Fifteen Years of < b > < i > Breast Care < /i > < /b >
Breast Care (Source: Breast Care)
Source: Breast Care - March 26, 2021 Category: Cancer & Oncology Source Type: research
Luminal Metastatic Breast Cancer: Current Concepts and Future Approaches
Breast Care (Source: Breast Care)
Source: Breast Care - March 23, 2021 Category: Cancer & Oncology Source Type: research
Challenges and Opportunities for Real-World Evidence in Metastatic Luminal Breast Cancer
This article describes the PRAEGNANT network and sheds light on the question of whether the various end points from clinical trials can be transferred to the real-world treatment situation.Breast Care (Source: Breast Care)
Source: Breast Care - March 16, 2021 Category: Cancer & Oncology Source Type: research
Higher CD1a Levels Correlate with PD-L1 Expression and Predict Worse Overall Survival in Triple-Negative Breast Carcinoma
Conclusion: PD-L1, CD1a, and CD83 are variably expressed in triple-negative breast carcinoma tissues, and PD-L1 expression correlates with CD1a and CD83. Higher CD1a levels correlate with PD-L1 expression and predict worse OS in triple-negative breast carcinoma.Breast Care (Source: Breast Care)
Source: Breast Care - March 15, 2021 Category: Cancer & Oncology Source Type: research
First Experiences with Alpelisib in Clinical Routine: Case Reports from a German Breast Center
Conclusion: Patient education and a well-trained, interdisciplinary team including diabetologists, from the initiation of alpelisib treatment onwards, are essential to safely treat ABC patients with this new drug and to maintain their quality of life and ensure their survival.Breast Care (Source: Breast Care)
Source: Breast Care - March 15, 2021 Category: Cancer & Oncology Source Type: research
The < b > < i > CHEK2 < /i > < /b > *1100delC Mutation and Adolescent Breast Cancer: A Case Report of Breast Cancer in a 19-Year-Old and a Review of the Literature
Background: Breast cancer (BC) is the most common non-skin cancer affecting women but is extremely uncommon in the adolescent population. Genetic inheritance has been linked to #x3c;10% of BCs.CHEK2 is an uncommon genetic variant with a reported incidence of 0.3 –1.6% in the general population and 4.9–5.7% in those with a family history of BC. Commonly, this mutation presents in females of European descent and is rare in North America.Case Presentation: A 19-year-old Caucasian female presented with breast pain and mass. She had an extensive family history of cancer, as well as a knownCHEK2 gene mutation in 2 of her pat...
Source: Breast Care - March 8, 2021 Category: Cancer & Oncology Source Type: research
Adjuvant Treatment of Elderly Breast Cancer Patients: Offer the Best Chances of Cure
Background: Breast cancer remains the most common cancer in women and a leading cause of death. Elderly people have a higher incidence of breast cancer since it increases with age. Furthermore, the extended life expectancy and advances in imaging techniques have led to an increased number of cases. Guidelines concerning the management of this specific age group are rare, mainly due to underrepresentation of seniors in clinical trials. Moreover, increased frailty, comorbidities, and a poor performance status make it complex to determine the best therapeutic approach.Summary: In this review, we attempt to summarize the curre...
Source: Breast Care - March 4, 2021 Category: Cancer & Oncology Source Type: research
Is Anti-M üllerian Hormone a Marker of Ovarian Reserve in Young Breast Cancer Patients Receiving a GnRH Analog during Chemotherapy?
