Correction to: Connecting the human microbiome and pancreatic cancer
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - May 10, 2022 Category: Cancer & Oncology Source Type: research
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
AbstractEsophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvir...
Source: Cancer and Metastasis Reviews - May 5, 2022 Category: Cancer & Oncology Source Type: research
Microbes and cancer: disease drivers, passengers, biomarkers, or therapeutics?
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - May 4, 2022 Category: Cancer & Oncology Source Type: research
Oncobiology and treatment of breast cancer in young women
AbstractFemale breast cancer emerged as the leading cancer type in terms of incidence globally in 2020. Although mortality due to breast cancer has improved during the past three decades in many countries, this trend has reversed in women less than 40 years since the past decade. From the biological standpoint, there is consensus among experts regarding the clinically relevant definition of breast cancer in young women (BCYW), with an age cut-off of 40 years. The idea that breast cancer is an aging disease has apparently broken in the case of BCYW due to the young onset and an overall poor outcome of BCYW patients. In g...
Source: Cancer and Metastasis Reviews - April 30, 2022 Category: Cancer & Oncology Source Type: research
Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation
AbstractMicrobiota are essential to normal immune development and there is growing recognition of its importance to human health and disease and deepening understanding of the complexity of host-microbe interactions in the human gut and other tissues. Commensal microbes not only can influence host immunity locally through impacts of bioactive microbial metabolites and direct interactions with epithelial cells and innate immune receptors but also can exert systemic immunomodulatory effects via impacts on host immune cells capable of trafficking beyond the gut. Emerging data suggest microbiota influence the development of mu...
Source: Cancer and Metastasis Reviews - April 29, 2022 Category: Cancer & Oncology Source Type: research
The cure from within? a review of the microbiome and diet in melanoma
AbstractTherapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thought impossible, cures for metastatic melanoma with immune checkpoint inhibitors have been developed within the last decade and now occur regularly in the clinic. Unfortunately, half of tumors do not respond to checkpoint inhibitors and efforts to further exploit the immune system are needed. Tantalizing associations with immune health and gut microbiome composition suggest we can improve the success rate of immunotherapy. The gut contains over half of the immune cells in our bodies and increasing...
Source: Cancer and Metastasis Reviews - April 27, 2022 Category: Cancer & Oncology Source Type: research
The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
AbstractInositol is an essential nutrient, obtained either by uptake from the environment or byde novo synthesis from glucose. Inositol and its derivatives exhibit tumor-suppressive effects, potentially mediated by inhibition of the ERK-MAPK or PI3K-Akt pathways. Accordingly, many cancers have been documented to silence expression of theISYNA1 gene, which encodes the rate-limiting enzyme of inositol synthesis. Paradoxically, recent studies have also reported upregulation ofISYNA1 in some cancers. Upregulation may reflect a compensatory response brought about by defective inositol uptake or oncogenic mutations that preclude...
Source: Cancer and Metastasis Reviews - April 25, 2022 Category: Cancer & Oncology Source Type: research
