hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression
This study aimed to investigate a novel circRNA, hsa_circ_0020378 (circ_0020378), and elucidate its functions and underlying mechanisms during osteosarcoma progression. The expression levels of circ_0020378, miR-339-3p, and COL1A1 in osteosarcoma cells and tissues were determined using RT-qPCR or Western blotting. CCK8, transwell migration, colony formation, and xenograft experiments were performed to assess the malignancy of osteosarcoma cells. Luciferase and RNA immunoprecipitation (RIP) experiments were employed to validate the interactions of miR-339-3p with circ_0020378 and COL1A1 3'UTR. Osteosarcoma cells and tissues...
Source: Cancer Biology and Therapy - November 18, 2023 Category: Cancer & Oncology Authors: Liang Liu Wenze Huang Source Type: research
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis
Cancer Biol Ther. 2023 Dec 31;24(1):2274121. doi: 10.1080/15384047.2023.2274121. Epub 2023 Nov 15.ABSTRACTThis research aimed to assess the effectiveness of combining induction chemotherapy (IC) or adjuvant chemotherapy (AC) with concurrent chemoradiotherapy (CCRT) in patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC). Before propensity score matching(PSM),we retrospectively collected 457 patients with T3-4N0-1M0 NPC treated with CCRT with or without IC/AC. PSM method selected 285 patients from two cohort(148 in CCRT±IC/AC group,137 in CCRT group). The 3-year overall survival(OS), locoregional relapse-free survival (...
Source: Cancer Biology and Therapy - November 15, 2023 Category: Cancer & Oncology Authors: Qiulu Zhong Danjing Luo Xiangde Li Qinghua Du Qianfu Liang Wenqi Liu Jian Li Xiaodong Zhu Source Type: research
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis
Cancer Biol Ther. 2023 Dec 31;24(1):2274121. doi: 10.1080/15384047.2023.2274121. Epub 2023 Nov 15.ABSTRACTThis research aimed to assess the effectiveness of combining induction chemotherapy (IC) or adjuvant chemotherapy (AC) with concurrent chemoradiotherapy (CCRT) in patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC). Before propensity score matching(PSM),we retrospectively collected 457 patients with T3-4N0-1M0 NPC treated with CCRT with or without IC/AC. PSM method selected 285 patients from two cohort(148 in CCRT±IC/AC group,137 in CCRT group). The 3-year overall survival(OS), locoregional relapse-free survival (...
Source: Cancer Biology and Therapy - November 15, 2023 Category: Cancer & Oncology Authors: Qiulu Zhong Danjing Luo Xiangde Li Qinghua Du Qianfu Liang Wenqi Liu Jian Li Xiaodong Zhu Source Type: research
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis
Cancer Biol Ther. 2023 Dec 31;24(1):2274121. doi: 10.1080/15384047.2023.2274121. Epub 2023 Nov 15.ABSTRACTThis research aimed to assess the effectiveness of combining induction chemotherapy (IC) or adjuvant chemotherapy (AC) with concurrent chemoradiotherapy (CCRT) in patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC). Before propensity score matching(PSM),we retrospectively collected 457 patients with T3-4N0-1M0 NPC treated with CCRT with or without IC/AC. PSM method selected 285 patients from two cohort(148 in CCRT±IC/AC group,137 in CCRT group). The 3-year overall survival(OS), locoregional relapse-free survival (...
Source: Cancer Biology and Therapy - November 15, 2023 Category: Cancer & Oncology Authors: Qiulu Zhong Danjing Luo Xiangde Li Qinghua Du Qianfu Liang Wenqi Liu Jian Li Xiaodong Zhu Source Type: research
Higher PD-1/Tim-3 expression on IFN- γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia
In this study, we first characterized the percentage of PD-1+ and T cell immunoglobulin mucin-domain-containing-3 (Tim-3) +IFN-γ+ T cells in peripheral blood (PB) in AML compared with healthy individuals (HIs) by flow cytometry and further discussed the possibility of the reversal of T cell exhaustion to restore the secretion capacity of cytokines in T cells in AML based on blockade of PD-1 or Tim-3 (anti-PD-1 and anti-Tim-3 antibody) in vitro using a cytokine protein chip. A significantly increased percentage of PD-1+, Tim-3+, and PD-1+Tim-3+ IFN-γ+ T cells was observed in PB from patients with AML in comparison with HI...
