Hormonal and metabolic profiles of obese and nonobese type 2 diabetes patients: implications of plasma insulin, ghrelin, and vitamin D levels
In this study, 408 T2D patients were recruited in three distinct studies conducted in Bahrain, Saudi Arabia, and Kuwait in three different intervals between 2001 and 2019. In addition to demographics, glycemic and lipid profiles were obtained in all studies, whereas plasma insulin and HOMA-IR, vitamin D, and ghrelin were analyzed in Saudi Arabia. Different techniques such as chemical auto-analyzer, ELISA, chemiluminescent immunoassay, radioimmunoassay were used.
Results
The obese (BMI ≥ 30 kg/m2) compared with nonobese (BMI 18.5 to (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - February 18, 2022 Category: Cardiology Tags: Original article Source Type: research
The risk factors potentially influencing risk of serious illness/death in people with diabetes, following SARS-CoV-2 infection: What needs to be done from here
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Correspondence Source Type: research
Atypical hemolytic uremic syndrome: when pregnancy leads to lifelong dialysis: a case report and literature review
We present a case of a young 18-year-old woman with MAHA and aHUS, requiring emergent cesarean section at 34 weeks of gestation and hemodialysis, secondary to complications from a recent pregnancy. Elevated blood pressure readings, rising creatinine levels, as well as her mother being on dialysis after pregnancy raised suspicion for thrombotic microangiopathy and aHUS. She was subsequently managed with plasma exchange, steroids, eculizumab and hemodialysis. Thus, plasma exchange should be initiated, with pending additional workup. Upon a definitive diagnosis of aHUS, eculizumab would be warranted to mitigate immune dysregu...
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Case report Source Type: research
Successful use of the sodium-glucose co-transporter-2 inhibitor dapagliflozin in patients with renal transplant and diabetes: a case series and literature review
Conclusion
Use of the SGLT-2 inhibitor dapagliflozin in the standard dose of 10 mg helped to achieve satisfactory control with favorable effects on BP and weight with no adverse effects on renal function. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Short report Source Type: research
Genetic association of LPL rs326 with BMI among the Kuwaiti population
This study was performed to investigate the association between common lipoprotein lipase single nucleotide polymorphisms and metabolic disorders in a sample of Kuwaiti cohort (n = 494). Five lipoprotein lipase variants (rs1801177, rs295, rs326, ss2137497749, and ss2137497750) across the lipoprotein lipase gene were genotyped by real-time PCR employing the TaqMan allele discrimination assay. Genotype, allelic frequencies, and Hardy-Weinberg Equilibrium were determined for each variant in the cohort followed by multivariate and logistic regression analysis. A novel finding was observed for the G allele of single nucleotide ...
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Original articles Source Type: research
Correlation between the ankle–brachial index and microalbuminuria with certain risk factors in type 2 diabetes patients
Conclusions
Peripheral vascular disease risk factors such as hypertension, dyslipidemia and waist circumference and the effectiveness of fasting blood glucose and HbA1c control increased the risk of high microalbuminuria and ABI in patients with type 2 diabetes. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Original articles Source Type: research
Acute cardiac overload does not induce cardiac or skeletal expression of fibroblast growth factor 23 in rats
Conclusions
Acute cardiac overload by saline injection in rats did neither induce FGF23 expression in the heart or bone nor did it increase serum FGF23 levels. These findings suggest that more severe or long-term cardiac damage is required for induction of FGF23 expression. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Original articles Source Type: research
The microvascular hypothesis underlying neurologic manifestations of long COVID-19 and possible therapeutic strategies
With the ongoing distribution of the coronavirus disease (COVID) vaccines, the pandemic of our age is ending, leaving the world to deal with its well-documented aftereffects. Long COVID comprises a variety of symptoms, of which the neurological component prevails. The most permeating theory on the genesis of these symptoms builds upon the development of microvascular dysfunction similar to that seen in numerous vascular diseases such as diabetes. This can occur through the peripheral activation of angiotensin-converting enzyme 2 receptors, or through exacerbations of pro-inflammatory cytokines that can remain in circulatio...
Source: Cardiovascular Endocrinology - November 18, 2021 Category: Cardiology Tags: Review article Source Type: research
Low sex hormone binding globulin: a potential predictor of future glucose dysregulation in women
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Correspondence Source Type: research
Evaluation of diastolic function in newly diagnosed hyperthyroid patients with preserved left ventricular systolic function
Conclusion
Our finding did not show diastolic dysfunction in hyperthyroid patients neither at rest nor during exercise echocardiography and did not support the hypothesis that diastolic dysfunction can be a cause of exertional intolerance and dyspnea in the patients with preserved EF. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Original Articles Source Type: research
Speckle tracking echocardiographic assessment of left ventricular longitudinal strain in female patients with subclinical hyperthyroidism
Conclusions
Patients with SCH have deteriorated global strain in comparison to healthy controls. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Original Articles Source Type: research
Novel biomarkers for subtle myocardial involvement in type I diabetes mellitus
Conclusion
CT-1 has proven to be a diagnostic superiority in LV systolic dysfunction whilst BNP continues to prove every day through our study and through many others that it is the chief marker of diastolic dysfunction and HFpEF. This potential accuracy and the increasing availability of BNP in the outpatient setting make it clear that it should be used as a screening test for diabetic patients. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Original Articles Source Type: research
Cardiometabolic medicine: a review of the current proposed approaches to revamped training in the United States
Cardiovascular disease (CVD) remains the leading cause of mortality in the United States, and the population of patients with cardiometabolic conditions, including obesity, metabolic syndrome and diabetes mellitus, continues to grow. There is a need for physicians with specific training in cardiometabolic medicine to provide a ‘medical home’ for patients with cardiometabolic disease, rather than the fractured care that currently exists in the United States. Cardiometabolic specialists will head multidisciplinary clinics, develop practice guidelines, and lead through research. Proposals for US training in cardiometaboli...
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Review Source Type: research
Salivary markers and coronavirus disease 2019: insights from cross-talk between the oral microbiome and pulmonary and systemic low-grade inflammation and implications for vascular complications
To date, coronavirus disease 2019 (COVID-19) has affected over 6.2 million individuals worldwide, including 1.46 million deaths. COVID-19 complications are mainly induced by low-grade inflammation-causing vascular degeneration. There is an increasing body of evidence that suggests that oral dysbiotic taxa are associated with worse prognosis in COVID-19 patients, especially the Prevotella genus, which was retrieved from nasopharyngeal and bronchoalveolar lavage samples in affected patients. Oral dysbiosis may act by increasing the likelihood of vascular complications through low-grade inflammation, as well as impairing resp...
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Review Source Type: research
The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever
Regular exercise causes chronic adaptations in anatomy/physiology that provide first-line defense for disease prevention/treatment (‘exercise is medicine’). However, transient changes in function that occur following each exercise bout (acute effect) are also important to consider. For example, in contrast to chronic adaptations, the effect of exercise on insulin sensitivity is predominantly rooted in a prolonged acute effect (PAE) that can last up to 72 h. Untrained individuals and individuals with lower insulin sensitivity benefit more from this effect and even trained individuals with high insulin sensitivity rest...
Source: Cardiovascular Endocrinology - August 12, 2021 Category: Cardiology Tags: Review Source Type: research
