Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia
Cancer Biol Ther. 2023 Dec 31;24(1):2285801. doi: 10.1080/15384047.2023.2285801. Epub 2023 Nov 30.ABSTRACTTo explore the clinical significance and prognosis of acute myeloid leukemia (AML) patients with WT1 mutations.In total, the clinical data of 269 adult patients with non-M3 AML were considered retrospectively. From these patients, 153 carried WT1 mutation whereas 116 were negative. WT1 mutation positive patients were further divided into WT1 low expression and high expression groups base on the expression level of WT1 by qPCR at diagnosis (cut off: 170500). Survival and therapeutic effect analysis were performed for th...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Tingyu Yu Qian Zhan Xinyu Yan Xiaohua Luo Xin Wang Xiaoqiong Tang Hongbin Zhang Zesong Yang Jianbin Chen Lin Liu Li Wang Source Type: research
Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma
CONCLUSION: In this study, we presented the prevalence rates of PD-L1 expression in Chinese ESCC patients. The association of genetic profiles with PD-L1 expression levels also provide the clue that genomic phenotype may interact with the immunologic phenotype in ESCC.PMID:38032149 | PMC:PMC10515684 | DOI:10.1080/15384047.2023.2256927 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Songchen Zhao Xintong Hu Peiwen Zhou Ang Li Liguo Chen Duo Wang Jiaxue He Yanfang Jiang Source Type: research
Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy
Cancer Biol Ther. 2023 Dec 31;24(1):2285367. doi: 10.1080/15384047.2023.2285367. Epub 2023 Nov 30.ABSTRACTImmunotherapy of lung cancer has achieved promising clinical results. However, it is urgent to develop predictive biomarkers for effective immunotherapy. While ferroptosis plays a critical role in immunotherapy efficacy, ferritin is an important regulatory factor. We, therefore, hypothesize that basal serum ferritin levels before immunotherapy and their corresponding changes during immunotherapy can be useful predictors of immunotherapy response in patients with lung cancer. We measured serum ferritin levels in 107 pat...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Fei Wang Guodong Deng Ning Liang Pingping Hu Kuo Liu Tong Liu Yang Li Meng Yuan Li Liu Jian Xie Lili Qiao Fengjun Liu Jiandong Zhang Source Type: research
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
This study elucidated how CDK2 antagonism affected centrosome stoichiometry. Focused ion beam scanning electron microscopy (FIB-SEM) and immunofluorescent imaging were used. Studies interrogated multipolar mitosis after pharmacologic or genetic repression of CDK2. CDK2/9 antagonism with CYC065 (Fadraciclib)-treatment disordered centrosome stoichiometry in aneuploid cancer cells, preventing centrosome clustering. This caused ring-like chromosomes or multipolar cancer cells to form before onset of cell death. Intriguingly, CDK2 inhibition caused a statistically significant increase in single centrioles rather than intact cen...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Zibo Chen Xi Liu Masanori Kawakami Xiuxia Liu Allison Baker Aayush Bhatawadekar Liliya Tyutyunyk-Massey Kedar Narayan Ethan Dmitrovsky Source Type: research
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia
Cancer Biol Ther. 2023 Dec 31;24(1):2285801. doi: 10.1080/15384047.2023.2285801. Epub 2023 Nov 30.ABSTRACTTo explore the clinical significance and prognosis of acute myeloid leukemia (AML) patients with WT1 mutations.In total, the clinical data of 269 adult patients with non-M3 AML were considered retrospectively. From these patients, 153 carried WT1 mutation whereas 116 were negative. WT1 mutation positive patients were further divided into WT1 low expression and high expression groups base on the expression level of WT1 by qPCR at diagnosis (cut off: 170500). Survival and therapeutic effect analysis were performed for th...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Tingyu Yu Qian Zhan Xinyu Yan Xiaohua Luo Xin Wang Xiaoqiong Tang Hongbin Zhang Zesong Yang Jianbin Chen Lin Liu Li Wang Source Type: research
Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma
CONCLUSION: In this study, we presented the prevalence rates of PD-L1 expression in Chinese ESCC patients. The association of genetic profiles with PD-L1 expression levels also provide the clue that genomic phenotype may interact with the immunologic phenotype in ESCC.PMID:38032149 | PMC:PMC10515684 | DOI:10.1080/15384047.2023.2256927 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Songchen Zhao Xintong Hu Peiwen Zhou Ang Li Liguo Chen Duo Wang Jiaxue He Yanfang Jiang Source Type: research
Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy
Cancer Biol Ther. 2023 Dec 31;24(1):2285367. doi: 10.1080/15384047.2023.2285367. Epub 2023 Nov 30.ABSTRACTImmunotherapy of lung cancer has achieved promising clinical results. However, it is urgent to develop predictive biomarkers for effective immunotherapy. While ferroptosis plays a critical role in immunotherapy efficacy, ferritin is an important regulatory factor. We, therefore, hypothesize that basal serum ferritin levels before immunotherapy and their corresponding changes during immunotherapy can be useful predictors of immunotherapy response in patients with lung cancer. We measured serum ferritin levels in 107 pat...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Fei Wang Guodong Deng Ning Liang Pingping Hu Kuo Liu Tong Liu Yang Li Meng Yuan Li Liu Jian Xie Lili Qiao Fengjun Liu Jiandong Zhang Source Type: research
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
This study elucidated how CDK2 antagonism affected centrosome stoichiometry. Focused ion beam scanning electron microscopy (FIB-SEM) and immunofluorescent imaging were used. Studies interrogated multipolar mitosis after pharmacologic or genetic repression of CDK2. CDK2/9 antagonism with CYC065 (Fadraciclib)-treatment disordered centrosome stoichiometry in aneuploid cancer cells, preventing centrosome clustering. This caused ring-like chromosomes or multipolar cancer cells to form before onset of cell death. Intriguingly, CDK2 inhibition caused a statistically significant increase in single centrioles rather than intact cen...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Zibo Chen Xi Liu Masanori Kawakami Xiuxia Liu Allison Baker Aayush Bhatawadekar Liliya Tyutyunyk-Massey Kedar Narayan Ethan Dmitrovsky Source Type: research
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia
Cancer Biol Ther. 2023 Dec 31;24(1):2285801. doi: 10.1080/15384047.2023.2285801. Epub 2023 Nov 30.ABSTRACTTo explore the clinical significance and prognosis of acute myeloid leukemia (AML) patients with WT1 mutations.In total, the clinical data of 269 adult patients with non-M3 AML were considered retrospectively. From these patients, 153 carried WT1 mutation whereas 116 were negative. WT1 mutation positive patients were further divided into WT1 low expression and high expression groups base on the expression level of WT1 by qPCR at diagnosis (cut off: 170500). Survival and therapeutic effect analysis were performed for th...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Tingyu Yu Qian Zhan Xinyu Yan Xiaohua Luo Xin Wang Xiaoqiong Tang Hongbin Zhang Zesong Yang Jianbin Chen Lin Liu Li Wang Source Type: research
Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma
CONCLUSION: In this study, we presented the prevalence rates of PD-L1 expression in Chinese ESCC patients. The association of genetic profiles with PD-L1 expression levels also provide the clue that genomic phenotype may interact with the immunologic phenotype in ESCC.PMID:38032149 | PMC:PMC10515684 | DOI:10.1080/15384047.2023.2256927 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Songchen Zhao Xintong Hu Peiwen Zhou Ang Li Liguo Chen Duo Wang Jiaxue He Yanfang Jiang Source Type: research
Serum ferritin level is an effective prognostic factor for lung cancer immunotherapy
