Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial
ConclusionsThe results obtained herein will aid in inferring the aggressiveness of small ccRCCs, represented by ISUP nuclear grade, in clinical practice. Our findings indicated thatDDX11 and visceral fat play active roles in small ccRCC. These roles should be examined in future studies for the possible use ofDDX11 and visceral fat as prognostic biomarkers in the treatment of patients with ccRCC.Trial registrationClinicalTrials.gov,NCT03694912, Registered 3 October 2018. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 6, 2021 Category: Cancer & Oncology Source Type: research
A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism
ConclusionsDRB18 is a potent pan-class I GLUT inhibitor in vitro and in vivo in cancer cells. Mechanistically, it is likely to bind the outward open conformation of GLUT1-4, reducing tumor growth through inhibiting GLUT1-4-mediated glucose transport and metabolisms. Pan-class I GLUT inhibition is a better strategy than single GLUT targeting for inhibiting tumor growth. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 26, 2021 Category: Cancer & Oncology Source Type: research
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase
ConclusionsWe show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation. This indicates that fructose uptake is the limiting factor for fructose-mediated cell proliferation. We further demonstrate that cellular proliferation with fructose is independent of KHK. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 24, 2021 Category: Cancer & Oncology Source Type: research
Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes
ConclusionsOverall, our findings suggest thatIDH mutations induce global metabolic changes in chondrosarcomas and shed light on deranged metabolic pathways. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 24, 2021 Category: Cancer & Oncology Source Type: research
GLUT5 ( SLC2A5 ) enables fructose-mediated proliferation independent of ketohexokinase
ConclusionsWe show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation. This indicates that fructose uptake is the limiting factor for fructose-mediated cell proliferation. We further demonstrate that cellular proliferation with fructose is independent of KHK. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 24, 2021 Category: Cancer & Oncology Source Type: research
Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models
ConclusionsSSZ could improve CCA therapy by sensitization to CIS through killing CD44v9-positive cells and modifying the metabolic pathways, in particular tryptophan degradation (i.e., kynurenine pathway, serotonin pathway) and nucleic acid metabolism. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 16, 2021 Category: Cancer & Oncology Source Type: research
The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
ConclusionsOur data identified previously unknown roles of PD-L1 in cancer cell metabolic reprogramming, and revealed the immunosuppressive increased PD-L1 effect of Chk- α downregulation. These data suggest that PD-L1 regulation of metabolism may be mediated through Chk-α, COX-2, and TGF-β. The observations provide new insights that can be applied to the rational design of combinatorial therapies targeting immune checkpoints and cancer metabolism. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 19, 2021 Category: Cancer & Oncology Source Type: research
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI
ConclusionsThis study shows that specific tissue compartments within prostate cancer samples have distinct metabolic profiles and pinpoint the advantage of methodology providing spatial information compared to bulk analysis. We identified several differential metabolites and lipids that have potential to be developed further as diagnostic and prognostic biomarkers for prostate cancer. Spatial and rapid detection of cancer-related analytes showcases MALDI-TOF MSI as a promising and innovative diagnostic tool for the clinic. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 29, 2021 Category: Cancer & Oncology Source Type: research
RNF115 promotes lung adenocarcinoma through Wnt/ β-catenin pathway activation by mediating APC ubiquitination
ConclusionThe current study reveals a close association between RNF115 expression and prognostic conditions in LUAD patients and the oncogenic roles of RNF115 in LUAD at the first time. These findings may help establish the foundation for the development of therapeutics strategies and clinical management for lung cancer in future. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 28, 2021 Category: Cancer & Oncology Source Type: research
Prognostic value of metabolic tumor volume and total lesion glycolysis on preoperative 18 F-FDG PET/CT in patients with localized primary gastrointestinal stromal tumors
ConclusionMTV and TLG are independent prognostic factors for predicting recurrence in patients with localized primary GIST. Patients with a high MTV or TLG are at risk for poor prognosis and should be closely observed for disease recurrence. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 28, 2021 Category: Cancer & Oncology Source Type: research
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
ConclusionsAltogether, the multifaceted metabolic reprogramming induced by DASA-58 in breast cancer cells increases their susceptibility to other therapeutics suggesting the suitability of the intracellular glucose sensor TXNIP as a marker of PK activity. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 22, 2021 Category: Cancer & Oncology Source Type: research
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
ConclusionsVia its enzymatic activity, SIRT6 enhances PDH expression and activity, OXPHOS, ATP/AMP ratio, and intracellular calcium concentration, while reducing AMPK activation, in BC cells. Thus, overall, SIRT6 inhibition appears as a viable strategy for preventing or treating BC. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 22, 2021 Category: Cancer & Oncology Source Type: research
Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells
ConclusionsThe translation-dependent sensor developed here is able to accurately track the development of resistance in ASS1-deficient cells treated with ADI-PEG20. Its ability to track single cells over time allowed the determination that resistance is not present in the na ïve population, as well as elucidating the heterogeneity of the timing and extent of resistance. This tool represents a useful advance in the study of arginine deprivation, while its design has potential to be adapted to other amino acids. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 21, 2021 Category: Cancer & Oncology Source Type: research
Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells
ConclusionsThese findings indicate that growth media conditions have substantial effects on the energy metabolism of subcultured tumor-derived cells, which may have significant implications for chemotherapeutic sensitivity during incorporation in IOX testing panels. Additionally, the metabolic phenotyping approach used in this study provides a practical workflow that can be incorporated with IOX screening practices to aid in deciphering the metabolic underpinnings of chemotherapeutic drug sensitivity. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 19, 2021 Category: Cancer & Oncology Source Type: research
The diversity and breadth of cancer cell fatty acid metabolism
AbstractTumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, ...
Source: Cancer and Metabolism - January 7, 2021 Category: Cancer & Oncology Source Type: research
