Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | PMC:PMC10978019 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer
CONCLUSION: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.PMID:38536706 | DOI:10.1080/15384047.2024.2331273 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Dongfang Chen Jianlin Xu Yizhuo Zhao Baohui Han Runbo Zhong Source Type: research
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma
Cancer Biol Ther. 2024 Dec 31;25(1):2333590. doi: 10.1080/15384047.2024.2333590. Epub 2024 Mar 26.ABSTRACTN6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differentia...
Source: Cancer Biology and Therapy - March 27, 2024 Category: Cancer & Oncology Authors: Yong Wang Lisha Peng Feng Wang Source Type: research
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2328382. doi: 10.1080/15384047.2024.2328382. Epub 2024 Mar 26.ABSTRACTNon-small cell lung cancer (NSCLC) is among the most difficult malignancies to treat. Type III collagen (COL3A1) can affect the progression and chemoresistance development of NSCLC. We herein explored the mechanism that drives COL3A1 dysregulation in NSCLC. Potential RNA-binding proteins (RBPs) and transcription factors (TFs) that could bind to COL3A1 were searched by bioinformatics. mRNA expression was detected by quantitative PCR. Protein expression was evaluated using immunoblotting and immunohistochemistry. The eff...
Source: Cancer Biology and Therapy - March 26, 2024 Category: Cancer & Oncology Authors: Jiankun Ren Songwei Zhao Junyu Lai Source Type: research
The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research
The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research
