Epigenetic regulation of breast cancer metastasis
AbstractBreast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women worldwide. Recurrent metastasis is associated with poor patient outcomes and poses a significant challenge in breast cancer therapies. Cancer cells adapting to a new tissue microenvironment is the key event in distant metastasis development, where the disseminating tumor cells are likely to acquire genetic and epigenetic alterations during the process of metastatic colonization. Despite several decades of research in this field, the exact mechanisms governing metastasis are not fully unders...
Source: Cancer and Metastasis Reviews - October 19, 2023 Category: Cancer & Oncology Source Type: research
Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications
AbstractExtracellular vesicles (EVs) are small lipid bilayer –enclosed vesicles that mediate vital cellular communication by transferring cargo between cells. Among these, tissue-derived extracellular vesicles (Ti-EVs) stand out due to their origin from the tissue microenvironment, providing a more accurate reflection of changes in this setting. This unique advantage makes Ti-EVs valuable in investigating the intricate relationship between extracellular vesicles and cancer progression. Despite considerable research efforts exploring the association between Ti-EVs and cancers, a comprehensive clustering or grouping of the...
Source: Cancer and Metastasis Reviews - October 18, 2023 Category: Cancer & Oncology Source Type: research
Preface
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - October 6, 2023 Category: Cancer & Oncology Source Type: research
Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?
AbstractCellular plasticity can occur naturally in an organism and is considered an adapting mechanism during the developmental stage. However, abnormal cellular plasticity is observed in different diseased conditions, including cancer. Cancer cell plasticity triggers the stimuli of epithelial-mesenchymal transition (EMT), abnormal epigenetic changes, expression of stem cell factors and implicated signaling pathways, etc., and helps in the maintenance of CSC phenotype. Conversely, CSC maintains the cancer cell plasticity, EMT, and epigenetic plasticity. EMT contributes to increased cell migration and greater diversity with...
Source: Cancer and Metastasis Reviews - October 5, 2023 Category: Cancer & Oncology Source Type: research
Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
AbstractCancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and is implicated in the multiple cancer defense mechanisms associated with therapy resistance and therapy evasion. Cancer resistance represents one of the significant obstacles in the clinical management of cancer. Some reversal chemosensitizing agents have been developed to resolve this serious clinical problem, but they have not yet been proven applicable in oncological practice. Activated nuclear factor kappa B (NF- κB) is a frequently observed biomarker in chemoresistant breast cancer (BC). Therefore, it denotes an at...
Source: Cancer and Metastasis Reviews - October 4, 2023 Category: Cancer & Oncology Source Type: research
Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
AbstractTumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target genes and dysregulated pathways in tumor invasion and migration. Therefore, targeting HIF-1 pathway and cross-talked mediators seems to be a novel strategy in cancer prevention and treatment. In recent decades, tremendous efforts have been made to develop multi-targeted therapies to modulate several dysregulated pathways in cancer angiogenesis, invasion, and metast...
Source: Cancer and Metastasis Reviews - October 4, 2023 Category: Cancer & Oncology Source Type: research
Sam68 is a druggable vulnerability point in cancer stem cells
AbstractSam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characterized in numerous cellular functions, such as RNA processing, cell cycle regulation, kinase- and growth factor signaling. Recent investigations highlighted Sam68 as a primary target of a class of reverse-turn peptidomimetic dru gs, initially developed as inhibitors of Wnt/β-catenin mediated transcription. Further investigations on such compounds revealed their capacity to selectively eliminate cancer stem cell (CSC) activity upon engaging Sam68. This work highlighted previously unappreciated roles for Sa...
Source: Cancer and Metastasis Reviews - October 4, 2023 Category: Cancer & Oncology Source Type: research
Epithelial-to-mesenchymal transition in cancer progression: unraveling the immunosuppressive module driving therapy resistance
This article discusses the role of EMT in promoting immune evasion and therapy resistance. We also discuss the ongoing research on developing therapeutic approaches targeting intrinsic and induced cell plasticity within the immune suppressive microenvironme nt. We believe this review article will update the current research status and equip researchers, clinicians, and other healthcare professionals with valuable insights enhancing their existing knowledge and shedding light on promising directions for future cancer research. This will facilitate the d evelopment of innovative strategies for managing therapy-resistant canc...
Source: Cancer and Metastasis Reviews - September 30, 2023 Category: Cancer & Oncology Source Type: research
B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
In this study, we explore the role of B7-H3 in tumor plasticity, emphasizing tumor glucose metabolism, angiogenesis, epithelial-mesenchymal transition, cancer stem cells, apoptosis, and changing immune signatures in the tumor immune landscape. We discuss how B7-H3-induced tumor plasticity contributes to immune evasion, metastasis, and therapy resistance. Furthermore, we delve into the most recent advancements in targeting B7-H3-based tumor immunotherapy as a potential approach to CRC treatment. (Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - September 28, 2023 Category: Cancer & Oncology Source Type: research
Metastasis suppressor genes in clinical practice: are they druggable?
AbstractSince the identification ofNM23 (now calledNME1) as the first metastasis suppressor gene (MSG), a small number of other gene products and non-coding RNAs have been identified that suppress specific parameters of the metastatic cascade, yet which have little or no ability to regulate primary tumor initiation or maintenance. MSG can regulate various pathways or cell biological functions such as those controlling mitogen-activated protein kinase pathway mediators, cell –cell and cell-extracellular matrix protein adhesion, cytoskeletal architecture, G-protein-coupled receptors, apoptosis, and transcriptional complexe...
Source: Cancer and Metastasis Reviews - September 25, 2023 Category: Cancer & Oncology Source Type: research
Next-generation immune checkpoint inhibitors as promising functional molecules in cancer therapeutics
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - September 20, 2023 Category: Cancer & Oncology Source Type: research
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
AbstractResistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially the genetic mutation behind the therapeutic resistance. However, non-mutational mechanisms, such as epigenetic modifications, and TME alteration, which is mainly driven by cancer cell plasticity, are also involved in therapeutic resistance. The concept of plasticity mainly relies on the conversion of non-cancer stem cells (CSCs) to CSCs or epithelial-to-mesenchymal transition via different mechanisms and various signaling pathways. Cancer plasticity plays a crucial role ...
Source: Cancer and Metastasis Reviews - September 14, 2023 Category: Cancer & Oncology Source Type: research
Epigenetic control of pancreatic cancer metastasis
AbstractSurgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). However, this treatment option is only feasible for a fraction of patients, as more than 50% of cases are diagnosed with metastasis. The multifaceted process of metastasis is still not fully understood, but recent data suggest that transcriptional and epigenetic plasticity play significant roles. Interfering with epigenetic reprogramming can potentially control the adaptive processes responsible for metastatic progression and therapy resistance, the...
Source: Cancer and Metastasis Reviews - September 2, 2023 Category: Cancer & Oncology Source Type: research
Biographies
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - September 1, 2023 Category: Cancer & Oncology Source Type: research
New progress of tuberculosis scar carcinoma
AbstractIt has been demonstrated that scar tissue and fibrosis may increase the likelihood of developing malignancies. Specifically, scar tissue has been linked to the occurrence and progression of lung cancer (LC), though the precise mechanisms necessitate further research for explanation. Lung scarring can stem from various causes, with carcinogenesis on scarring lesions in pulmonary tuberculosis (PTB) being the most frequent (accounting for approximately 75% of cases). Notably, having previously cured, PTB is the second most common risk factor for LC after smoking, with approximately 3% of PTB patients experiencing LC a...
Source: Cancer and Metastasis Reviews - August 16, 2023 Category: Cancer & Oncology Source Type: research
