Statement of Retraction: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2240179. doi: 10.1080/15384047.2023.2240179.NO ABSTRACTPMID:37661634 | DOI:10.1080/15384047.2023.2240179 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 4, 2023 Category: Cancer & Oncology Source Type: research
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis
Cancer Biol Ther. 2023 Dec 31;24(1):2249170. doi: 10.1080/15384047.2023.2249170.ABSTRACTSinapine thiocyanate (ST), an alkaloid existed extensively in seeds of cruciferous plants, exhibits a number of pharmacological effects, including anti-inflammatory and anti-malignancy properties. However, it is still unknown what effects and molecular mechanisms ST has on colorectal cancer (CRC). In the current study, it was indicated that ST inhibited proliferation, colony formation, and apoptosis in vitro, as well as arrested the G1 phase of CRC cells. There was a significant repressive effects of ST on invasion and migration of CRC ...
Source: Cancer Biology and Therapy - August 30, 2023 Category: Cancer & Oncology Authors: Yan Yang Zhirui Zeng Lian Li Shan Lei Yingmin Wu Tengxiang Chen Jinjuan Zhang Source Type: research
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis
Cancer Biol Ther. 2023 Dec 31;24(1):2249170. doi: 10.1080/15384047.2023.2249170.ABSTRACTSinapine thiocyanate (ST), an alkaloid existed extensively in seeds of cruciferous plants, exhibits a number of pharmacological effects, including anti-inflammatory and anti-malignancy properties. However, it is still unknown what effects and molecular mechanisms ST has on colorectal cancer (CRC). In the current study, it was indicated that ST inhibited proliferation, colony formation, and apoptosis in vitro, as well as arrested the G1 phase of CRC cells. There was a significant repressive effects of ST on invasion and migration of CRC ...
Source: Cancer Biology and Therapy - August 30, 2023 Category: Cancer & Oncology Authors: Yan Yang Zhirui Zeng Lian Li Shan Lei Yingmin Wu Tengxiang Chen Jinjuan Zhang Source Type: research
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis
Cancer Biol Ther. 2023 Dec 31;24(1):2249170. doi: 10.1080/15384047.2023.2249170.ABSTRACTSinapine thiocyanate (ST), an alkaloid existed extensively in seeds of cruciferous plants, exhibits a number of pharmacological effects, including anti-inflammatory and anti-malignancy properties. However, it is still unknown what effects and molecular mechanisms ST has on colorectal cancer (CRC). In the current study, it was indicated that ST inhibited proliferation, colony formation, and apoptosis in vitro, as well as arrested the G1 phase of CRC cells. There was a significant repressive effects of ST on invasion and migration of CRC ...
Source: Cancer Biology and Therapy - August 30, 2023 Category: Cancer & Oncology Authors: Yan Yang Zhirui Zeng Lian Li Shan Lei Yingmin Wu Tengxiang Chen Jinjuan Zhang Source Type: research
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis
Cancer Biol Ther. 2023 Dec 31;24(1):2249170. doi: 10.1080/15384047.2023.2249170.ABSTRACTSinapine thiocyanate (ST), an alkaloid existed extensively in seeds of cruciferous plants, exhibits a number of pharmacological effects, including anti-inflammatory and anti-malignancy properties. However, it is still unknown what effects and molecular mechanisms ST has on colorectal cancer (CRC). In the current study, it was indicated that ST inhibited proliferation, colony formation, and apoptosis in vitro, as well as arrested the G1 phase of CRC cells. There was a significant repressive effects of ST on invasion and migration of CRC ...
Source: Cancer Biology and Therapy - August 30, 2023 Category: Cancer & Oncology Authors: Yan Yang Zhirui Zeng Lian Li Shan Lei Yingmin Wu Tengxiang Chen Jinjuan Zhang Source Type: research
RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27
In this study, we demonstrated that RBX1 silencing could inhibit MM cell growth and promote cell drug resistance. RBX1 directly interacted with and triggered the ubiquitination and degradation of p27, ultimately causing p27 reduction. Additionally, cell growth and apoptosis analysis indicated that the role of RBX1 in regulating myeloma cell proliferation and drug resistance resulted from p27 accumulation, which occurred in a Thr187 phosphorylation-dependent manner. Furthermore, the cell-cycle analysis demonstrated that RBX1 overexpression induced cells to enter the cell cycle (S-phase) and partially inhibited chemotherapeu...