Source: Cancer Biology and Therapy - November 14, 2023 Category: Cancer & Oncology Authors: Shuxin Huang Yujie Zhao Wenpu Lai Jiaxiong Tan Xue Zheng Xianfeng Zha Yangqiu Li Shaohua Chen Source Type: research
Higher PD-1/Tim-3 expression on IFN- γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia
In this study, we first characterized the percentage of PD-1+ and T cell immunoglobulin mucin-domain-containing-3 (Tim-3) +IFN-γ+ T cells in peripheral blood (PB) in AML compared with healthy individuals (HIs) by flow cytometry and further discussed the possibility of the reversal of T cell exhaustion to restore the secretion capacity of cytokines in T cells in AML based on blockade of PD-1 or Tim-3 (anti-PD-1 and anti-Tim-3 antibody) in vitro using a cytokine protein chip. A significantly increased percentage of PD-1+, Tim-3+, and PD-1+Tim-3+ IFN-γ+ T cells was observed in PB from patients with AML in comparison with HI...
Source: Cancer Biology and Therapy - November 14, 2023 Category: Cancer & Oncology Authors: Shuxin Huang Yujie Zhao Wenpu Lai Jiaxiong Tan Xue Zheng Xianfeng Zha Yangqiu Li Shaohua Chen Source Type: research
Clinical application of molecular residual disease detection by circulation tumor DNA in solid cancers and a comparison of technologies: review article
Cancer Biol Ther. 2023 Dec 31;24(1):2274123. doi: 10.1080/15384047.2023.2274123. Epub 2023 Nov 13.ABSTRACTMolecular residual disease (MRD), detected by circulating tumor DNA (ctDNA) can be involved in the entire process of solid tumor management, including recurrence prediction, efficacy evaluation, and risk stratification. Currently, the detection technologies are divided into two main categories, as follows: tumor-agnostic and tumor informed. Tumor-informed assay obtains mutation information by sequencing tumor tissue samples before blood MRD monitoring, followed by formulation of a personalized MRD panel. Tumor-agnostic...
Source: Cancer Biology and Therapy - November 13, 2023 Category: Cancer & Oncology Authors: Qiantong Dong Chenbin Chen Yuanbo Hu Weiteng Zhang Xinxin Yang Yingxue Qi Chan Zhu Xiaodong Chen Xian Shen Weiping Ji Source Type: research
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA
This study aimed to make an investigation into the role of NAT10-mediated ac4C modification in the malignant processes of LSCC cells. The NAT10 expression in LSCC tissues and cells was detected RT-qPCR and western blot. The ac4C dot blot was performed to detect ac4C level. Besides, the cell viability, migration, and invasion abilities were detected by CCK-8 and transwell assays. AcRIP-qPCR was performed to measure the abundance of ac4C on FOXM1 mRNA. RIP and Luciferase reporter assays were performed to demonstrate the interaction between NAT10 and FOXM1. Finally, the xenograft model was established to explore the role of N...
Source: Cancer Biology and Therapy - November 10, 2023 Category: Cancer & Oncology Authors: Zengpei Li Dajun Li Tianbin Yang Chen Yao Source Type: research
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA
This study aimed to make an investigation into the role of NAT10-mediated ac4C modification in the malignant processes of LSCC cells. The NAT10 expression in LSCC tissues and cells was detected RT-qPCR and western blot. The ac4C dot blot was performed to detect ac4C level. Besides, the cell viability, migration, and invasion abilities were detected by CCK-8 and transwell assays. AcRIP-qPCR was performed to measure the abundance of ac4C on FOXM1 mRNA. RIP and Luciferase reporter assays were performed to demonstrate the interaction between NAT10 and FOXM1. Finally, the xenograft model was established to explore the role of N...
Source: Cancer Biology and Therapy - November 10, 2023 Category: Cancer & Oncology Authors: Zengpei Li Dajun Li Tianbin Yang Chen Yao Source Type: research
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA
This study aimed to make an investigation into the role of NAT10-mediated ac4C modification in the malignant processes of LSCC cells. The NAT10 expression in LSCC tissues and cells was detected RT-qPCR and western blot. The ac4C dot blot was performed to detect ac4C level. Besides, the cell viability, migration, and invasion abilities were detected by CCK-8 and transwell assays. AcRIP-qPCR was performed to measure the abundance of ac4C on FOXM1 mRNA. RIP and Luciferase reporter assays were performed to demonstrate the interaction between NAT10 and FOXM1. Finally, the xenograft model was established to explore the role of N...
