Survey on Physicians ’ Knowledge and Training Needs in Genetic Counseling in Germany
Conclusion: The survey demonstrates a gap of genetic and risk literacy in a relevant proportion of physicians and the need for appropriate training concepts.Breast Care (Source: Breast Care)
Source: Breast Care - November 4, 2020 Category: Cancer & Oncology Source Type: research
Therapy Algorithms for the Diagnosis and Treatment of Patients with Early and Advanced Breast Cancer
Background: In order to offer optimal treatment approaches based on available evidence, the Commission Breast of the Working Group Gynecologic Oncology (AGO) of the German Cancer Society developed therapy algorithms for eight complex treatment situations in primary and advanced breast cancer.Summary: Therapy algorithms for the following complex treatment situations are outlined in this paper: (neo)adjuvant therapy of human epidermal growth factor receptor 2 (HER2)-positive breast cancer; axillary surgery and neoadjuvant chemotherapy; adjuvant endocrine therapy in premenopausal patients; adjuvant endocrine therapy in postme...
Source: Breast Care - November 2, 2020 Category: Cancer & Oncology Source Type: research
European Breast Cancer Conference 12, October 2 –3, 2020: Interview with the Chairs
Breast Care (Source: Breast Care)
Source: Breast Care - October 30, 2020 Category: Cancer & Oncology Source Type: research
Double Heterozygous Mutations in the < b > < i > BRCA2 < /i > < /b > and < b > < i > ATM < /i > < /b > Genes: A Case Report and Review of the Literature
Conclusion: Multiple primary malignant neoplasms can be encountered more frequently in DH pathogenic variant carriers, and the diagnosis of malignancies can be made at an earlier age through surveillance guided by genetic testing. In this rare case, more patient studies are needed to determine the contribution of DH inBRCA2 andATM genes to the phenotype.Breast Care (Source: Breast Care)
Source: Breast Care - October 29, 2020 Category: Cancer & Oncology Source Type: research
The Identification of Gene Expression Profiles Associated with Granulomatous Mastitis
Conclusion: This study is the first to use sequencing technology to elucidate the genetic mechanisms of GM. The finding of this study may have potential value in GM diagnosis and also provides potential drug targets for GM treatment.Breast Care (Source: Breast Care)
Source: Breast Care - October 29, 2020 Category: Cancer & Oncology Source Type: research
Punctual Breast Implant Rupture following Lipofilling: Only a Myth?
Conclusions: Punctual breast implant rupture is a possible complication of lipofilling that is usually not suspected at first consultation and might be underdiagnosed based on radiological findings, so investigating clinical signs should necessarily be a prerequisite to diagnosis.Breast Care (Source: Breast Care)
Source: Breast Care - October 28, 2020 Category: Cancer & Oncology Source Type: research
Biomarkers in Her2- Positive Disease
Background: Breast cancer is a heterogeneous disease with well-known characteristics such as hormone receptor (HR) status and human epidermal growth factor (Her)2 status. Although Her2 represents an established treatment target, the development of resistance mechanisms during treatment, cardiotoxicity, and a worse response to standard therapies lead to worse outcomes.Summary: Therefore, we investigated various biomarkers in breast cancer such as Her2 mutations, Her2 heterogeneity, HR, PIK3CA, PTEN, programmed death receptor ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TIL), micro RNA (miRNA), and BRCA mutations with r...
Source: Breast Care - October 28, 2020 Category: Cancer & Oncology Source Type: research
Early HER2-Positive Breast Cancer: Current Treatment and Novel Approaches
Background: Trastuzumab significantly improves outcomes in early HER2-positive breast cancer, irrespectively of any prognostic or predictive factors. Unfortunately, about a quarter of patients receiving neoadjuvant trastuzumab experience disease recurrence, revealing the unquestionable need for further improvement of treatment outcomes.Summary: Adding HER2 blockade to adjuvant trastuzumab with pertuzumab and neratinib improves invasive disease-free survival (IDFS), particularly for those at highest risk of recurrence. A shift toward a neoadjuvant strategy for patients with a higher risk of recurrence could result in furthe...
Source: Breast Care - October 28, 2020 Category: Cancer & Oncology Source Type: research
Understanding and Treating HER Better
Breast Care (Source: Breast Care)
Source: Breast Care - October 27, 2020 Category: Cancer & Oncology Source Type: research
Sexual Dysfunction in Postmenopausal Women with Breast Cancer on Adjuvant Aromatase Inhibitor Therapy
Conclusions: We observed a high prevalence of sexual inactivity among BC survivors regardless of AI use. Patients with AI use presented significantly higher prevalence of FSD, worse QoL, and greater anxiety.Breast Care (Source: Breast Care)
Source: Breast Care - October 23, 2020 Category: Cancer & Oncology Source Type: research
Management of Chemotherapy-Induced Nausea and Vomiting with Trastuzumab Deruxtecan: A Case Series
Conclusion: This review indicates that management of CINV for patients receiving trastuzumab deruxtecan should follow recommendations for regimens with a high-risk emetic potential.Breast Care (Source: Breast Care)
Source: Breast Care - October 23, 2020 Category: Cancer & Oncology Source Type: research
Targeting the Human Epidermal Growth Factor Receptor Family in Breast Cancer beyond HER2
Currently, the dichotomous definition of human epidermal growth factor receptor 2 (HER2)-positive versus HER2-negative disease undergoing a change through inclusion of the identification of the “HER2-low” category, for which new therapeutic compounds in the form of potent antibody drug conjugates (ADC) may be effective. In addition, resistance to HER2-directed targets has become a clinical challenge and, therefore, strategies to bypass the HER2 receptor are of high interest. These are new HER2 ADCs and tyrosine kinase inhibitors, such as tucatinib or neratinib. The underlying mechanisms of resistance to anti-HER2 thera...
Source: Breast Care - October 22, 2020 Category: Cancer & Oncology Source Type: research
PharmaNews
Breast Care 2020;15:553 –554 (Source: Breast Care)
Source: Breast Care - October 20, 2020 Category: Cancer & Oncology Source Type: research
Mammary Chain Irradiation in Left-Sided Breast Cancer: Can We Reduce the Risk of Secondary Cancer and Ischaemic Heart Disease with Modern Intensity-Modulated Radiotherapy Techniques?
Conclusion: Although IMC irradiation has been shown to increase survival rates in node-positive BC patients, it increased dose exposure of organs at risk in left-sided BC, resulting in significantly increased risks for secondary lung cancer/contralateral BC and ischaemic heart disease. In this setting, the adoption of IMRT seems advantageous when compared to 3D-CRT.Breast Care (Source: Breast Care)
Source: Breast Care - October 19, 2020 Category: Cancer & Oncology Source Type: research
Implant Replacement or Removal: What Happens after Capsular Contracture? A German Study Examining Breast Implant Revision Surgery and Patient Choices in 946 Cases
Conclusion: Significant differences are observed for reconstructive and aesthetic patients regarding indication leading to revision surgery, time of revision surgery, and the type of performed revision surgery itself. After implant removal, more than 60% of aesthetic patients undergo mastopexy, more than half of reconstructive patients choose autologous breast reconstruction, and over a quarter of patients choose no additional surgical procedures.Breast Care (Source: Breast Care)
Source: Breast Care - October 16, 2020 Category: Cancer & Oncology Source Type: research
