The obesity-breast cancer link: a multidisciplinary perspective
AbstractObesity, exceptionally prevalent in the USA, promotes the incidence and progression of numerous cancer types including breast cancer. Complex, interacting metabolic and immune dysregulation marks the development of both breast cancer and obesity. Obesity promotes chronic low-grade inflammation, particularly in white adipose tissue, which drives immune dysfunction marked by increased pro-inflammatory cytokine production, alternative macrophage activation, and reduced T cell function. Breast tissue is predominantly composed of white adipose, and developing breast cancer readily and directly interacts with cells and s...
Source: Cancer and Metastasis Reviews - June 25, 2022 Category: Cancer & Oncology Source Type: research
Preface
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 20, 2022 Category: Cancer & Oncology Source Type: research
The role of bone marrow adipocytes in cancer progression: the impact of obesity
AbstractBone marrow adipose tissues (BMATs) and their main cellular component, bone marrow adipocytes (BMAds), are found within the bone marrow (BM), which is a niche for the development of hematological malignancies as well as bone metastasis from solid tumors such as breast and prostate cancers. In humans, BMAds are present within the hematopoietic or “red” BMAT and in the “yellow” BMAT where they are more densely packed. BMAds are emerging as new actors in tumor progression; however, there are many outstanding questions regarding their precise role. In this review, we summarized our current knowledge regarding t...
Source: Cancer and Metastasis Reviews - June 16, 2022 Category: Cancer & Oncology Source Type: research
Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective
AbstractEpigenetic regulation of gene expression is a fundamental determinant of molecular and cellular function, and epigenetic reprogramming in the context of cancer has emerged as one of the key enabling characteristics associated with acquisition of the core hallmarks of this disease. As such, there has been renewed interest in studying the role of transcription factors as epigenetic regulators of gene expression in cancer. In this review, we discuss the current state of knowledge surrounding the oncogenic functions of FOXC2, a transcription factor that frequently becomes dysregulated in a variety of cancer types. In a...
Source: Cancer and Metastasis Reviews - June 14, 2022 Category: Cancer & Oncology Source Type: research
Targeting lipid metabolism in cancer: neuroblastoma
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 10, 2022 Category: Cancer & Oncology Source Type: research
Biographies
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2022 Category: Cancer & Oncology Source Type: research
Notch signaling in malignant gliomas: supporting tumor growth and the vascular environment
Abstract
Glioblastoma is the most malignant form of glioma, which is the most commonly occurring tumor of the central nervous system. Notch signaling in glioblastoma is considered to be a marker of an undifferentiated tumor cell state, associated with tumor stem cells. Notch is also known for facilitating tumor dormancy escape, recurrence and progression after treatment. Studiesin vitro suggest that reducing, removing or blocking the expression of this gene triggers tumor cell differentiation, which shifts the phenotype away from stemness status and consequently facilitates treatment. In contrast, in the vasculature, No...
Source: Cancer and Metastasis Reviews - May 27, 2022 Category: Cancer & Oncology Source Type: research
De- “bug”-ing the microbiome in lung cancer
AbstractThe identification of microbes enriched in the healthy lung has led to the compelling discovery that microbes may contribute to lung cancer pathogenesis. Here, we review the recent literature showing microbial associations with lung cancer as well as the functional features that have been identified in human and murine studies. Most biomarker data remain limited due to variable findings. However, multiple studies have found that lung tumors or ipsilateral airway samples have decreased α diversity compared to normal tissue. Specific genera, such asVeillonella andStreptococcus, were also found in association with lu...
Source: Cancer and Metastasis Reviews - May 19, 2022 Category: Cancer & Oncology Source Type: research
