A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis
CONCLUSION: MALAT1 downregulated DNMT1 by miR-137/BCL11A pathway to enhance TNBC stemness and tumorigenesis; meanwhile, DNMT1/MALAT1 formed a positive feedback loop to continuously promote TNBC malignant behaviors.PMID:37548553 | DOI:10.1080/15384047.2023.2235768 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - August 7, 2023 Category: Cancer & Oncology Authors: Yu Hu Yuqiong He Na Luo Xin Li Lei Guo Kejing Zhang Source Type: research
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Cancer Biol Ther. 2023 Dec 31;24(1):2198479. doi: 10.1080/15384047.2023.2198479.ABSTRACTDespite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remai...
Source: Cancer Biology and Therapy - August 1, 2023 Category: Cancer & Oncology Authors: Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese Source Type: research
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Cancer Biol Ther. 2023 Dec 31;24(1):2198479. doi: 10.1080/15384047.2023.2198479.ABSTRACTDespite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remai...
Source: Cancer Biology and Therapy - August 1, 2023 Category: Cancer & Oncology Authors: Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese Source Type: research
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Cancer Biol Ther. 2023 Dec 31;24(1):2198479. doi: 10.1080/15384047.2023.2198479.ABSTRACTDespite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remai...
Source: Cancer Biology and Therapy - August 1, 2023 Category: Cancer & Oncology Authors: Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese Source Type: research
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence
Cancer Biol Ther. 2023 Dec 31;24(1):2198479. doi: 10.1080/15384047.2023.2198479.ABSTRACTDespite recent advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year overall survival of only 10%. Since either at or within a few months of diagnosis, most patients with PDAC will present with metastatic disease, a more individualized approach to select patients who may benefit from more aggressive therapy has been suggested. Although studies have reported improved survival in PDAC and isolated pulmonary metastasis (ISP) compared to extrapulmonary metastases, such findings remai...
Source: Cancer Biology and Therapy - August 1, 2023 Category: Cancer & Oncology Authors: Orimisan Samuel Adekolujo Ahsan Wahab Maxwell Oluwole Akanbi Tolutope Oyasiji Borys Hrinczenko Olatunji Boladale Alese Source Type: research
