Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
In this study, we identified PIK3CA mutant (PIK3CA MT) as a determinant of resistance to SMI-4a, a highly selective PIM1 kinase inhibitor, in CRC cell lines. In CRC cell lines, SMI-4a showed its effect only in PIK3CA wild type (PIK3CA WT) cell lines, while PIK3CA MT cells did not respond to SMI-4a in cell death assays. In vivo xenograft and PDX experiments confirmed that PIK3CA MT is responsible for the resistance to SMI-4a. Inhibition of PIK3CA MT by PI3K inhibitors restored SMI-4a sensitivity in PIK3CA MT CRC cell lines. Taken together, these results demonstrate that sensitivity to SMI-4a is determined by the PIK3CA geno...
Source: Cancer Biology and Therapy - August 25, 2023 Category: Cancer & Oncology Authors: Yoon Sun Park Joseph Kim Yea Seong Ryu Jai-Hee Moon Yu Jin Shin Jeong Hee Kim Seung-Woo Hong Soo-A Jung Seul Lee Seung-Mi Kim Dae Hee Lee Do Yeon Kim Hyeseon Yun Ji-Eun You Dong Il Yoon Chul Hee Kim Dong-In Koh Dong-Hoon Jin Source Type: research
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Cancer Biol Ther. 2023 Dec 31;24(1):2246205. doi: 10.1080/15384047.2023.2246205.ABSTRACTCircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed by the GEO database and qRT‒PCR. The biological function and underlying molecular mechanism of circSETD2 in BC were explored using in vitro and in vivo experiments, including CCK8, transwell, RIP, western blot, and xenograft mouse models. The expression of circSETD2 was downregulated ...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Lan Jing Liu Yang Cao Jianbo Wan Yuqiu Zhou Yehui Source Type: research
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2246206. doi: 10.1080/15384047.2023.2246206.ABSTRACTTranscription factor 3 (TCF3) is a member of the basic Helix - Loop - Helix (bHLH) transcription factor (TF) family and is encoded by the TCF3 gene (also known as E2A). It has been shown that TCF3 functions as a key transcription factor in the pathogenesis of several human cancers and plays an important role in stem cell maintenance and carcinogenesis. However, the effect of TCF3 in the progression of esophageal squamous cell carcinoma (ESCC) is poorly known. In our study, TCF3 was found to express highly and correlated with cancer stag...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Zhao-Xing Li Ming-Chuang Sun Kang Fang Zi-Ying Zhao Zhu-Yun Leng Ze-Hua Zhang Ai-Ping Xu Yuan Chu Li Zhang Jingjing Lian Tao Chen Mei-Dong Xu Source Type: research
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Cancer Biol Ther. 2023 Dec 31;24(1):2246205. doi: 10.1080/15384047.2023.2246205.ABSTRACTCircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed by the GEO database and qRT‒PCR. The biological function and underlying molecular mechanism of circSETD2 in BC were explored using in vitro and in vivo experiments, including CCK8, transwell, RIP, western blot, and xenograft mouse models. The expression of circSETD2 was downregulated ...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Lan Jing Liu Yang Cao Jianbo Wan Yuqiu Zhou Yehui Source Type: research
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2246206. doi: 10.1080/15384047.2023.2246206.ABSTRACTTranscription factor 3 (TCF3) is a member of the basic Helix - Loop - Helix (bHLH) transcription factor (TF) family and is encoded by the TCF3 gene (also known as E2A). It has been shown that TCF3 functions as a key transcription factor in the pathogenesis of several human cancers and plays an important role in stem cell maintenance and carcinogenesis. However, the effect of TCF3 in the progression of esophageal squamous cell carcinoma (ESCC) is poorly known. In our study, TCF3 was found to express highly and correlated with cancer stag...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Zhao-Xing Li Ming-Chuang Sun Kang Fang Zi-Ying Zhao Zhu-Yun Leng Ze-Hua Zhang Ai-Ping Xu Yuan Chu Li Zhang Jingjing Lian Tao Chen Mei-Dong Xu Source Type: research
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Cancer Biol Ther. 2023 Dec 31;24(1):2246205. doi: 10.1080/15384047.2023.2246205.ABSTRACTCircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed by the GEO database and qRT‒PCR. The biological function and underlying molecular mechanism of circSETD2 in BC were explored using in vitro and in vivo experiments, including CCK8, transwell, RIP, western blot, and xenograft mouse models. The expression of circSETD2 was downregulated ...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Lan Jing Liu Yang Cao Jianbo Wan Yuqiu Zhou Yehui Source Type: research
Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy
This study employed label-free LC-MS/MS to identify 14-3-3ε-associated proteins in CRC cells treated with or without Tp. Our results confirmed that heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C) were exported out of the nucleus by 14-3-3ε and degraded by ubiquitination. The nucleo-cytoplasmic shuttling of 14-3-3ε carrying hnRNP C mediated Tp-induced proliferation inhibition, cell cycle arrest and autophagic processes. These findings have broad implications for our understanding of 14-3-3ε function, provide an explanation for the mechanism of nucleo-cytoplasmic shuttling of hnRNP C and provide new insights int...
Source: Cancer Biology and Therapy - August 21, 2023 Category: Cancer & Oncology Authors: Manlan Guo Minyi He Yi Zhang Weiwen Liu Min Qi Zhifeng Liu Guozhong Yi Shengze Deng Yaomin Li Xuegang Sun Liang Zhao Tengxiang Chen Yawei Liu Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | PMC:PMC10431729 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | PMC:PMC10431729 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | PMC:PMC10431729 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | PMC:PMC10431729 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis
CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | DOI:10.1080/15384047.2023.2235770 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research
A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis
CONCLUSION: MALAT1 downregulated DNMT1 by miR-137/BCL11A pathway to enhance TNBC stemness and tumorigenesis; meanwhile, DNMT1/MALAT1 formed a positive feedback loop to continuously promote TNBC malignant behaviors.PMID:37548553 | PMC:PMC10408694 | DOI:10.1080/15384047.2023.2235768 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 7, 2023 Category: Cancer & Oncology Authors: Yu Hu Yuqiong He Na Luo Xin Li Lei Guo Kejing Zhang Source Type: research
A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis
CONCLUSION: MALAT1 downregulated DNMT1 by miR-137/BCL11A pathway to enhance TNBC stemness and tumorigenesis; meanwhile, DNMT1/MALAT1 formed a positive feedback loop to continuously promote TNBC malignant behaviors.PMID:37548553 | PMC:PMC10408694 | DOI:10.1080/15384047.2023.2235768 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 7, 2023 Category: Cancer & Oncology Authors: Yu Hu Yuqiong He Na Luo Xin Li Lei Guo Kejing Zhang Source Type: research
