Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer
ConclusionAltogether, this study provides evidence that changes to tumor cell mitochondrial metabolism may underlie in part the benefits of exercise. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 15, 2018 Category: Cancer & Oncology Source Type: research
Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice
ConclusionsWe report herein that a dietary intervention can improve ALL outcome in a preclinical model. Further work is needed to identify the mechanisms of this effect and investigate potential impact on human leukemia in patients. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 1, 2018 Category: Cancer & Oncology Source Type: research
Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9)
ConclusionTaken together, these results suggest a regulation of PCSK9 by high glucose which could contribute, at least partly, towards understanding the cause of hypercholesterolemia in HCC and its accompanied upshots in terms of altered response of HCC cells towards cancer therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 25, 2018 Category: Cancer & Oncology Source Type: research
PKM2 is not required for pancreatic ductal adenocarcinoma
ConclusionsPKM2 is not required for initiation or growth of PDAC tumors arising in the KP−/−C pancreatic cancer model. These findings suggest that, in this mouse PDAC model, PKM2 expression is not required for pancreatic tumor formation or progression. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 23, 2018 Category: Cancer & Oncology Source Type: research
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation
ConclusionsTaken together, our findings suggest a novel function of MTHFD2 in RNA metabolism and translation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - September 27, 2018 Category: Cancer & Oncology Source Type: research
CD38 is methylated in prostate cancer and regulates extracellular NAD +
ConclusionsCD38 protein expression in prostate cancer is associated with risk of recurrence. Methylation results suggest that CD38 is epigenetically regulated in localized and metastatic prostate cancer tissues. Our study provides support for CD38 as a regulator of extracellular, but not intracellular, NAD+ in epithelial cells. These findings suggest that repression of CD38 by methylation may serve to increase the availability of extracellular NAD+ in prostate cancer tissues. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - September 21, 2018 Category: Cancer & Oncology Source Type: research
Activation of pro-survival metabolic networks by 1,25(OH) 2 D 3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics
ConclusionsAltogether, we propose that regulation of energy metabolism contributes to 1,25(OH)2D3’s anti-cancer effects and that combining 1,25(OH)2D3 with drugs targeting metabolic networks in tumor cells may lead to synergistic effects. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - August 30, 2018 Category: Cancer & Oncology Source Type: research
Hexokinase 2 is dispensable for T cell-dependent immunity
ConclusionsHK2 is a highly upregulated enzyme in cancer and in T cells. The requirement for HK2 in various cancer models has been described previously. Our finding that T cells are able to withstand the loss of HK2 indicates that HK2 may be a promising candidate for cancer therapy. Furthermore, we identify several other potential metabolic targets in T-ALL leukemia that could spare T cell function. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - August 17, 2018 Category: Cancer & Oncology Source Type: research
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors
ConclusionsThese results suggest that inflammation-induced DNA methylation and silencing ofPolg plays an important role in the tumorigenesis process by resulting in reduced mitochondria levels and altered metabolism. An enhanced understanding of how metabolism is altered in and drives inflammation-induced tumorigenesis will provide potential therapeutic targets. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - July 10, 2018 Category: Cancer & Oncology Source Type: research
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
ConclusionsThe HK1−HK2+ cancer subsets exist among a wide variety of cancer types. Selective inhibition of the HK1−HK2+ cancer cell-specific energy production pathways (HK2-driven glycolysis, oxidative phosphorylation and fatty acid oxidation), due to the unique presence of only the HK2 isoform, appears promising to treat HK1−HK2+ cancers. This therapeutic strategy will likely be tolerated by most normal tissues, where only HK1 is expressed. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - June 28, 2018 Category: Cancer & Oncology Source Type: research