Cancer Biol Ther. 2023 Dec 31;24(1):2285367. doi: 10.1080/15384047.2023.2285367. Epub 2023 Nov 30.ABSTRACTImmunotherapy of lung cancer has achieved promising clinical results. However, it is urgent to develop predictive biomarkers for effective immunotherapy. While ferroptosis plays a critical role in immunotherapy efficacy, ferritin is an important regulatory factor. We, therefore, hypothesize that basal serum ferritin levels before immunotherapy and their corresponding changes during immunotherapy can be useful predictors of immunotherapy response in patients with lung cancer. We measured serum ferritin levels in 107 pat...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Fei Wang Guodong Deng Ning Liang Pingping Hu Kuo Liu Tong Liu Yang Li Meng Yuan Li Liu Jian Xie Lili Qiao Fengjun Liu Jiandong Zhang Source Type: research
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells
This study elucidated how CDK2 antagonism affected centrosome stoichiometry. Focused ion beam scanning electron microscopy (FIB-SEM) and immunofluorescent imaging were used. Studies interrogated multipolar mitosis after pharmacologic or genetic repression of CDK2. CDK2/9 antagonism with CYC065 (Fadraciclib)-treatment disordered centrosome stoichiometry in aneuploid cancer cells, preventing centrosome clustering. This caused ring-like chromosomes or multipolar cancer cells to form before onset of cell death. Intriguingly, CDK2 inhibition caused a statistically significant increase in single centrioles rather than intact cen...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Zibo Chen Xi Liu Masanori Kawakami Xiuxia Liu Allison Baker Aayush Bhatawadekar Liliya Tyutyunyk-Massey Kedar Narayan Ethan Dmitrovsky Source Type: research
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia
Cancer Biol Ther. 2023 Dec 31;24(1):2285801. doi: 10.1080/15384047.2023.2285801. Epub 2023 Nov 30.ABSTRACTTo explore the clinical significance and prognosis of acute myeloid leukemia (AML) patients with WT1 mutations.In total, the clinical data of 269 adult patients with non-M3 AML were considered retrospectively. From these patients, 153 carried WT1 mutation whereas 116 were negative. WT1 mutation positive patients were further divided into WT1 low expression and high expression groups base on the expression level of WT1 by qPCR at diagnosis (cut off: 170500). Survival and therapeutic effect analysis were performed for th...
Source: Cancer Biology and Therapy - November 30, 2023 Category: Cancer & Oncology Authors: Tingyu Yu Qian Zhan Xinyu Yan Xiaohua Luo Xin Wang Xiaoqiong Tang Hongbin Zhang Zesong Yang Jianbin Chen Lin Liu Li Wang Source Type: research
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model
This study investigated the effects of LPS-stimulated inflammation on cell proliferation, levels of pro-inflammatory cytokines, and the NLRP3 inflammasome pathway in a co-culture model using PDAC cells and macrophages in the presence or absence of MCC950, a NLRP3-specific inhibitor. The effects of LPS-stimulated inflammation were tested on two PDAC cell lines (Panc 10.05 and SW 1990) co-cultured with RAW 264.7 macrophages. Cell proliferation was determined using the MTT assay. Levels of pro-inflammatory cytokines, IL-1β, and TNF-α were determined by ELISA. Western blot analyses were used to examine the expression of NLRP...
Source: Cancer Biology and Therapy - November 29, 2023 Category: Cancer & Oncology Authors: Hariss G Paremes Sivam Beek Yoke Chin Sook Yee Gan Jia Hao Ng Agnes Gwenhure Elaine Wan Ling Chan Source Type: research
Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives
Cancer Biol Ther. 2023 Dec 31;24(1):2285817. doi: 10.1080/15384047.2023.2285817. Epub 2023 Nov 27.ABSTRACTThe function of Vasohibin-1 (VASH1) in human cancer has not been thoroughly or comprehensively examined. Here, we identified the tumor suppressor part of VASH1 across cancers, including epithelial ovarian tumors. Our study carefully contrasted the expression of VASH1 in pancancer and nontumorous tissues in a public database to explore its regulatory role in clinical prognosis, diagnosis, tumor purity, and immune cell infiltration. Next, we explored the antitumor mechanism of VASH1 through drug sensitivity, functional e...
Source: Cancer Biology and Therapy - November 27, 2023 Category: Cancer & Oncology Authors: Yan Li Liang Meng Ge Lou Source Type: research
