Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1
ConclusionThis study provides new perspectives on LAT1-dependent cellular processes and a rationale for therapeutics targeting reprogrammed cancer metabolism. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - November 10, 2022 Category: Cancer & Oncology Source Type: research
Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment
AbstractContrary to the “obesity paradox,” which arises from retrospective studies relying on body mass index to define obesity, epidemiologic evidence suggests central or visceral obesity is associated with a higher risk for the development of lung cancer. About 60% of individuals at high risk for developing lung canc er or those already with early-stage disease are either overweight or obese. Findings from resected patient tumors and mouse lung tumor models show obesity dampens immune activity in the tumor microenvironment (TME) encouraging disease progression. In line with this, we have observed a marked, obesi ty-s...
Source: Cancer and Metabolism - October 26, 2022 Category: Cancer & Oncology Source Type: research
Scaffold-mediated switching of lymphoma metabolism in culture
Conclusion3D culture restrained DLBCL cell line growth and modulated metabolic pathways that trend towards the biological characteristics of patient tumors. Counter-intuitively, this research thereby contends that 3D matrices can be a tool to control tumor function towards a slower growing and metabolically dormant state that better reflects in vivo tumor physiology. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 12, 2022 Category: Cancer & Oncology Source Type: research
Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls
ConclusionsPlasma-based metabolomic detection of early-stage NSCLC appears feasible. Further metabolomics studies targeting phospholipid, steroid, and fatty acid metabolism are warranted to further develop noninvasive metabolomics-based detection of early-stage NSCLC. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 12, 2022 Category: Cancer & Oncology Source Type: research
ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma
ConclusionsACSL3 regulates the accumulation of lipid droplets in ccRCC and is essential for tumor growth. In addition, ACSL3 also modulates ferroptosis sensitivity in a manner dependent on the composition of exogenous fatty acids. Both functions of ACSL3 could be exploited for ccRCC therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - October 3, 2022 Category: Cancer & Oncology Source Type: research
Integrative analysis of plasma metabolomics and proteomics reveals the metabolic landscape of breast cancer
ConclusionsThis study uncovered specific changes in the metabolic and proteomic profiling of breast cancer patients and identified a panel of 47 plasma metabolites, including sphingomyelins, glutamate, and cysteine could be potential diagnostic biomarkers for breast cancer. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - August 17, 2022 Category: Cancer & Oncology Source Type: research
Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity
ConclusionsKetogenic diets induced antitumor effects toward melanoma regardless of the tumors ´ genetic background, its metabolic signature, and the host immune status. Moreover, ketogenic diets simultaneously affected multiple metabolic pathways to create an unfavorable environment for melanoma cell proliferation, supporting their potential as a complementary nutritional approach to melano ma therapy. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - July 18, 2022 Category: Cancer & Oncology Source Type: research
13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo
ConclusionsAltogether, our results show that recycling of endogenous CO2 is substantial in vivo. The production and recycling of13CO2 from the decarboxylation of [U-13C]-glucose or [U-13C]-glutamine is negligible in vitro partially due to dilution by the exogenous HCO3−/CO2 source, but in vivo incorporation of endogenous13CO2 into M + 1 metabolites is substantial and should be considered. These findings provide a new paradigm to understand carbon atom transformations in vivo and should be taken into account when developing mathematical models to better reflect carbon flux. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - July 7, 2022 Category: Cancer & Oncology Source Type: research
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
ConclusionDrugs that cause DNA replication stress increase the metabolism of CRC cells. Glucose restriction might improve the effectiveness of classical chemotherapy against p53-positive CRC cells.Graphical AbstractThe topoisomerase-1 inhibitor irinotecan and other chemotherapeutics that cause DNA damage induce metabolic adaptations in colorectal cancer (CRC) cells irrespective of their p53 status. Irinotecan enhances the glycolysis and oxygen consumption in CRC cells to deliver energy and biomolecules necessary for DNA repair and their survival. Compared to p53-deficient cells, p53-proficient CRC cells have a more active ...
Source: Cancer and Metabolism - July 4, 2022 Category: Cancer & Oncology Source Type: research
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
ConclusionsIn this study of CRC and PDAC cell lines, we demonstrate that glucose metabolism in 3D spheroids differs significantly from 2D cultures, both in terms of glycolytic and oxidative phosphorylation metrics. The metabolic phenotype shift from 2D to 3D culture in one cell line is greater than the phenotypic differences between each cell line and tumor source. The results herein emphasize the need to use 3D cell models for investigating nutrient utilization and metabolic flux for a better understanding of tumor metabolism and potential metabolic therapeutic targets. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 16, 2022 Category: Cancer & Oncology Source Type: research
An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells
ConclusionCombination therapy involving administration of DFO and CHC is effective in cancer cells wherein DFO treatment results in an elevation in lactate levels. Our findings illustrate that the DFO-induced enhanced glycolysis provides specific targets for developing an efficient anticancer combinatorial therapy involving DFO. These findings will be beneficial for the development of novel cancer chemotherapeutics. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - May 12, 2022 Category: Cancer & Oncology Source Type: research
Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish
ConclusionsThese data indicate thatxmrk andMyc can temporally regulate lipid species that may serve as effective biomarkers of HCC progression. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 4, 2022 Category: Cancer & Oncology Source Type: research
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas
ConclusionsSTN and other clinically approved HMGCRi could be promising combinatorial agents for improving the efficacy of ETC inhibitors like IACS in BRAFi-resistant melanomas. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 22, 2022 Category: Cancer & Oncology Source Type: research
Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics
ConclusionsThese data suggest a potential role for the immune microenvironment in hyperinsulinemia-driven PanIN development. Together with our previous work, we propose that mild suppression of insulin levels may be useful in preventing pancreatic cancer by acting on multiple cell types. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 21, 2022 Category: Cancer & Oncology Source Type: research
Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells
ConclusionsFor the first time, we report a potential tumor suppressive role for glucagon/GCGR in liver cancer. Specifically, we identified a novel cell line-specific phenotype, whereby glucagon signaling can induce apoptosis via an undetermined mechanism. Future studies should explore the potential effects of glucagon in diabetic liver cancer patients. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - February 5, 2022 Category: Cancer & Oncology Source Type: research
