Correction to: Adipocytokines and disease progression in endometrial cancer: a systematic review
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - January 27, 2022 Category: Cancer & Oncology Source Type: research
Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX
AbstractCancer metabolic heterogeneity develops in response to both intrinsic factors (mutations leading to activation of oncogenic pathways) and extrinsic factors (physiological and molecular signals from the extracellular milieu). Here we review causes and consequences of metabolic alterations in cancer cells with focus on hypoxia and acidosis, and with particular attention to carbonic anhydrase IX (CA IX). CA IX is a cancer-associated enzyme induced and activated by hypoxia in a broad range of tumor types, where it participates in pH regulation as well as in molecular mechanisms supporting cancer cells ’ invasion and ...
Source: Cancer and Metastasis Reviews - January 26, 2022 Category: Cancer & Oncology Source Type: research
The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues
AbstractDespite advancements in cancer management, tumor relapse and metastasis are associated with poor outcomes in many cancers. Over the past decade, oncogene-driven carcinogenesis, dysregulated cellular signaling networks, dynamic changes in the tissue microenvironment, epithelial-mesenchymal transitions, protein expression within regulatory pathways, and their part in tumor progression are described in several studies. However, the complexity of metabolic enzyme expression is considerably under evaluated. Alterations in cellular metabolism determine the individual phenotype and behavior of cells, which is a well-recog...
Source: Cancer and Metastasis Reviews - January 14, 2022 Category: Cancer & Oncology Source Type: research
Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective
AbstractWe have established considerable expertise in studying the role of platelets in cancer biology. From this expertise, we were keen to recognize the numerous venous-, arterial-, microvascular-, and macrovascular thrombotic events and immunologic disorders are caused by severe, acute-respiratory-syndrome coronavirus 2 (SARS-CoV-2) infections. With this offering, we explore the evolutionary connections that place platelets at the center of hemostasis, immunity, and adaptive phylogeny. Coevolutionary changes have also occurred in vertebrate viruses and their vertebrate hosts that reflect their respective evolutionary in...
Source: Cancer and Metastasis Reviews - January 12, 2022 Category: Cancer & Oncology Source Type: research
Emerging roles of epithelial-mesenchymal plasticity in invasion-metastasis cascade and therapy resistance
AbstractStrong association of cancer incidence and its progression with mortality highlights the need to decipher the cellular and molecular mechanisms that drive tumor cells to rapidly progress to metastatic disease and therapy resistance. Epithelial-mesenchymal plasticity (EMP) emerged as a key regulator of metastatic outgrowth. It allows neoplastic epithelial cells to delaminate from their neighbors either individually or collectively, traverse the extracellular matrix (ECM) barrier, enter into the circulation, and establish distal metastases. Plasticity between epithelial and mesenchymal states and the existence of hyb...
Source: Cancer and Metastasis Reviews - January 3, 2022 Category: Cancer & Oncology Source Type: research
Glycosylation as a regulator of site-specific metastasis
AbstractMetastasis is considered to be responsible for 90% of cancer-related deaths. Although it is clinically evident that metastatic patterns vary by primary tumor type, the molecular mechanisms underlying the site-specific nature of metastasis are an area of active investigation. One mechanism that has emerged as an important player in this process is glycosylation, or the addition of sugar moieties onto protein and lipid substrates. Glycosylation is the most common post-translational modification, occurring on more than 50% of translated proteins. Many of those proteins are either secreted or expressed on the cell memb...
Source: Cancer and Metastasis Reviews - December 30, 2021 Category: Cancer & Oncology Source Type: research
The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer
AbstractBreast cancer, the most frequent cancer in women, is characterized by pathological changes to the microbiome of breast tissue, the tumor, the gut, and the urinary tract. Changes to the microbiome are determined by the stage, grade, origin (NST/lobular), and receptor status of the tumor. This year is the 50th anniversary of when Hill and colleagues first showed that changes to the gut microbiome can support breast cancer growth, namely that the oncobiome can reactivate excreted estrogens. The currently available human and murine data suggest that oncobiosis is not a cause of breast cancer, but can support its growth...
Source: Cancer and Metastasis Reviews - December 30, 2021 Category: Cancer & Oncology Source Type: research
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
AbstractBranched-chain amino acids (BCAA) are essential amino acids utilized in anabolic and catabolic metabolism. While extensively studied in obesity and diabetes, recent evidence suggests an important role for BCAA metabolism in cancer. Elevated plasma levels of BCAA are associated with an increased risk of developing pancreatic cancer, namely pancreatic ductal adenocarcinoma (PDAC), a tumor with one of the highest 1-year mortality rates. The dreadful prognosis for PDAC patients could be attributable also to the early and frequent development of cancer cachexia, a fatal host metabolic reprogramming leading to muscle and...
