Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression
This article provides a comprehensive review of mucin ’s function as a physical barrier and the implication of mucin overexpression in impeded drug delivery to solid tumors. Mucins regulate the epithelial to mesenchymal transition (EMT) of cancer cells via several canonical and non-canonical oncogenic signaling pathways. Furthermore, mucins play an e xtensive role in enriching and maintaining the cancer stem cell (CSC) population, thereby sustaining the self-renewing and chemoresistant cellular pool in the bulk tumor. It has recently been demonstrated that mucins regulate the metabolic reprogramming during oncogenesis an...
Source: Cancer and Metastasis Reviews - April 4, 2021 Category: Cancer & Oncology Source Type: research
A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression
AbstractCancer progression largely depends on tumor blood vessels as well on immune cell infiltration. In various tumors, vascular cells, namely endothelial cells (ECs) and pericytes, strongly regulate leukocyte infiltration into tumors and immune cell activation, hence the immune response to cancers. Recently, a lot of compelling studies unraveled the molecular mechanisms by which tumor vascular cells regulate monocyte and tumor-associated macrophage (TAM) recruitment and phenotype, and consequently tumor progression. Reciprocally, TAMs and monocytes strongly modulate tumor blood vessel and tumor lymphatic vessel formatio...
Source: Cancer and Metastasis Reviews - March 30, 2021 Category: Cancer & Oncology Source Type: research
The role of tumor heterogeneity in immune-tumor interactions
AbstractThe development of cancer stems from genetic instability and changes in genomic sequences, and hence, the heterogeneity exhibited by tumors is integral to the nature of cancer itself. Tumor heterogeneity can be further altered by factors that are not cancer cell intrinsic, i.e., by the microenvironment, including the patient ’s immune responses to tumors and administered therapies (immunotherapies, chemotherapies, and/or radiation therapies). The focus of this review is the impact of tumor heterogeneity on the interactions between immune cells and the tumor, taking into account that heterogeneity can exist at sev...
Source: Cancer and Metastasis Reviews - March 8, 2021 Category: Cancer & Oncology Source Type: research
Pancreatic cancer pathology viewed in the light of evolution
AbstractOne way to understand ductal adenocarcinoma of the pancreas (pancreatic cancer) is to view it as unimaginably large numbers of evolving living organisms interacting with their environment. This “evolutionary view” creates both expected and surprising perspectives in all stages of neoplastic progression. Advances in the field will require greater attention to this critical evolutionary prospective. (Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - February 8, 2021 Category: Cancer & Oncology Source Type: research
Potential late effects of SARS-CoV-2 (COVID-19) infection: parallels to cancer late effects
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - February 4, 2021 Category: Cancer & Oncology Source Type: research
