Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
AbstractPlasticity of phenotypic traits refers to an organism ’s ability to change in response to environmental stimuli. As a result, the response may alter an organism’s physiological state, morphology, behavior, and phenotype. Phenotypic plasticity in cancer cells describes the considerable ability of cancer cells to transform phenotypes through non-gene tic molecular signaling activities that promote therapy evasion and tumor metastasis via amplifying cancer heterogeneity. As a result of metastable phenotypic state transitions, cancer cells can tolerate chemotherapy or develop transient adaptive resistance. Therefor...
Source: Cancer and Metastasis Reviews - January 3, 2024 Category: Cancer & Oncology Source Type: research
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer —directs the road towards therapy resistance, metastatic progression and recurrence
AbstractRecent therapeutic advances have significantly uplifted the quality of life in breast cancer patients, yet several impediments block the road to disease-free survival. This involves unresponsiveness towards administered therapy, epithelial to mesenchymal transition, and metastatic progression with the eventual appearance of recurrent disease. Attainment of such characteristics is a huge adaptive challenge to which tumour cells respond by acquiring diverse phenotypically plastic states. Several signalling networks and mediators are involved in such a process. Glucocorticoid receptor being a mediator of stress respon...
Source: Cancer and Metastasis Reviews - January 3, 2024 Category: Cancer & Oncology Source Type: research
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
AbstractColorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes one of the most important challenges of the health system in many countries. Since the clinical symptoms of this cancer appear in the final stages of the disease and there is a significant golden time between the formation of polyps and the onset of cancer, early diagnosis can play a significant role in reducing mortality. Today, in addition to colonoscopy, minimally invasive methods such as liquid biopsy have received much attention. The treatment of this complex disease has been mostly based on...
Source: Cancer and Metastasis Reviews - December 19, 2023 Category: Cancer & Oncology Source Type: research
HOXA9 transcription factor is a double-edged sword: from development to cancer progression
AbstractThe HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor microenvironment in hematological and solid malignancies. However, the multiple modes of regulation, multifaceted functions, and context-dependent interactions responsible for the dual role of HOXA9 as an oncogene or tumor suppressor in cancer remain obscure. Hence, unravelling its molecular complexities, binding partners, and interacting signaling molecules enables us to comprehend HOXA9-mediated transcriptional programs and molecular crosstalk. Howe...
Source: Cancer and Metastasis Reviews - December 8, 2023 Category: Cancer & Oncology Source Type: research
Biography —Mathieu Boissan, Pharm.D., Ph.D
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - December 1, 2023 Category: Cancer & Oncology Source Type: research
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic reprogramming.De novo lipogenesis is under the control of the transcription factor sterol regulatory element-binding protein 1 (SREBP-1) and essentially contributes to HCC progression. Here, we summarize the current knowledge on the regulation of SREBP-1 isoforms in HCC based on cellular, animal, and clinical data. Specifically, we (i) address the overarching mechanisms for regulating SREBP-1 transcription, proteolytic processing, nuclear stability, and t...
Source: Cancer and Metastasis Reviews - December 1, 2023 Category: Cancer & Oncology Source Type: research
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
AbstractThis comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on mitigating metastasis and overcoming drug resistance. Vimentin, a key player in cancer progression, is intricately involved in processes such as epithelial-to-mesenchymal transition (EMT) and resistance mechanisms to standard cancer therapies. The review delves into diverse vimentin inhibition strategies. Precision tools, including antibodies and nanobodies, selectively neutralize vimentin's pro-tumorigenic effects. DNA and RNA aptamers disrupt vimentin-associated signaling pathways through their...
Source: Cancer and Metastasis Reviews - November 28, 2023 Category: Cancer & Oncology Source Type: research
Metastasis suppressor genes and their role in the tumor microenvironment
AbstractThe metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment. (Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - November 20, 2023 Category: Cancer & Oncology Source Type: research
Tumor ablation induced anti-tumor immunity: destruction of the tumor in situ with the aim to evoke a robust anti-tumor immune response
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - November 11, 2023 Category: Cancer & Oncology Source Type: research
From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies
AbstractMYB transcription factors are encoded by a large family of highly conserved genes from plants to vertebrates. There are three members of the MYB gene family in human, namely,MYB,MYBL1, andMYBL2 that encode MYB/c-MYB, MYBL1/A-MYB, and MYBL2/B-MYB, respectively. MYB was the first member to be identified as a cellular homolog of the v-myb oncogene carried by the avian myeloblastosis virus (AMV) causing leukemia in chickens. Under the normal scenario, MYB is predominantly expressed in hematopoietic tissues, colonic crypts, and neural stem cells and plays a role in maintaining the undifferentiated state of the cells. Ov...
Source: Cancer and Metastasis Reviews - November 10, 2023 Category: Cancer & Oncology Source Type: research
Preface
(Source: Cancer and Metastasis Reviews)
Source: Cancer and Metastasis Reviews - November 8, 2023 Category: Cancer & Oncology Source Type: research
Prospects of earthworm coelomic fluid as a potential therapeutic agent to treat cancer
AbstractCancer is a major public health concern because it is one of the main causes of morbidity and mortality worldwide. As a result, numerous studies have reported the development of new therapeutic compounds with the aim of selectively treating cancer while having little negative influence on healthy cells. In this context, earthworm coelomic fluid has been acknowledged as a rich source of several bioactive substances that may exhibit promising anticancer activity. Therefore, the objective of the present review is to evaluate the findings of the reported studies exploring the antitumor effects of coelomic fluid in the ...
Source: Cancer and Metastasis Reviews - November 1, 2023 Category: Cancer & Oncology Source Type: research
Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer
Abstract Air pollutants are increasingly emitted into the atmosphere because of the high dependency of humans on fossil-derived fuels. Wind speed and direction assisted high dispersibility and uncontrolled nature of air pollution across geo-/demographical borders, making it one of the major global concerns. Besides climate change, air pollution has been found to be associated with various diseases, such as cancer. Lung cancer, which is the world ’s most common type of cancer, has been found to be associated with traffic-related air pollution. Research and political efforts have been taken to explore green/renewable energ...
Source: Cancer and Metastasis Reviews - November 1, 2023 Category: Cancer & Oncology Source Type: research
Clonal tracking in cancer and metastasis
AbstractThe eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous clones maintained by rare cancer stem cells (CSCs), which contribute to disease progression, treatment refractoriness, and late relapse. The characterization of functional CSC activity has necessitated the development of modern clonal tracking strategies. This review describes viral-based and CRISPR-Cas9-based cellular barcoding, lineage tracing, and imaging-based approaches. DNA-based cellular barcoding technology is emerging as a powerful and robust strategy that has been widely applied toin vi...
Source: Cancer and Metastasis Reviews - November 1, 2023 Category: Cancer & Oncology Source Type: research
