Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity

ConclusionsHere, we highlight the importance of understanding metabolism in non-obesity-associated cancers, such as melanoma. This work advances the understanding of the correlation between metabolism and immunogenicity in the tumor microenvironment and provides evidence supporting metabolic gene expression as potential prognostic factors of melanoma progression and may inform investigations of adjunctive metabolic therapy in melanoma.Trial registrationDeidentified data from The Cancer Genome Atlas were analyzed.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research