Source: Cancer Biology and Therapy - August 28, 2023 Category: Cancer & Oncology Authors: Enfang Bao Yu Zhou Song He Jie Tang Yunhua He Mengyuan Zhu Chun Cheng Yuchan Wang Source Type: research
The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer
Cancer Biol Ther. 2023 Dec 31;24(1):2249174. doi: 10.1080/15384047.2023.2249174.ABSTRACTInfection with high-risk human papillomavirus (HPV), for example, with types 16 and 18, is closely associated with cervical cancer development, which continues to threaten women's health globally. Although HPV oncogenes have been recognized as the main cause of transformation of normal cervical epithelial cells, non-coding RNA could also be involved in the initiation and promotion of cervical cancer development. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented long non-coding RNA (lncRNA), has been prev...
Source: Cancer Biology and Therapy - August 28, 2023 Category: Cancer & Oncology Authors: Suzhen Wu Lili Liu Huanying Xu Qiaoling Zhu Minhua Tan Source Type: research
RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27
In this study, we demonstrated that RBX1 silencing could inhibit MM cell growth and promote cell drug resistance. RBX1 directly interacted with and triggered the ubiquitination and degradation of p27, ultimately causing p27 reduction. Additionally, cell growth and apoptosis analysis indicated that the role of RBX1 in regulating myeloma cell proliferation and drug resistance resulted from p27 accumulation, which occurred in a Thr187 phosphorylation-dependent manner. Furthermore, the cell-cycle analysis demonstrated that RBX1 overexpression induced cells to enter the cell cycle (S-phase) and partially inhibited chemotherapeu...
Source: Cancer Biology and Therapy - August 28, 2023 Category: Cancer & Oncology Authors: Enfang Bao Yu Zhou Song He Jie Tang Yunhua He Mengyuan Zhu Chun Cheng Yuchan Wang Source Type: research
The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer
Cancer Biol Ther. 2023 Dec 31;24(1):2249174. doi: 10.1080/15384047.2023.2249174.ABSTRACTInfection with high-risk human papillomavirus (HPV), for example, with types 16 and 18, is closely associated with cervical cancer development, which continues to threaten women's health globally. Although HPV oncogenes have been recognized as the main cause of transformation of normal cervical epithelial cells, non-coding RNA could also be involved in the initiation and promotion of cervical cancer development. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented long non-coding RNA (lncRNA), has been prev...
Source: Cancer Biology and Therapy - August 28, 2023 Category: Cancer & Oncology Authors: Suzhen Wu Lili Liu Huanying Xu Qiaoling Zhu Minhua Tan Source Type: research
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
In this study, we identified PIK3CA mutant (PIK3CA MT) as a determinant of resistance to SMI-4a, a highly selective PIM1 kinase inhibitor, in CRC cell lines. In CRC cell lines, SMI-4a showed its effect only in PIK3CA wild type (PIK3CA WT) cell lines, while PIK3CA MT cells did not respond to SMI-4a in cell death assays. In vivo xenograft and PDX experiments confirmed that PIK3CA MT is responsible for the resistance to SMI-4a. Inhibition of PIK3CA MT by PI3K inhibitors restored SMI-4a sensitivity in PIK3CA MT CRC cell lines. Taken together, these results demonstrate that sensitivity to SMI-4a is determined by the PIK3CA geno...
Source: Cancer Biology and Therapy - August 25, 2023 Category: Cancer & Oncology Authors: Yoon Sun Park Joseph Kim Yea Seong Ryu Jai-Hee Moon Yu Jin Shin Jeong Hee Kim Seung-Woo Hong Soo-A Jung Seul Lee Seung-Mi Kim Dae Hee Lee Do Yeon Kim Hyeseon Yun Ji-Eun You Dong Il Yoon Chul Hee Kim Dong-In Koh Dong-Hoon Jin Source Type: research
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
In this study, we identified PIK3CA mutant (PIK3CA MT) as a determinant of resistance to SMI-4a, a highly selective PIM1 kinase inhibitor, in CRC cell lines. In CRC cell lines, SMI-4a showed its effect only in PIK3CA wild type (PIK3CA WT) cell lines, while PIK3CA MT cells did not respond to SMI-4a in cell death assays. In vivo xenograft and PDX experiments confirmed that PIK3CA MT is responsible for the resistance to SMI-4a. Inhibition of PIK3CA MT by PI3K inhibitors restored SMI-4a sensitivity in PIK3CA MT CRC cell lines. Taken together, these results demonstrate that sensitivity to SMI-4a is determined by the PIK3CA geno...
