The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
Cancer Biol Ther. 2024 Dec 31;25(1):2332000. doi: 10.1080/15384047.2024.2332000. Epub 2024 Mar 23.ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and despite the approved combination of BRAF and MEK1/2 inhibition for BRAF-mutant ATC, resistance often occurs. Here, we assess growth and signaling responses to combined BRAF and MEK1/2 inhibition in a panel of BRAF-mutant thyroid cancer cell lines. We first showed that combined BRAF a...
Source: Cancer Biology and Therapy - March 24, 2024 Category: Cancer & Oncology Authors: Hannah M Hicks Veronica L Nassar Jane Lund Madison M Rose Rebecca E Schweppe Source Type: research
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Cancer Biol Ther. 2024 Dec 31;25(1):2329372. doi: 10.1080/15384047.2024.2329372. Epub 2024 Mar 17.ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell viability. Seahorse was performed to evaluate the cell glycolysis. Luciferase assay was used to detect the transcriptional regulation. ChIP was performed to assess the binding between transcriptional factors with the promoters. Co-IP was used to assess the binding between proteins. ...
Source: Cancer Biology and Therapy - March 18, 2024 Category: Cancer & Oncology Authors: Shufeng Liu Xiaoguang Chen Liqi Zhang Bo Lu Source Type: research
Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research
Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research
Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes
Cancer Biol Ther. 2024 Dec 31;25(1):2329368. doi: 10.1080/15384047.2024.2329368. Epub 2024 Mar 14.ABSTRACTRedox adaptation causes poor prognosis by adapting cancer cells to excessive oxidative stress. Previously, we introduced an oxidative stress-resistant metastatic prostate cancer (mPC) model (LNCaP-HPR) that redox adaptation reduced the effect of Cabazitaxel (Cab), the last taxane-derivative for metastatic castration-resistant PC (mCRPC). Whereas, we investigated for the first time whether there is an association between the altered apoptotic effect and pro-oxidant efficacy of Cab on the redox adaptation in PC cells wit...
Source: Cancer Biology and Therapy - March 15, 2024 Category: Cancer & Oncology Authors: Isil Ezgi Eryilmaz Unal Egeli Gulsah Cecener Source Type: research
Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Cancer Biol Ther. 2024 Dec 31;25(1):2323765. doi: 10.1080/15384047.2024.2323765. Epub 2024 Mar 11.ABSTRACTAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to th...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Source Type: research
The relationship between long non-coding gene < em > CASC21 < /em > polymorphisms and cervical cancer
CONCLUSION: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.PMID:38465665 | PMC:PMC10936591 | DOI:10.1080/15384047.2024.2322207 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi Source Type: research
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer
Cancer Biol Ther. 2024 Dec 31;25(1):2325130. doi: 10.1080/15384047.2024.2325130. Epub 2024 Mar 11.ABSTRACTEmerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an essential fatty acid with the highest consumption in the Western diet regimen, has shown pro-tumorigenic or anti-tumorigenic effects on tumor cell growth and invasion in multiple types of cancer. However, the biological role of linoleic acid in endometrial cancer remains unclear. In the present study, we aimed to investigate...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Jianqing Qiu Ziyi Zhao Hongyan Suo Sarah E Paraghamian Gabrielle M Hawkins Wenchuan Sun Xin Zhang Tianran Hao Beor Deng Xiaochang Shen Chunxiao Zhou Victoria Bae-Jump Source Type: research
Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
Cancer Biol Ther. 2024 Dec 31;25(1):2323768. doi: 10.1080/15384047.2024.2323768. Epub 2024 Mar 11.ABSTRACTDouble minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression. After screening for SUMO-related molecule expression within various tumor sample and cell line databases, we found that SUMO-conjugating enzyme UBC9 has been associated with genome instability and tumor cell DM counts, which was confirmed both in vitro and in vivo. Karyotyping determined DM counts post-UBC9 knockdown or SUMOylatio...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Yusi Wang Hongyan Zou Wei Ji Min Huang Benhui You Nan Sun Yuandong Qiao Peng Liu Lidan Xu Xuelong Zhang Mengdi Cai Ye Kuang Songbin Fu Wenjing Sun Xueyuan Jia Jie Wu Source Type: research
Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Cancer Biol Ther. 2024 Dec 31;25(1):2323765. doi: 10.1080/15384047.2024.2323765. Epub 2024 Mar 11.ABSTRACTAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to th...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Source Type: research
The relationship between long non-coding gene < em > CASC21 < /em > polymorphisms and cervical cancer
CONCLUSION: Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.PMID:38465665 | PMC:PMC10936591 | DOI:10.1080/15384047.2024.2322207 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi Source Type: research
