SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis

CONCLUSIONS: In conclusion, SIRT1 can function as an oncogene in CRC by accelerating the growth, metastasis and chemoresistance to 5-FU of CRC cells through the p53/miR-101/KPNA3 axis.PMID:37575080 | PMC:PMC10431729 | DOI:10.1080/15384047.2023.2235770

Source: Cancer Biology and Therapy - August 14, 2023 Category: Cancer & Oncology Authors: Xiao-Wei Wang Ying-Hao Jiang Wei Ye Chun-Fa Shao Jian-Jin Xie Xia Li Source Type: research