Source: Cancer Biology and Therapy - August 25, 2023 Category: Cancer & Oncology Authors: Yoon Sun Park Joseph Kim Yea Seong Ryu Jai-Hee Moon Yu Jin Shin Jeong Hee Kim Seung-Woo Hong Soo-A Jung Seul Lee Seung-Mi Kim Dae Hee Lee Do Yeon Kim Hyeseon Yun Ji-Eun You Dong Il Yoon Chul Hee Kim Dong-In Koh Dong-Hoon Jin Source Type: research
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
In this study, we identified PIK3CA mutant (PIK3CA MT) as a determinant of resistance to SMI-4a, a highly selective PIM1 kinase inhibitor, in CRC cell lines. In CRC cell lines, SMI-4a showed its effect only in PIK3CA wild type (PIK3CA WT) cell lines, while PIK3CA MT cells did not respond to SMI-4a in cell death assays. In vivo xenograft and PDX experiments confirmed that PIK3CA MT is responsible for the resistance to SMI-4a. Inhibition of PIK3CA MT by PI3K inhibitors restored SMI-4a sensitivity in PIK3CA MT CRC cell lines. Taken together, these results demonstrate that sensitivity to SMI-4a is determined by the PIK3CA geno...
Source: Cancer Biology and Therapy - August 25, 2023 Category: Cancer & Oncology Authors: Yoon Sun Park Joseph Kim Yea Seong Ryu Jai-Hee Moon Yu Jin Shin Jeong Hee Kim Seung-Woo Hong Soo-A Jung Seul Lee Seung-Mi Kim Dae Hee Lee Do Yeon Kim Hyeseon Yun Ji-Eun You Dong Il Yoon Chul Hee Kim Dong-In Koh Dong-Hoon Jin Source Type: research
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer
In this study, we identified PIK3CA mutant (PIK3CA MT) as a determinant of resistance to SMI-4a, a highly selective PIM1 kinase inhibitor, in CRC cell lines. In CRC cell lines, SMI-4a showed its effect only in PIK3CA wild type (PIK3CA WT) cell lines, while PIK3CA MT cells did not respond to SMI-4a in cell death assays. In vivo xenograft and PDX experiments confirmed that PIK3CA MT is responsible for the resistance to SMI-4a. Inhibition of PIK3CA MT by PI3K inhibitors restored SMI-4a sensitivity in PIK3CA MT CRC cell lines. Taken together, these results demonstrate that sensitivity to SMI-4a is determined by the PIK3CA geno...
Source: Cancer Biology and Therapy - August 25, 2023 Category: Cancer & Oncology Authors: Yoon Sun Park Joseph Kim Yea Seong Ryu Jai-Hee Moon Yu Jin Shin Jeong Hee Kim Seung-Woo Hong Soo-A Jung Seul Lee Seung-Mi Kim Dae Hee Lee Do Yeon Kim Hyeseon Yun Ji-Eun You Dong Il Yoon Chul Hee Kim Dong-In Koh Dong-Hoon Jin Source Type: research
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression
Cancer Biol Ther. 2023 Dec 31;24(1):2246205. doi: 10.1080/15384047.2023.2246205.ABSTRACTCircRNAs have been proven to play a pivotal role in cancer progression. The present study aims to explore the roles and related mechanisms of circSETD2 in breast cancer proliferation, migration and invasion. The expression of circSETD2 in BC was assessed by the GEO database and qRT‒PCR. The biological function and underlying molecular mechanism of circSETD2 in BC were explored using in vitro and in vivo experiments, including CCK8, transwell, RIP, western blot, and xenograft mouse models. The expression of circSETD2 was downregulated ...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Lan Jing Liu Yang Cao Jianbo Wan Yuqiu Zhou Yehui Source Type: research
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2246206. doi: 10.1080/15384047.2023.2246206.ABSTRACTTranscription factor 3 (TCF3) is a member of the basic Helix - Loop - Helix (bHLH) transcription factor (TF) family and is encoded by the TCF3 gene (also known as E2A). It has been shown that TCF3 functions as a key transcription factor in the pathogenesis of several human cancers and plays an important role in stem cell maintenance and carcinogenesis. However, the effect of TCF3 in the progression of esophageal squamous cell carcinoma (ESCC) is poorly known. In our study, TCF3 was found to express highly and correlated with cancer stag...
Source: Cancer Biology and Therapy - August 22, 2023 Category: Cancer & Oncology Authors: Zhao-Xing Li Ming-Chuang Sun Kang Fang Zi-Ying Zhao Zhu-Yun Leng Ze-Hua Zhang Ai-Ping Xu Yuan Chu Li Zhang Jingjing Lian Tao Chen Mei-Dong Xu Source Type: research