Source: Cancer Biology and Therapy - November 10, 2023 Category: Cancer & Oncology Authors: Zengpei Li Dajun Li Tianbin Yang Chen Yao Source Type: research
MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5
Cancer Biol Ther. 2023 Dec 31;24(1):2274122. doi: 10.1080/15384047.2023.2274122. Epub 2023 Nov 9.ABSTRACTDespite being the subject of multiple cancer studies, nothing is known about miR-597-5p's role in colitis-associated colorectal cancer (CAC). We intend to explore how miR-597-5p influences the growth and development of CAC. In order to construct a CAC model, mice were stimulated with azoxymethane (AOM)/dextran sulfate sodium (DSS). The in situ hybridization (ISH) and quantitative real-time polymerase chain reaction (qRT-PCR) was used for the detection of miR-597-5p expression. The protein expression of CXCL5 was determi...
Source: Cancer Biology and Therapy - November 9, 2023 Category: Cancer & Oncology Authors: Shuo Li Miao Yu Xiuying Wang Bingyuan Fei Source Type: research
MiR-597-5p inhibits carcinogenesis and macrophage recruitment in colitis-related colorectal cancer via reducing the expression of CXCL5
Cancer Biol Ther. 2023 Dec 31;24(1):2274122. doi: 10.1080/15384047.2023.2274122. Epub 2023 Nov 9.ABSTRACTDespite being the subject of multiple cancer studies, nothing is known about miR-597-5p's role in colitis-associated colorectal cancer (CAC). We intend to explore how miR-597-5p influences the growth and development of CAC. In order to construct a CAC model, mice were stimulated with azoxymethane (AOM)/dextran sulfate sodium (DSS). The in situ hybridization (ISH) and quantitative real-time polymerase chain reaction (qRT-PCR) was used for the detection of miR-597-5p expression. The protein expression of CXCL5 was determi...
Source: Cancer Biology and Therapy - November 9, 2023 Category: Cancer & Oncology Authors: Shuo Li Miao Yu Xiuying Wang Bingyuan Fei Source Type: research
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness
Cancer Biol Ther. 2023 Dec 31;24(1):2271638. doi: 10.1080/15384047.2023.2271638. Epub 2023 Nov 6.ABSTRACTThe poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic plasticity and cell fate. Following the loss of PCBP1 function, the FAM3C gene (encoding the Interleukin-like EMT inducer, or "ILEI" protein) and the leukemia inhibitory factor receptor (LIFR) gene are upregulated. Interaction between FAM3C and LIFR in the extracellular space induces phosphorylat...
Source: Cancer Biology and Therapy - November 6, 2023 Category: Cancer & Oncology Authors: William S Streitfeld Annamarie C Dalton Breege V Howley Philip H Howe Source Type: research
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness
Cancer Biol Ther. 2023 Dec 31;24(1):2271638. doi: 10.1080/15384047.2023.2271638. Epub 2023 Nov 6.ABSTRACTThe poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic plasticity and cell fate. Following the loss of PCBP1 function, the FAM3C gene (encoding the Interleukin-like EMT inducer, or "ILEI" protein) and the leukemia inhibitory factor receptor (LIFR) gene are upregulated. Interaction between FAM3C and LIFR in the extracellular space induces phosphorylat...
Source: Cancer Biology and Therapy - November 6, 2023 Category: Cancer & Oncology Authors: William S Streitfeld Annamarie C Dalton Breege V Howley Philip H Howe Source Type: research
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness
Cancer Biol Ther. 2023 Dec 31;24(1):2271638. doi: 10.1080/15384047.2023.2271638. Epub 2023 Nov 6.ABSTRACTThe poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic plasticity and cell fate. Following the loss of PCBP1 function, the FAM3C gene (encoding the Interleukin-like EMT inducer, or "ILEI" protein) and the leukemia inhibitory factor receptor (LIFR) gene are upregulated. Interaction between FAM3C and LIFR in the extracellular space induces phosphorylat...
Source: Cancer Biology and Therapy - November 6, 2023 Category: Cancer & Oncology Authors: William S Streitfeld Annamarie C Dalton Breege V Howley Philip H Howe Source Type: research
