Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment
AbstractGangliosides are sialylated glycolipids, mainly present at the cell surface membrane, involved in a variety of cellular signaling events. During malignant transformation, the composition of these glycosphingolipids is altered, leading to structural and functional changes, which are often negatively correlated to patient survival. Cancer cells have the ability to shed gangliosides into the tumor microenvironment, where they have a strong impact on anti-tumor immunity and promote tumor progression. Since most ganglioside species show prominent immunosuppressive activities, they might be considered checkpoint molecule...
Source: Cancer and Metastasis Reviews - June 2, 2023 Category: Cancer & Oncology Source Type: research
Colorectal cancer liver metastasis: genomic evolution and crosstalk with the liver microenvironment
AbstractColorectal cancer (CRC) patients frequently develop liver metastases, which are the major cause of cancer-related mortality. The molecular basis and management of colorectal liver metastases (CRLMs) remain a challenging clinical issue. Recent genomic evidence has demonstrated the liver tropism of CRC and the presence of a stricter evolutionary bottleneck in the liver as a target organ compared to lymph nodes. This bottleneck challenging CRC cells in the liver is organ-specific and requires adaptation not only at the genetic level, but also at the phenotypic level to crosstalk with the hepatic microenvironment. Here...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Pancreatic cancer epigenetics: adaptive metabolism reprograms starving primary tumors for widespread metastatic outgrowth
AbstractPancreatic cancer is a paradigm for adaptation to extreme stress. That is because genetic drivers are selected during tissue injury with epigenetic imprints encoding wound healing responses. Ironically, epigenetic memories of trauma that facilitate neoplasia can also recreate past stresses to restrain malignant progression through symbiotic tumor:stroma crosstalk. This is best exemplified by positive feedback between neoplastic chromatin outputs and fibroinflammatory stromal cues that encase malignant glands within a nutrient-deprived desmoplastic stroma. Because epigenetic imprints are chemically encoded by nutrie...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
The tumor-nerve circuit in breast cancer
In conclusion, the further research in breast cancer and its interactions with innervated neurons or neurotransmitters is promising in the clinical management of breast cancer. (Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Epigenetic markers and therapeutic targets for metastasis
AbstractThe last few years have seen an increasing number of discoveries which collectively demonstrate that histone and DNA modifying enzyme modulate different stages of metastasis. Moreover, epigenomic alterations can now be measured at multiple scales of analysis and are detectable in human tumors or liquid biopsies. Malignant cell clones with a proclivity for relapse in certain organs may arise in the primary tumor as a consequence of epigenomic alterations which cause a loss in lineage integrity. These alterations may occur due to genetic aberrations acquired during tumor progression or concomitant to therapeutic resp...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Oncogenic signaling-mediated regulation of chromatin during tumorigenesis
AbstractSignaling pathways play critical roles in executing and controlling important biological processes within cells. Cells/organisms trigger appropriate signal transduction pathways in order to turn on or off intracellular gene expression in response to environmental stimuli. An orchestrated regulation of different signaling pathways across different organs and tissues is the basis of many important biological functions. Presumably, any malfunctions or dysregulation of these signaling pathways contribute to the pathogenesis of disease, particularly cancer. In this review, we discuss how the dysregulation of signaling p...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Combination of immune-checkpoint inhibitors and targeted therapies for melanoma therapy: The more, the better?
AbstractThe approval of immune-checkpoint inhibitors (CPI) and mitogen activated protein kinase inhibitors (MAPKi) in recent years significantly improved the treatment management and survival of patients with advanced malignant melanoma. CPI aim to counter-act receptor-mediated inhibitory effects of tumor cells and immunomodulatory cell types on effector T cells, whereas MAPKi are intended to inhibit tumor cell survival. In agreement with these complementary modes of action preclinical data indicated that the combined application of CPI and MAPKi or their optimal sequencing might provide additional clinical benefit. In thi...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Epigenetic changes and the dynamic heterogeneity of the metastatic phenotype – challenges ahead
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Biographies
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Kenneth V. Honn, Ph.D. (1946 –2023)
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Biographies
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Metabolic factors associated with the prognosis of oligometastatic patients treated with stereotactic body radiotherapy
AbstractOver the past two decades, it has been established that cancer patients with oligometastases, i.e., only a few detectable metastases confined to one or a few organs, may benefit from an aggressive local treatment approach such as the application of high-precision stereotactic body radiotherapy (SBRT). Specifically, some studies have indicated that achieving long-term local tumor control of oligometastases is associated with prolonged overall survival. This motivates investigations into which factors may modify the dose-response relationship of SBRT by making metastases more or less radioresistant. One such factor...
Source: Cancer and Metastasis Reviews - June 1, 2023 Category: Cancer & Oncology Source Type: research
Epigenetic changes and the dynamic heterogeneity of the metastatic phenotype – challenges ahead
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - May 30, 2023 Category: Cancer & Oncology Source Type: research
Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics
AbstractCancer is one of the life-threatening diseases accountable for millions of demises globally. The inadequate effectiveness of the existing chemotherapy and its harmful effects has resulted in the necessity of developing innovative anticancer agents. Thiazolidin-4-one scaffold is among the most important chemical skeletons that illustrate anticancer activity. Thiazolidin-4-one derivatives have been the subject of extensive research and current scientific literature reveals that these compounds have shown significant anticancer activities. This manuscript is an earnest attempt to review novel thiazolidin-4-one derivat...
Source: Cancer and Metastasis Reviews - May 19, 2023 Category: Cancer & Oncology Source Type: research