Conclusions: This study did not reach its principal endpoint; however, the rate of 48% of patients who recovered AMH above threshold levels favorably compared with those in studies without concurrent GnRHa, supporting a better recovery of AMH with triptorelin.Breast Care (Source: Breast Care)
Source: Breast Care - March 4, 2021 Category: Cancer & Oncology Source Type: research
Oncoplastic Level II Surgical Techniques for Breast Cancer Treatment: Long-Term Outcomes
Conclusion: Level II OPS techniques have low reoperation and complication rates and a high rate of breast protection. The success of these techniques has been demonstrated in terms of long-term local control. Awareness of the fact that many patients who undergo OPS will not lose their breasts should be created, and regular training programs for OPS techniques should be conducted especially in developing countries. By revealing these results, it is hoped that the OPS and breast conservation rates will increase.Breast Care (Source: Breast Care)
Source: Breast Care - March 1, 2021 Category: Cancer & Oncology Source Type: research
Effects of Diet after Early Breast Cancer Treatment: A Systematic Review and Meta-Analysis of Clinical Trials
Conclusions: Despite increasing survival among breast cancer patients due to better oncological treatments, there is still a lack of prospective data regarding the effects of dietary interventions in this population. We found positive association between prescription of specific diets in terms of anthropometric measures; there were no differences in OS or DFS.Breast Care (Source: Breast Care)
Source: Breast Care - February 25, 2021 Category: Cancer & Oncology Source Type: research
Treatment of Luminal Metastatic Breast Cancer beyond CDK4/6 Inhibition: Is There a Standard of Care in Clinical Practice?
Conclusion: Potential subsequent therapies include PI3K inhibitors, mTOR inhibitors, endocrine monotherapy, PARP inhibitors, and chemotherapy. However, these therapies have mainly been developed in the pre-CDK4/6 inhibitor era and little is known about potential cross-resistance. The concept of continuing CDK4/6 inhibition beyond progression is supported by some preclinical data, but to date there is very limited clinical evidence to support this strategy. Therefore, treatment of metastatic luminal breast cancer after progression on CDK4/6 inhibitors remains a challenge.Key Messages: Here we review current evidence from pr...
Source: Breast Care - February 24, 2021 Category: Cancer & Oncology Source Type: research
Diffusion-Weighted Imaging of Different Breast Cancer Molecular Subtypes: A Systematic Review and Meta-Analysis
Conclusions: ADC values cannot be used to discriminate between molecular subtypes of BC.Breast Care (Source: Breast Care)
Source: Breast Care - February 23, 2021 Category: Cancer & Oncology Source Type: research
Awareness and Availability of Routine Germline < b > < i > BRCA1/2 < /i > < /b > Mutation Testing in Patients with Advanced Breast Cancer in Germany
Conclusion: Diagnostic gBRCA1/2 mutation testing in patients with HER2 – ABC is available and routinely performed in Germany’s outpatient oncology setting. However, specific patient subgroups were not routinely tested despite therapeutic indications. Given PARPi availability, opportunities exist to improve testing rates especially for patients with HR+/HER2– ABC without a known family history of gBRCA1/2 mutation-related cancer(s).Breast Care (Source: Breast Care)
Source: Breast Care - February 18, 2021 Category: Cancer & Oncology Source Type: research
Treatments for Periductal Mastitis: Systematic Review and Meta-Analysis
Conclusion: Breast duct irrigation, which is the most minimally invasive of all of the treatment options, seemed to yield good outcomes and may be the first-line treatment for PDM patients. Minor excision methods, except for primary closure alone, might be enough for most PDM patients. Major excision, especially with radial incision, was a highly effective salvage therapy. The major plastic surgery technique was also acceptable as an alternative treatment for patients with large lesions and concerns about breast appearance. Incision and drainage and minor excision with primary closure alone should be avoided for PDM patien...
Source: Breast Care - February 18, 2021 Category: Cancer & Oncology Source Type: research
Selective Extirpation of Tattooed Lymph Node in Combination with Sentinel Lymph Node Biopsy in the Management of Node-Positive Breast Cancer Patients after Neoadjuvant Systemic Therapy
Conclusion: Lymph node marking with carbon dye is a useful and cost-effective method, which can be successfully implemented in order to reduce the number of patients undergoing axillary dissection. Low specificity of the presented algorithm was caused mostly by the overestimation of residual axillary disease on ultrasound.Breast Care (Source: Breast Care)
Source: Breast Care - February 17, 2021 Category: Cancer & Oncology Source Type: research
