< em > Ruangan Lidan decoction < /em > inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4
Cancer Biol Ther. 2023 Dec 31;24(1):2246198. doi: 10.1080/15384047.2023.2246198. Epub 2023 Sep 29.ABSTRACTA growing number of studies have suggested that traditional Chinese medicine (TCM) plays an essential role in the development and occurrence of liver cancer. However, the function of Ruangan Lidan decoction (RLD) in liver cancer are not yet adequately identified and manifested, which attracted our attention. The key genes related to liver cancer and RLD and the upstream miRNAs of PDK4 were obtained based on bioinformatics analysis, followed by verification of the targeting relationship between miR-9-5p and PDK4. Next, ...
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Tao Si Liyin Huang Ting Liang Ping Huang Hongyu Zhang Mingmin Zhang Xiaoling Zhou Source Type: research
Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1
In conclusion, this study reveals that hsa_circ_0119412 knockdown attenuates the progression of HCC by targeting miR-526b-5p/STMN1 axis.PMID:37773733 | DOI:10.1080/15384047.2023.2256951 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Song Wu Tao Tang Hongchi Zhou Jing Huang Xiaoliang Kang Junli Zhang Source Type: research
< em > Ruangan Lidan decoction < /em > inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4
Cancer Biol Ther. 2023 Dec 31;24(1):2246198. doi: 10.1080/15384047.2023.2246198. Epub 2023 Sep 29.ABSTRACTA growing number of studies have suggested that traditional Chinese medicine (TCM) plays an essential role in the development and occurrence of liver cancer. However, the function of Ruangan Lidan decoction (RLD) in liver cancer are not yet adequately identified and manifested, which attracted our attention. The key genes related to liver cancer and RLD and the upstream miRNAs of PDK4 were obtained based on bioinformatics analysis, followed by verification of the targeting relationship between miR-9-5p and PDK4. Next, ...
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Tao Si Liyin Huang Ting Liang Ping Huang Hongyu Zhang Mingmin Zhang Xiaoling Zhou Source Type: research
Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1
In conclusion, this study reveals that hsa_circ_0119412 knockdown attenuates the progression of HCC by targeting miR-526b-5p/STMN1 axis.PMID:37773733 | DOI:10.1080/15384047.2023.2256951 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Song Wu Tao Tang Hongchi Zhou Jing Huang Xiaoliang Kang Junli Zhang Source Type: research
< em > Ruangan Lidan decoction < /em > inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4
Cancer Biol Ther. 2023 Dec 31;24(1):2246198. doi: 10.1080/15384047.2023.2246198. Epub 2023 Sep 29.ABSTRACTA growing number of studies have suggested that traditional Chinese medicine (TCM) plays an essential role in the development and occurrence of liver cancer. However, the function of Ruangan Lidan decoction (RLD) in liver cancer are not yet adequately identified and manifested, which attracted our attention. The key genes related to liver cancer and RLD and the upstream miRNAs of PDK4 were obtained based on bioinformatics analysis, followed by verification of the targeting relationship between miR-9-5p and PDK4. Next, ...
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Tao Si Liyin Huang Ting Liang Ping Huang Hongyu Zhang Mingmin Zhang Xiaoling Zhou Source Type: research
Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1
In conclusion, this study reveals that hsa_circ_0119412 knockdown attenuates the progression of HCC by targeting miR-526b-5p/STMN1 axis.PMID:37773733 | DOI:10.1080/15384047.2023.2256951 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 29, 2023 Category: Cancer & Oncology Authors: Song Wu Tao Tang Hongchi Zhou Jing Huang Xiaoliang Kang Junli Zhang Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | PMC:PMC10512822 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Role of human epidermal growth factor receptor 3 in treatment resistance of anaplastic lymphoma kinase translocated non-small cell lung cancer
CONCLUSIONS: This study provides evidence that HER3 may mediate TKI resistance in ALK+ NSCLC. Interestingly, we were able to show that both translocated ALK and HER3 could interact. Joint targeting of ALK and HER3 could be further investigate in ALK+ NSCLC.PMID:37722715 | DOI:10.1080/15384047.2023.2256906 (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - September 18, 2023 Category: Cancer & Oncology Authors: Tiia J Honkanen Milla E K Luukkainen Jussi P Koivunen Source Type: research
Drug repurposing based on differentially expressed genes suggests drug combinations with possible synergistic effects in treatment of lung adenocarcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2253586. doi: 10.1080/15384047.2023.2253586.ABSTRACTLung adenocarcinoma is one of the leading causes of cancer-related mortality globally. Various treatment approaches and drugs had little influence on overall survival; thus, new drugs and treatment strategies are needed. Drug repositioning (repurposing) seems a favorable approach considering that developing new drugs needs much more time and costs. We performed a meta-analysis on 6 microarray datasets to obtain the main genes with significantly altered expression in lung adenocarcinoma. Following that, we found major gene clusters and h...
Source: Cancer Biology and Therapy - September 15, 2023 Category: Cancer & Oncology Authors: Liora Yesharim Shahram Teimourian Source Type: research
