Molecular characterization of Gleason patterns 3 and 4 prostate cancer using reverse Warburg effect-associated genes
Conclusions
We report that RWE-associated genes can be used to distinguish between GP3 and GP4 prostate cancers. Moreover, we find that the RWE response is downregulated in the stroma surrounding GP4, possibly via modulation of FOXO1. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 4, 2016 Category: Cancer & Oncology Source Type: research
Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells
Conclusion
This study indicates a differential metabolic response between the methionine sensitive MDA-MB-468 cells and the methionine insensitive derivative cell line MDA-MB-468res-R8. Both cell lines appear to experience oxidative stress when methionine was replaced with its metabolic precursor homocysteine, forcing cells to redirect homocysteine metabolism toward the transsulfuration pathway to increase glutathione synthesis. The methionine stress resistant MDA-MB-468res-R8 cells responded to this cellular stress earlier than the methionine stress sensitive MDA-MB468 cells and coped better with met...
Source: Cancer and Metabolism - May 1, 2016 Category: Cancer & Oncology Source Type: research
Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis
Conclusions
Differential stable isotope labeling analysis provides qualitative metabolic flux information in a non-targeted manner. Furthermore, similarity analysis of enrichment patterns provides information on metabolically closely related compounds. N-acetylaspartate and NAT8L are important players in cancer cell metabolism, a context in which they have not received much attention yet. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 22, 2016 Category: Cancer & Oncology Source Type: research
Pre-diagnosis blood glucose and prognosis in women with breast cancer
Conclusions
The data suggest that elevated blood glucose is associated with poor prognosis of breast cancer patients. Given the potential clinical implication, these findings warrant further investigation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 5, 2016 Category: Cancer & Oncology Source Type: research
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Conclusions
Our data implicate lipid desaturation as an essential process for cancer cell survival and suggest that targeting SCD could efficiently limit tumour expansion, especially under the metabolically compromised conditions of the tumour microenvironment. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 31, 2016 Category: Cancer & Oncology Source Type: research
Profiling cancer metabolism at the ‘omic’ level: a last resort or the next frontier?
(Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 21, 2016 Category: Cancer & Oncology Source Type: research
Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
Abstract
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Warburg to illustrate some of these influences an...
Source: Cancer and Metabolism - March 8, 2016 Category: Cancer & Oncology Source Type: research
Warburg effect(s) —a biographical sketch of Otto Warburg and his impacts on tumor metabolism
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Otto Warburg to the discovery of this observation and how his other scientific contributions are seminal to our present knowledge of metabolic and energetic processes in cells. Since science is a human endeavor, and a scientist is imbedded in a network of social and academic contacts, it is worth taking a glimpse into the biography of Otto Wa...
Source: Cancer and Metabolism - March 7, 2016 Category: Cancer & Oncology Source Type: research
Integration of omics: more than the sum of its parts
Abstract
Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites. The cellular components from which these -omics regimes are derived act as one integrated system in vivo; thus, there is a natural instinct to integrate -omics data types. Statistical analyses, the use of previous knowledge in the form of networks, and the use of time-resolved measurements are three key design elements for life scientists to consider in planning integrated -omics studies. These design elements are reviewed ...
Source: Cancer and Metabolism - February 19, 2016 Category: Cancer & Oncology Source Type: research
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
Conclusions
We provide evidence that connects the inflammatory mediator OSM to a hypoxia-like metabolic phenotype. In the human hepatocyte cell line PH5CH, OSM-mediated upregulation of HIF-1 α and PDK1 can induce hypoxia-like metabolic changes, although to a lesser extent than hypoxia itself. Since PDK1 is overexpressed in several cancers, it might provide a causal link between chronic inflammation and malignant cellular transformation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 17, 2016 Category: Cancer & Oncology Source Type: research
Metabolism and microenvironment in cancer plasticity
Abstract
Major contributions of the 2nd annual meeting of the International Society of Cancer Metabolism, held in Venice, September 16–19, 2015, are here described and discussed. Among these, the impact of cancer metabolism on local and systemic aggressiveness was analyzed in the context of interactions between cancer and stroma, microenvironmental changes, epigenetic, and stemness modulation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 15, 2016 Category: Cancer & Oncology Source Type: research
Mathematical models of cancer metabolism
Abstract
Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands of cancer cells, including but not limited to cell proliferation and cell migration. In recent years, there have been a number of new discoveries connecting known aberrations in oncogenic and tumour suppressor pathways with metabolic alterations required to sustain cell proliferation and migration. However, an understanding of the selective advantage of these metabolic alterations is stil...
Source: Cancer and Metabolism - December 22, 2015 Category: Cancer & Oncology Source Type: research
Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells
Conclusions
Taken together, we conclude that 2HG carbon is not readily transformed in the HCT116 cell line. These data indicate that the phenotypic alterations induced by 2HG are not a result of its metabolic products. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 1, 2015 Category: Cancer & Oncology Source Type: research
Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth
Conclusions
Taken together, our results suggest that complex I inhibition has potential clinical applications as a single agent in melanoma and also might be efficacious in combination with BRAF inhibitors in the treatment of patients with BRAF mutant melanoma. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 20, 2015 Category: Cancer & Oncology Source Type: research
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
Conclusions
This treatment strategy illustrates proof of principle that simultaneously decreasing glutamine metabolism-dependent tumor anti-oxidant defenses and inducing supra-physiological ROS formation are tumoricidal and that this rationally designed combination strategy lowers the required doses of both agents in vitro and in vivo. The non-overlapping specificities of GLS1 inhibitors and ß-lap for PDA tumors afford high tumor selectivity, while sparing normal tissue. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 12, 2015 Category: Cancer & Oncology Source Type: research