Source: Cancer and Metastasis Reviews - December 28, 2021 Category: Cancer & Oncology Source Type: research
A multidisciplinary perspective on the complex interactions between sleep, circadian, and metabolic disruption in cancer patients
AbstractSleep is a basic need that is frequently set aside in modern societies. This leads to profound but complex physiological maladaptations in the body commonly referred to as circadian disruption, which recently has been characterized as a carcinogenic factor and reason for poor treatment outcomes, shortened survival, and reduced quality of life in cancer patients. As sleep and circadian physiology in cancer patients spans several disciplines including nursing science, neurology, oncology, molecular biology and medical technology, there is a lack of comprehensive and integrated approaches to deal with this serious and...
Source: Cancer and Metastasis Reviews - December 27, 2021 Category: Cancer & Oncology Source Type: research
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations
AbstractSmall cell lung carcinoma (SCLC) is characterized by high metastatic rate and poor prognosis. The platinum-based chemotherapy still represents the backbone of the therapy; however, acquired resistance develops almost in all patients. Although SCLC has been formerly considered a homogeneous disease, recent advances in SCLC research have highlighted the importance of inter- and intratumoral heterogeneity and have resulted in the subclassification of SCLC. The newly described SCLC subtypes are characterized by distinct biological behavior and vulnerabilities that can be therapeutically exploited. The PI3K/Akt/mTOR pat...
Source: Cancer and Metastasis Reviews - December 27, 2021 Category: Cancer & Oncology Source Type: research
The role of the metabolite cargo of extracellular vesicles in tumor progression
AbstractMetabolomic reprogramming in tumor and stroma cells is a hallmark of cancer but understanding its effects on the metabolite composition and function of tumor-derived extracellular vesicles (EVs) is still in its infancy. EVs are membrane-bound sacs with a complex molecular composition secreted by all living cells. They are key mediators of intercellular communication both in normal and pathological conditions and play a crucial role in tumor development. Although lipids are major components of EVs, most of the EV cargo studies have targeted proteins and nucleic acids. The potential of the EV metabolome as a source f...
Source: Cancer and Metastasis Reviews - December 27, 2021 Category: Cancer & Oncology Source Type: research
Model systems in SDHx-related pheochromocytoma/paraganglioma
AbstractPheochromocytoma (PHEO) and paraganglioma (PGL) (together PPGL) are tumors with poor outcomes that arise from neuroendocrine cells in the adrenal gland, and sympathetic and parasympathetic ganglia outside the adrenal gland, respectively. Many follow germline mutations in genes coding for subunits of succinate dehydrogenase (SDH), a tetrameric enzyme in the tricarboxylic acid (TCA) cycle that both converts succinate to fumarate and participates in electron transport. GermlineSDH subunitB (SDHB) mutations have a high metastatic potential. Herein, we review the spectrum of model organisms that have contributed hugely ...
Source: Cancer and Metastasis Reviews - December 27, 2021 Category: Cancer & Oncology Source Type: research
Adipocytokines and disease progression in endometrial cancer: a systematic review
The objective of the study was to document the effect of adipocytokines on endometrial cancer progression. A search of the databases CINAHL, Medline, PubMed, Cochrane, Web of Science, Embase and Google Scholar was performed for English language articles from January 2000 to December 2020 using the keywords: (Endometrial cancer) AND (progression OR metastasis) AND (adipocytokine OR adiponectin OR leptin OR visfatin OR IL-6 OR TNF- α OR adipokine OR cytokine). Forty-nine studies on adipocytokines have been included in this review. Adiponectin has been linked with anti-proliferative and anti-metastatic effects on endometrial...
Source: Cancer and Metastasis Reviews - December 24, 2021 Category: Cancer & Oncology Source Type: research
Extracellular citrate and metabolic adaptations of cancer cells
AbstractIt is well established that cancer cells acquire energy via the Warburg effect and oxidative phosphorylation. Citrate is considered to play a crucial role in cancer metabolism by virtue of its production in the reverse Krebs cycle from glutamine. Here, we review the evidence that extracellular citrate is one of the key metabolites of the metabolic pathways present in cancer cells. We review the different mechanisms by which pathways involved in keeping redox balance respond to the need of intracellular citrate synthesis under different extracellular metabolic conditions. In this context, we further discuss the hypo...
Source: Cancer and Metastasis Reviews - December 21, 2021 Category: Cancer & Oncology Source Type: research
Tumor metabolism: metabolic alterations and heterogeneity in cancer progression
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - December 16, 2021 Category: Cancer & Oncology Source Type: research
