The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin ’s lymphoma—an observational study
ConclusionsThe presence of metabolic abnormalities with or without obesity increased the risk of non-selective readmission in patients with NHL. However, obesity alone had no associations with the risk of non-selective readmission, suggesting that interventions for metabolic abnormalities may be more important in reducing readmissions of NHL patients. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 6, 2023 Category: Cancer & Oncology Source Type: research
Metabolic changes preceding bladder cancer occurrence among Korean men: a nested case-control study from the KCPS-II cohort
ConclusionMetabolic signatures shown in the present research may be closely associated with BLCA pathogenesis. Metabolites involved in these could be predictive biomarkers for BLCA. It could be utilized for early diagnosis, prognostic diagnosis, and therapeutic targets for BLCA. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - December 5, 2023 Category: Cancer & Oncology Source Type: research
Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages
ConclusionsOverall, the findings of this study suggest that autofluorescence metabolic imaging could be a reliable technique for longitudinal tracking of immune cell metabolism during activation post-cytokine stimulation. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 13, 2023 Category: Cancer & Oncology Source Type: research
The effects of chemotherapy on resting energy expenditure, body composition, and cancer-related fatigue in women with breast cancer: a prospective cohort study
ConclusionsWomen with BC have higher REE in the tumor-bearing state compared to healthy controls. Chemotherapy does not affect REE but alters body composition. Predictive equations are invalid in the BC population. Results of our study can be used to implement personalized nutritional interventions to support energy expenditure and body composition and minimize long-term comorbidities. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 9, 2023 Category: Cancer & Oncology Source Type: research
ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors
ConclusionsInhibition of ATM reduced both glycolytic enzymes and OXPHOS levels in oncogene-driven cancer cells and enhanced apoptosis induced by driver inhibitors thus highlighting the possibility to use ATM and the driver inhibitors in combined regimens of anticancer therapy in vivo. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 6, 2023 Category: Cancer & Oncology Source Type: research
Correction: Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
(Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 26, 2023 Category: Cancer & Oncology Source Type: research
Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
ConclusionsTogether, these results show that aspirin leads to significant metabolic reprogramming in colorectal cancer cells and raises the possibility that aspirin could significantly increase the efficacy of metabolic cancer therapies in CRC. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 19, 2023 Category: Cancer & Oncology Source Type: research
Untargeted plasma metabolomics and risk of colorectal cancer —an analysis nested within a large-scale prospective cohort
ConclusionsThese findings suggest that although the circulating metabolome may provide new etiological insights into the underlying causes of CRC development, its potential application for the identification of individuals at higher risk of developing CRC is limited. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 17, 2023 Category: Cancer & Oncology Source Type: research
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling
ConclusionsOur data identified specific metabolite profiles that reflect the pathogenesis of EMC and showed that these metabolites correlate with the risk of recurrence and disease stage. Analysis of changes in plasma metabolite profiles could be applied for the early diagnosis and monitoring of the course of treatment of EMC patients. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 11, 2023 Category: Cancer & Oncology Source Type: research
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
AbstractHypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the role of increased circulatory cholesterol or dietary cholesterol intake towards cancer etiology and pathology. Recently, abnormality in the blood cholesterol level of colon cancer patients has been reported. In the present study, we demonstrate that alteration in cholesterol levels (through a high-cholesterol or high-fat diet) increases the incidence of chemical carcinogen-induced colon polyp occurrence and tum...
Source: Cancer and Metabolism - September 13, 2023 Category: Cancer & Oncology Source Type: research
Positron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo
ConclusionsNIS acts as a rapid metabolic sensor for drugs that lead to ATP depletion. PET imaging of NIS could facilitate in vivo testing of treatments targeting energetic pathways, determine drug potency, and expedite metabolic drug development. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - September 7, 2023 Category: Cancer & Oncology Source Type: research
Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states
ConclusionsThis study is, to our knowledge, the first to report human plasma metabolic differentials between in vivo KSHV infection and co-infection with HIV, as well as differentials between co-infection and epidemic KS. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - August 31, 2023 Category: Cancer & Oncology Source Type: research
Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells
AbstractThe use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings of conventional treatments. The ability of anaerobic bacteria to preferentially accumulate and replicate in hypoxic regions of solid tumors, as a consequence of bacterial metabolic needs, is particularly advantageous and key to boosting their immunostimulatory therapeutic actions in situ. While several of these bacterial traits are well-studied, little is known about their competition for nutrients and its effect on cancer cells which could serve as another potent and innate antineoplastic action. Here, we explored the consequ...
Source: Cancer and Metabolism - August 9, 2023 Category: Cancer & Oncology Source Type: research
Restoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma
ConclusionsOur study suggests that the deficiency of gluconeogenesis is a key metabolic feature of KIRC, and restoring gluconeogenesis could effectively inhibit the proliferation and progression of KIRC cells. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - August 8, 2023 Category: Cancer & Oncology Source Type: research
Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells
AbstractMelanoma is considered as the most common metastatic skin cancer with increasing incidence and high mortality globally. The vital roles of long non-coding RNAs (lncRNAs) in the tumorigenesis of melanoma are elucidated by emerging evidence. The lncRNA cervical carcinoma high-expressed 1 (CCHE1) was overexpressed and acted as an oncogene in a variety of cancers, while the function of CCHE1 in melanoma remains unclear. Here, we found that CCHE1 was highly expressed in melanoma and correlated with the poorer survival of melanoma patients. Depletion of CCHE1 inhibited the proliferation, induced cell apoptosis and suppre...
Source: Cancer and Metabolism - July 21, 2023 Category: Cancer & Oncology Source Type: research
