Further insights into cardiovascular outcomes in diabetic and non-diabetic states: inhibition of sodium-glucose co-transports
Cardiovascular diseases are the leading cause of morbidity and mortality in the world. Diabetes increase heart disease related to death by two- to four-fold. SGLT2 inhibitors are new antidiabetic agents. The growing evidence of cardiovascular benefit of SGLT2 inhibitors independent of their effects on glycemic control is especially intriguing. Several clinical trials have shown that sotagliflozin (SGLT1-1/2 inhibitor) decreases body weight and reduces blood pressure in adults with T2D. A phase 3 study designed to evaluate cardiovascular outcomes of sotagliflozin is currently ongoing. Many pre-clinical studies were conducte...
Source: Cardiovascular Endocrinology - November 8, 2019 Category: Cardiology Tags: Review Articles Source Type: research
27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Short Report Source Type: research
Association of neutrophil-gelatinase-associated lipocalin with microvascular complications in patients with type 2 diabetes: a cross-sectional study
Conclusion
There are controversial findings about the role of NGAL in diabetic patients in medical literature. Standard values of urine and serum NGAL levels have yet to be determined. Our study suggests that NGAL is not a useful marker to differentiate microalbuminuric patients from normoalbuminuric subjects. We also did not find a relationship between NGAL levels and the presence of retinopathy. Additional studies with larger sample sizes will be required to confirm or refute these findings. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Original Articles Source Type: research
Relative fat mass is a better predictor of dyslipidemia and metabolic syndrome than body mass index
Background
Relative fat mass (RFM) had been recently developed. We aimed to examine RFM predictability to various cardiometabolic risk factors, compared to BMI.
Methods
Observational, cohort study, among patients who visited the Rambam Periodic Examinations Institute (RPEI). We compared the correlation of BMI and RFM to hypertension, impaired fasting glucose, high LDL, low HDL and metabolic syndrome, by gender.
Results
During study years, 20 167 patients visited the RPEI and included in the trial. Compared to BMI, RFM showed significantly better predictability (odds ratio [OR], [95% confidence interval (CI), P valu...
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Original Articles Source Type: research
Association of lipid peroxidation and interleukin-6 with carotid atherosclerosis in type 2 diabetes
Aim
Enhanced lipid peroxidation and elevated interleukin-6 levels are common in type 2 diabetes mellitus patients. Atherosclerotic vascular complications greatly contribute to morbidity and mortality in diabetes. The aim of this study was to assess the relation of lipid peroxidation and interleukin-6 with carotid atherosclerosis in type 2 diabetes mellitus.
Methods
This cross-sectional study included 90 type 2 diabetes mellitus male patients with age ≥ 40 years and 30 healthy male subjects matched for age. All of them were subjected to measuring of 8-iso prostaglandin F2α as a marker of lipid peroxidation, interleu...
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Original Articles Source Type: research
Addressing the impact of type 2 diabetes in ageing populations: the launch of the 2019 Endocrine Society Task Force Guideline
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Commentary Source Type: research
Elizabeth Barrett-Connor (1935–2019): an appreciation
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - September 1, 2019 Category: Cardiology Tags: Appreciation Source Type: research
DiRECT and indirect paths to reducing cardiovascular risk in diabetes: insights from Diabetes UK 2019
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 2, 2019 Category: Cardiology Tags: Short Report Source Type: research
Correlation between the serum procalcitonin level and the extension and severity of coronary artery disease in patients with non-ST-segment elevation myocardial infarction
Conclusion
The second 24-h postadmission serum PCT level was not correlated with the severity and extension of CAD according to the Gensini score in our patients with NSTEMI. (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 2, 2019 Category: Cardiology Tags: Original Article Source Type: research
Atherosclerosis: integration of its pathogenesis as a self-perpetuating propagating inflammation: a review
This review proposes that the development of the atherosclerotic plaque is critically dependent on its inflammatory components forming a self-perpetuating and propagating positive feedback loop. The components involved are: (1) LDL oxidation, (2) activation of the endothelium, (3) recruitment of inflammatory monocytes, (4) macrophage accumulation, which induces LDL oxidation, and (5) macrophage generation of inflammatory mediators, which also activate the endothelium. Through these stages, the positive feedback loop is formed, which generates and promotes expansion of the atherosclerotic process. To illustrate this dynamic...
Source: Cardiovascular Endocrinology - May 2, 2019 Category: Cardiology Tags: Review Source Type: research
Vascular disease and type 2 diabetes: the science policy case for early cardiometabolic intervention
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 2, 2019 Category: Cardiology Tags: Editorials Source Type: research
Cardiometabolic medicine: time to recognize a new clinical specialty?
No abstract available (Source: Cardiovascular Endocrinology)
Source: Cardiovascular Endocrinology - May 2, 2019 Category: Cardiology Tags: Editorials Source Type: research
Vascular disease in the lower limb in type 1 diabetes
This review considers peripheral arterial disease (PAD) in the diabetic ischaemic lower limb including both macrovascular and microvascular aspects. The presentation of PAD is probably not significantly different in type 1 compared with type 2 diabetes. PAD in diabetic patients is diffuse and located distally being most severe in the crural and also the foot arteries. It is associated with arterial calcification and occlusion of the arteries rather than stenosis. Compared with the nondiabetic patient, PAD develops at a younger age, and women are equally affected as men. It is not known whether the presentation of ischaemic...
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Review articles Source Type: research
Type 1 diabetes mellitus and coronary revascularization
Over the last three decades, trials of coronary revascularization have taken into account whether populations did or did not have diabetes. What has not been considered is whether or not patients with diabetes in these studies have type 1 or type 2 diabetes. ‘Diabetes’ appears to be largely used as a synonym for type 2 diabetes. The number of patients with type 1 diabetes has not been reported in most trials. Many questions remain unanswered. Do patients with type 1 diabetes have the same response to various modes of revascularization as those with type 2 diabetes? We know type 2 diabetes affects coronary endothelial f...
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Review articles Source Type: research
Cardiovascular disease in type 1 diabetes
Cardiovascular disease (CVD) is a well-recognized complication of diabetes. Although the association of type 2 diabetes with CVD has been well described, the mechanisms, risk stratification and screening strategies of CVD in type 1 diabetes (T1D) are less understood. This review aims to evaluate recent literature and guidelines regarding CVD in T1D. At the cellular level, the early stage of CVD is characterized by endothelial dysfunction. Recent studies have shown that endothelial function is unaffected in younger T1D patients but there is a significant degree of endothelial dysfunction in the older T1D population compared...
Source: Cardiovascular Endocrinology - March 1, 2019 Category: Cardiology Tags: Review articles Source Type: research
