Testosterone replacement and cardiovascular disease risk: what do endocrinologists need to know?
Testosterone deficiency (or hypogonadism) affects millions of men worldwide. Consensus regarding an appropriate biochemical cutoff for the definition and treatment of hypogonadism has been challenging. Several recent, well-publicized studies have called into question the long recognized benefits of testosterone replacement therapy. The aim of the current article is to review the data on testosterone treatment, paying specific attention to the potential cardiovascular effects of this increasingly common therapy. We examine some of the most common cardiovascular diseases including hypertension, metabolic syndrome, coronary a...
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Invited reviews Source Type: research
Effects of testosterone replacement on glucose and lipid metabolism
Testosterone levels have become a much more available and frequent screening test in clinical practice. There is greater awareness of testosterone deficiency symptoms both among the medical community and among the patients themselves. Several studies have described the effects of testosterone on carbohydrate and lipid metabolism and the disturbances that occur in patients with hypogonadism. However, whether testosterone replacement reverts such alterations is less clear. In this article, we review the effects of testosterone replacement therapy on glucose and lipid metabolism. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Invited reviews Source Type: research
Testosterone replacement therapy: the controversies of cardiovascular risk
This article reviews studies focusing on recent trials of testosterone replacement therapy on cardiovascular risk. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Review articles Source Type: research
Relevance of low testosterone to nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a condition where there is excess accumulation of triglycerides in the liver in the absence of excess alcohol consumption. It ranges from simple steatosis to nonalcoholic steatohepatitis, which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, one of the most common causes of chronic liver disease in Western populations, is the hepatic component of the metabolic syndrome and is associated with increased visceral adipose tissue (VAT), insulin resistance, and dyslipidemia. Studies have also shown that testosterone deficiency is associated with increased VAT ...
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Review articles Source Type: research
Defining the best candidates for testosterone replacement?
It is widely known that re-establishing physiologic levels of testosterone in symptomatic men with testosterone deficiency (TD) improves the undesirable symptoms associated with low testosterone. The indications for testosterone replacement therapy (TRT) have been evolving as research continues to find out who are the best candidates for therapy. Recently, concerns on the association of TRT and cardiovascular disease have received considerable attention. Before this, considerable attention had focused on the potential dangers of TRT and the risk of prostate cancer. The vast majority of contemporary evidence suggests that m...
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Review articles Source Type: research
Testosterone, metabolism, and cardiovascular disease
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - August 14, 2015 Category: Cardiology Tags: Editorial Source Type: research
Diiodothyropropionic acid in the management of cardiovascular disease
Conclusion: DITPA appears to be promising in enhancing cardiac output and hemodynamic stability for heart failure patients, with possible synergistic implications when combined with other heart failure medications. However, extensive human trials are needed to establish its role in the management of heart failure and establish its safety profile. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 13, 2015 Category: Cardiology Tags: Review Source Type: research
Bariatric surgery in obese older people: useful or not?
Conclusion: Bariatric surgery in older people is effective in reducing complications of obesity, but is also associated with increased rates of complications compared with those seen in younger patients. The few reported studies in the elderly are retrospective, generally small, primarily describe findings of laparoscopic adjustable gastric banding as the surgical intervention option and lack long-term follow-up. More trials and registry data, especially for sleeve gastrectomy and gastric bypass, are required to better address the utility of bariatric surgery in the elderly and to define long-term clinical outcomes. (Sourc...
Source: Cardiovascular Endocrinology - May 13, 2015 Category: Cardiology Tags: Original articles Source Type: research
Blood pressure and body size preference in traditional communities of Ilorin metropolis, Nigeria
Background: Our previous work showed that many individuals with type 2 diabetes and in the background population may prefer larger body sizes. This prompted us to study the interaction between body size, body size perception and blood pressure.
Methods: Anthropometric variables, body size perception and blood pressure were measured in adults of three Nigerian communities. The results were subjected to tests of correlation and regression to determine any association/functional relationship between predictor variables and blood pressure.
Results: Participants with elevated blood pressure were older (52.75 vs. 39.58 years) an...
Source: Cardiovascular Endocrinology - May 13, 2015 Category: Cardiology Tags: Original articles Source Type: research
Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation Study
Conclusion: In women with signs and symptoms of ischemia and no obstructive CAD, MetS is associated with coronary atherosclerosis presence and severity. However, these associations appear largely driven by components of waist circumference and systolic blood pressure versus MetS cluster. This supports the concept that MetS is a convenient clustering of risk factors rather than an independent risk predictor, and emphasizes that the critical factors for coronary atherosclerosis are potentially modifiable. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 13, 2015 Category: Cardiology Tags: Original articles Source Type: research
The components of metabolic syndrome in women: ‘Is the whole really greater than the sum of its parts?’
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 13, 2015 Category: Cardiology Tags: Editorial Source Type: research
Association of pheochromocytoma and primary hyperaldosteronism in a 50-year-old man
In conclusion, the association of pheochromocytoma and primary hyperaldosteronism can present in the same patient and needs to be considered on the basis of the clinical and biochemical findings. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - February 10, 2015 Category: Cardiology Tags: Case report Source Type: research
A novel application of salivary testosterone in systolic heart failure: relationship with exercise capacity, quality of life and cardiac mechanics
Conclusion: ST can be used as an alternative marker of traditional testosterone parameters in HF without semi-invasive blood sampling. There is a correlation between exercise capacity and physical quality of life domains with all testosterone fractions. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - February 10, 2015 Category: Cardiology Tags: Original articles Source Type: research
sP-selectin is a useful biomarker for cardiovascular risk: findings from an elderly primary healthcare population
Conclusion: sP-selectin is a prognostic biomarker for mortality in an elderly primary healthcare population. Compared with NT-proBNP, sP-selectin is at least as effective. We therefore suggest sP-selectin as an additional biomarker to be used in assessing the elderly to identify those at risk of cardiovascular events. The results presented should be considered hypothesis-generating, and warrant more research. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - February 10, 2015 Category: Cardiology Tags: Original articles Source Type: research
Metformin: new perspectives for an old antidiabetic drug
This articles summarizes the molecular mechanisms of the action of metformin as well as potential new indications for this well-known drug. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - February 10, 2015 Category: Cardiology Tags: Review articles Source Type: research
