. Using data from the Household Component of the 2010–2013 Medical Expenditure Panel Survey, we determined that the diagnosis of DM yields significantly lower healthcare expend...
Source: Cardiovascular Endocrinology - August 12, 2018 Category: Cardiology Tags: Short Report Source Type: research
Interaction between cardiovascular autonomic control and sex hormones in perimenopausal women under menopausal hormone therapy
Conclusion
The obtained results may indicate the independence of heart autonomic control (assessed by HRV measures) from women’s hormonal status. However, any changes in sex hormones contribute to changes in the systemic control of circulation, which is assessed by index S. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2018 Category: Cardiology Tags: Original Article Source Type: research
