The relationship between long non-coding gene < em > CASC21 < /em > polymorphisms and cervical cancer
CONCLUSION: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.PMID:38465665 | DOI:10.1080/15384047.2024.2322207 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi Source Type: research
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer
Cancer Biol Ther. 2024 Dec 31;25(1):2325130. doi: 10.1080/15384047.2024.2325130. Epub 2024 Mar 11.ABSTRACTEmerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an essential fatty acid with the highest consumption in the Western diet regimen, has shown pro-tumorigenic or anti-tumorigenic effects on tumor cell growth and invasion in multiple types of cancer. However, the biological role of linoleic acid in endometrial cancer remains unclear. In the present study, we aimed to investigate...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Jianqing Qiu Ziyi Zhao Hongyan Suo Sarah E Paraghamian Gabrielle M Hawkins Wenchuan Sun Xin Zhang Tianran Hao Beor Deng Xiaochang Shen Chunxiao Zhou Victoria Bae-Jump Source Type: research
Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
Cancer Biol Ther. 2024 Dec 31;25(1):2323768. doi: 10.1080/15384047.2024.2323768. Epub 2024 Mar 11.ABSTRACTDouble minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression. After screening for SUMO-related molecule expression within various tumor sample and cell line databases, we found that SUMO-conjugating enzyme UBC9 has been associated with genome instability and tumor cell DM counts, which was confirmed both in vitro and in vivo. Karyotyping determined DM counts post-UBC9 knockdown or SUMOylatio...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Yusi Wang Hongyan Zou Wei Ji Min Huang Benhui You Nan Sun Yuandong Qiao Peng Liu Lidan Xu Xuelong Zhang Mengdi Cai Ye Kuang Songbin Fu Wenjing Sun Xueyuan Jia Jie Wu Source Type: research
Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Cancer Biol Ther. 2024 Dec 31;25(1):2323765. doi: 10.1080/15384047.2024.2323765. Epub 2024 Mar 11.ABSTRACTAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to th...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Source Type: research
The relationship between long non-coding gene < em > CASC21 < /em > polymorphisms and cervical cancer
CONCLUSION: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.PMID:38465665 | DOI:10.1080/15384047.2024.2322207 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi Source Type: research
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer
Cancer Biol Ther. 2024 Dec 31;25(1):2325130. doi: 10.1080/15384047.2024.2325130. Epub 2024 Mar 11.ABSTRACTEmerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an essential fatty acid with the highest consumption in the Western diet regimen, has shown pro-tumorigenic or anti-tumorigenic effects on tumor cell growth and invasion in multiple types of cancer. However, the biological role of linoleic acid in endometrial cancer remains unclear. In the present study, we aimed to investigate...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Jianqing Qiu Ziyi Zhao Hongyan Suo Sarah E Paraghamian Gabrielle M Hawkins Wenchuan Sun Xin Zhang Tianran Hao Beor Deng Xiaochang Shen Chunxiao Zhou Victoria Bae-Jump Source Type: research
Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
Cancer Biol Ther. 2024 Dec 31;25(1):2323768. doi: 10.1080/15384047.2024.2323768. Epub 2024 Mar 11.ABSTRACTDouble minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression. After screening for SUMO-related molecule expression within various tumor sample and cell line databases, we found that SUMO-conjugating enzyme UBC9 has been associated with genome instability and tumor cell DM counts, which was confirmed both in vitro and in vivo. Karyotyping determined DM counts post-UBC9 knockdown or SUMOylatio...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Yusi Wang Hongyan Zou Wei Ji Min Huang Benhui You Nan Sun Yuandong Qiao Peng Liu Lidan Xu Xuelong Zhang Mengdi Cai Ye Kuang Songbin Fu Wenjing Sun Xueyuan Jia Jie Wu Source Type: research
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3- β pathway
Cancer Biol Ther. 2024 Dec 31;25(1):2321770. doi: 10.1080/15384047.2024.2321770. Epub 2024 Mar 5.ABSTRACTGBM is one of the most malignant tumor in central nervous system. The resistance to temozolomide (TMZ) is inevitable in GBM and the characterization of TMZ resistance seriously hinders clinical treatment. It is worthwhile exploring the underlying mechanism of aggressive invasion and TMZ resistance in GBM treatment. Bioinformatic analysis was used to analyze the association between RND1 and a series of EMT-related genes. Colony formation assay and cell viability assay were used to assess the growth of U87 and U251 cells....
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Qian Sun Junjie Xu Fan'en Yuan Yan Liu Qianxue Chen Lirui Guo Huimin Dong Baohui Liu Source Type: research
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation
Cancer Biol Ther. 2024 Dec 31;25(1):2325126. doi: 10.1080/15384047.2024.2325126. Epub 2024 Mar 6.ABSTRACTOvarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associated with malignant disease progression in a variety of cancers, its mechanistic functions in OC have yet to be firmly established. We explored the role of TOP2A in OC through online databases, clinical samples, in vitro and in vivo experiments. And initial analyses of public databases...
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Kaiwen Zhang Xingyu Zheng Yiqing Sun Xinyu Feng Xirong Wu Wenlu Liu Chao Gao Ye Yan Wenyan Tian Yingmei Wang Source Type: research
Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
Cancer Biol Ther. 2024 Dec 31;25(1):2317999. doi: 10.1080/15384047.2024.2317999. Epub 2024 Mar 6.ABSTRACTRectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy, and immunotherapy. Radiotherapy, specifically external beam radiation therapy, is the most common way to treat rectal cancer because radiation not only limits cancer progression but also significantly reduces the risk of local recurrence. However, therapeutic radiation-induced radioresistance to rectal cancer cells and toxici...
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Samatha M Jain Shruthi Nagainallur Ravichandran Makalakshmi Murali Kumar Antara Banerjee Alexander Sun-Zhang Hong Zhang Rupak Pathak Xiao-Feng Sun Surajit Pathak Source Type: research
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3- β pathway
Cancer Biol Ther. 2024 Dec 31;25(1):2321770. doi: 10.1080/15384047.2024.2321770. Epub 2024 Mar 5.ABSTRACTGBM is one of the most malignant tumor in central nervous system. The resistance to temozolomide (TMZ) is inevitable in GBM and the characterization of TMZ resistance seriously hinders clinical treatment. It is worthwhile exploring the underlying mechanism of aggressive invasion and TMZ resistance in GBM treatment. Bioinformatic analysis was used to analyze the association between RND1 and a series of EMT-related genes. Colony formation assay and cell viability assay were used to assess the growth of U87 and U251 cells....
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Qian Sun Junjie Xu Fan'en Yuan Yan Liu Qianxue Chen Lirui Guo Huimin Dong Baohui Liu Source Type: research
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation
Cancer Biol Ther. 2024 Dec 31;25(1):2325126. doi: 10.1080/15384047.2024.2325126. Epub 2024 Mar 6.ABSTRACTOvarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associated with malignant disease progression in a variety of cancers, its mechanistic functions in OC have yet to be firmly established. We explored the role of TOP2A in OC through online databases, clinical samples, in vitro and in vivo experiments. And initial analyses of public databases...
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Kaiwen Zhang Xingyu Zheng Yiqing Sun Xinyu Feng Xirong Wu Wenlu Liu Chao Gao Ye Yan Wenyan Tian Yingmei Wang Source Type: research
Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
Cancer Biol Ther. 2024 Dec 31;25(1):2317999. doi: 10.1080/15384047.2024.2317999. Epub 2024 Mar 6.ABSTRACTRectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy, and immunotherapy. Radiotherapy, specifically external beam radiation therapy, is the most common way to treat rectal cancer because radiation not only limits cancer progression but also significantly reduces the risk of local recurrence. However, therapeutic radiation-induced radioresistance to rectal cancer cells and toxici...
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Samatha M Jain Shruthi Nagainallur Ravichandran Makalakshmi Murali Kumar Antara Banerjee Alexander Sun-Zhang Hong Zhang Rupak Pathak Xiao-Feng Sun Surajit Pathak Source Type: research
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3- β pathway
Cancer Biol Ther. 2024 Dec 31;25(1):2321770. doi: 10.1080/15384047.2024.2321770. Epub 2024 Mar 5.ABSTRACTGBM is one of the most malignant tumor in central nervous system. The resistance to temozolomide (TMZ) is inevitable in GBM and the characterization of TMZ resistance seriously hinders clinical treatment. It is worthwhile exploring the underlying mechanism of aggressive invasion and TMZ resistance in GBM treatment. Bioinformatic analysis was used to analyze the association between RND1 and a series of EMT-related genes. Colony formation assay and cell viability assay were used to assess the growth of U87 and U251 cells....
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Qian Sun Junjie Xu Fan'en Yuan Yan Liu Qianxue Chen Lirui Guo Huimin Dong Baohui Liu Source Type: research
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation
Cancer Biol Ther. 2024 Dec 31;25(1):2325126. doi: 10.1080/15384047.2024.2325126. Epub 2024 Mar 6.ABSTRACTOvarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associated with malignant disease progression in a variety of cancers, its mechanistic functions in OC have yet to be firmly established. We explored the role of TOP2A in OC through online databases, clinical samples, in vitro and in vivo experiments. And initial analyses of public databases...
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Kaiwen Zhang Xingyu Zheng Yiqing Sun Xinyu Feng Xirong Wu Wenlu Liu Chao Gao Ye Yan Wenyan Tian Yingmei Wang Source Type: research
