Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
ConclusionsWe found that a physiological level of 3-OHB can change the energetic profile of some BC cell lines. However, 3-OHB failed to influence different biologic processes in these cells, e.g., cell proliferation and the response to common breast cancer chemotherapy and radiotherapy. Thus, we have no evidence that 3-OHB generally influences the biology of breast cancer cells in vitro. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - June 11, 2018 Category: Cancer & Oncology Source Type: research
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
ConclusionsWhile PKM2 is not required for soft tissue sarcoma growth, PKM2 expression may facilitate initiation of this tumor type. Because these data differ from what has been observed in other cancer models where PKM2 has been deleted, they argue that the consequences ofPKM2 loss during tumor initiation are dependent on the tumor type. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 31, 2018 Category: Cancer & Oncology Source Type: research
Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
ConclusionsThese results demonstrate that IDH1 mutant and IDH wildtype cells are easily distinguishable metabolically by analyzing expression profiles and glucose consumption. Our results also highlight important differences in nucleotide synthesis utilization and DNA repair capacity that could be exploited for therapy. Altogether, this study demonstrates that IDH1 mutant gliomas are a distinct subclass of glioma with a less malignant, but also therapy-resistant, metabolic profile that will likely require distinct modes of therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 17, 2018 Category: Cancer & Oncology Source Type: research
Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
ConclusionsThis study identifies oncogene-induced metabolic reprogramming within mouse breast tumors and compares the results to that of human breast tumors, providing a unique look at the relationship between and clinical value of oncogene initiation and metabolism during breast cancer. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 3, 2018 Category: Cancer & Oncology Source Type: research
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
ConclusionsThis study identifies, to our knowledge for the first time, a direct role for 2-HG in the downregulation of CK and EK activity, and thereby, PC and PE synthesis in IDHmut gliomas. These results highlight the unusual reprogramming of phospholipid metabolism in IDHmut gliomas and have implications for the identification of MRS-detectable metabolic biomarkers associated with 2-HG status. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 3, 2018 Category: Cancer & Oncology Source Type: research
Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
ConclusionsThis study identifies oncogene-induced metabolic reprogramming within mouse breast tumors and compares the results to that of human breast tumors, providing a unique look at the relationship between and clinical value of oncogene initiation and metabolism during breast cancer. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 3, 2018 Category: Cancer & Oncology Source Type: research
Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner
ConclusionsThis study identifies, to our knowledge for the first time, a direct role for 2-HG in the downregulation of CK and EK activity, and thereby, PC and PE synthesis in IDHmut gliomas. These results highlight the unusual reprogramming of phospholipid metabolism in IDHmut gliomas and have implications for the identification of MRS-detectable metabolic biomarkers associated with 2-HG status. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 3, 2018 Category: Cancer & Oncology Source Type: research
Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state
ConclusionThese findings unraveled the involvement of adipokines (leptin and resistin) in melanoma progression, and more importantly, in the outcome of DTIC therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 20, 2018 Category: Cancer & Oncology Source Type: research
Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
ConclusionsOur study identifies novel mechanisms of resistance to NAMPT inhibition, which may be useful to design more rational strategies for targeting cancer metabolism. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 8, 2018 Category: Cancer & Oncology Source Type: research
