Further insights into cardiovascular outcomes in diabetic and non-diabetic states: inhibition of sodium-glucose co-transports

Cardiovascular diseases are the leading cause of morbidity and mortality in the world. Diabetes increase heart disease related to death by two- to four-fold. SGLT2 inhibitors are new antidiabetic agents. The growing evidence of cardiovascular benefit of SGLT2 inhibitors independent of their effects on glycemic control is especially intriguing. Several clinical trials have shown that sotagliflozin (SGLT1-1/2 inhibitor) decreases body weight and reduces blood pressure in adults with T2D. A phase 3 study designed to evaluate cardiovascular outcomes of sotagliflozin is currently ongoing. Many pre-clinical studies were conducted to investigate the potential mechanisms involved in cardiovascular benefits of SGLT1 or SGLT2 inhibition with or without diabetes. Although multiple mechanisms have been proposed, there are still not enough data to fully support the mechanisms of actions. This review aims to discuss the potential mechanisms involved in cardiovascular benefits of SGLT1 and SGLT2 inhibition in both diabetic and non-diabetic states.
Source: Cardiovascular Endocrinology - Category: Cardiology Tags: Review Articles Source Type: research

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Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology and risk factors Source Type: research
Multiple factors, including increasing incidence, poor knowledge of stroke and lack of effective, noninvasive and convenient stroke risk prediction tools, make it more difficult for precautions against stroke in China. Effective prediction models for stroke may assist to establish better risk awareness and management, healthier lifestyle, and lower stroke incidence for people. The China Health and Retirement Longitudinal Survey was the development cohort. Logistic regression was applied to model's development, in which the candidate variables with statistically significant coefficient were included in the prediction model...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: NUTRITION AND PHYSIOLOGICAL FUNCTION: Edited by Annemie M.W.J. Schols and Labros S. Sidossis Source Type: research
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Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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Source: Cardiology in Review - Category: Cardiology Tags: Invited Review Articles Source Type: research
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide. Risk factors of CVD can be classified into modifiable (smoking, hypertension, diabetes, hypercholesterolemia) through lifestyle changes or taking drug therapy and not modifiable (age, ethnicity, sex and family history). Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels have a lead role in the development of coronary heart disease (CHD), while high levels of high-density lipoprotein-cholesterol (HDL-C) seem to have a protective role. The current treatment for dyslipidemia consists of lifestyle modification or drug...
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Review Source Type: research
It is well known that individuals with type 2 diabetes (T2D) have a higher incidence of heart failure than those without.(1) Less is known, however, about the relationship between impaired glucose tolerance (IGT) and heart failure incidence, and whether treating IGT to delay or prevent development of T2D might reduce the incidence of heart failure. China has one of the highest rates of IGT and new-onset T2D in the world.(2) In addition, the China Heart Survey showed that the prevalence of IGT is significantly higher in individuals with coronary heart disease (CHD), compared with those without CHD.(3) Thus, the combination ...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Alzheimer-disease brain pathology Cognitive-impairment cognitive-reserve cognitive-stimulation dementia JAMA neurodegeneration neurology neuropathology occupa Source Type: blogs
In this issue of the Journal, a group of distinguished Nordic researchers, led by Anne Helene Garde and including four of our Associated Editors, present a discussion paper that originated from a workshop and provides detailed recommendations on night shift work (1). The recommendations are very clear: to protect workers ’ health, night shift schedules should have: (i) ≤3 consecutive night shifts; (ii) shift intervals of ≥11 hours; and (iii) ≤9 hours shift duration. For pregnant women, night work should be limited to one shift per week. The authors acknowledge that under circumstances allowing better possibi...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
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