BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells
ConclusionThese results demonstrate that BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in HCC cells, which may be exploited as novel therapeutic targets for HCC treatment. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - July 13, 2023 Category: Cancer & Oncology Source Type: research
Obesity and breast cancer prognosis: pre-diagnostic anthropometric measures in relation to patient, tumor, and treatment characteristics
ConclusionHigher pre-diagnostic BMI, waist circumference, and body fat percentage was associated with increased risk of BCR. The association between obesity and BCR appears dependent on patient, tumor, and treatment characteristics. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - June 27, 2023 Category: Cancer & Oncology Source Type: research
Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer
ConclusionOur study reports the presence of platinum-resistant lung tumors that utilize both IDO1/TDO2 enzymes for survival, and to escape immune surveillance as a consequence of KYN metabolites. We also report early in vivo data in support of the potential therapeutic efficacy of the dual IDO1/TDO2 inhibitor AT-0174 as a part of immuno-therapeutic treatment that disrupts tumor metabolism and enhances anti-tumor immunity. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 24, 2023 Category: Cancer & Oncology Source Type: research
Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study
ConclusionsDapagliflozin is well-tolerated and was associated with high compliance in patients with advanced, inoperable PDAC. Overall favorable changes in tumor response and plasma biomarkers suggest it may have efficacy against PDAC, warranting further investigation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 18, 2023 Category: Cancer & Oncology Source Type: research
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia
ConclusionsIn conclusion, our findings indicate that ChREBP activity limits hepatomegaly while decelerating liver disease progression and protecting against chromosomal instability in hepatic GSD Ia. These results disqualify ChREBP as a therapeutic target for treatment of liver disease in GSD Ia. In addition, they underline the importance of establishing the context-specific roles of hepatic ChREBP to define its therapeutic potential to prevent or treat advanced liver disease. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 21, 2023 Category: Cancer & Oncology Source Type: research
Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells
In this study, the metabolic phenotypes of breast cancer cell lines with low (T47D) or high (MDA-MB-231) metastatic potential, as well as lung (LM)- and bone (BoM)-homing lines derived from MDA-MB-231 cells, were assessed by13C metabolite labeling from [1,2-13C] glucose or [5-13C] glutamine and the rates of nutrient and oxygen consumption and lactate production. MDA-MB-231 and T47D cells produced 55 and 63%, respectively, of ATP from oxidative phosphorylation, whereas LM and BoM cells were more glycolytic, deriving only 20 –25% of their ATP from mitochondria. ATP demand by BoM and LM cells was approximately half the rate...
Source: Cancer and Metabolism - February 20, 2023 Category: Cancer & Oncology Source Type: research
Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer
ConclusionMechanisms underlying tamoxifen-induced radioresistance are linked to cellular adaptations to persistently increased ROS levels, leading to cells with chronically upregulated antioxidant capacity and glycolysis. Pharmacological inhibition of antioxidant responses re-sensitizes breast cancer cells to irradiation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 8, 2023 Category: Cancer & Oncology Source Type: research
Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia
AbstractAcute lymphoblastic leukemia (ALL) and its treatment continue to pose substantial risks. To understand ALL more deeply, the metabolome in fasting plasma of 27 ALL patients before and after high-dose methotrexate therapies (consolidation therapy) including methotrexate and 6-mercaptopurine (6-MP) was investigated. Plasma metabolites were analyzed using liquid chromatography –tandem mass spectrometry (LC–MS). Orthogonal projections to latent structures discriminant analysis and significance analysis of microarrays were used to evaluate the metabolic changes. Pathway enrichment and co-expression network analyses w...
Source: Cancer and Metabolism - January 23, 2023 Category: Cancer & Oncology Source Type: research
Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells
ConclusionActivation of ARG1 is related to the migration ability and metastatic colonization of colon cancer cells, and blockade of this process may be a novel strategy for controlling cancer malignancy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - January 13, 2023 Category: Cancer & Oncology Source Type: research
Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma
ConclusionOur study adds functional metabolic phenotyping to transcriptome-based analysis and proposes a functional approach to identify highly glycolytic PDACs as candidates for antimetabolic therapeutic avenues. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 9, 2022 Category: Cancer & Oncology Source Type: research
PDK1- and PDK2-mediated metabolic reprogramming contributes to the TGF β1-promoted stem-like properties in head and neck cancer
ConclusionThe results demonstrated that the PDK1- and PDK2-mediated Warburg effect contributes to the TGF β1-enhanced stemness properties of HNC. Therefore, PDK1 and PDK2 may serve as molecular targets for the combination therapy of HNC. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 6, 2022 Category: Cancer & Oncology Source Type: research
Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer
ConclusionsOur data indicates that PRMT5 promoted colorectal cancer proliferation partially through activating glycolysis and may be a potential target for colorectal cancer therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 6, 2022 Category: Cancer & Oncology Source Type: research
Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity
ConclusionsHere, we highlight the importance of understanding metabolism in non-obesity-associated cancers, such as melanoma. This work advances the understanding of the correlation between metabolism and immunogenicity in the tumor microenvironment and provides evidence supporting metabolic gene expression as potential prognostic factors of melanoma progression and may inform investigations of adjunctive metabolic therapy in melanoma.Trial registrationDeidentified data from The Cancer Genome Atlas were analyzed. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 1, 2022 Category: Cancer & Oncology Source Type: research
Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism
ConclusionsOur study demonstrates molecular mechanisms of the SNHG16-mediated 5-Fu resistance of GC cells through modulating the miR-506-3p-PTBP1-glucose metabolism axis, presenting a promising approach for anti-chemoresistance therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 29, 2022 Category: Cancer & Oncology Source Type: research
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study
ConclusionsLow SMI was associated with worse survival. High VAT predicted better survival in men but worse survival in women. The results suggest that CT-measured body composition is a useful tool for evaluating the prognosis of rectal cancer patients and demonstrate the need to include the sex and the tumour location in the analyses. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 23, 2022 Category: Cancer & Oncology Source Type: research
