GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase

ConclusionsWe show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation. This indicates that fructose uptake is the limiting factor for fructose-mediated cell proliferation. We further demonstrate that cellular proliferation with fructose is independent of KHK.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research