De-Escalating Axillary Surgery in Node-Positive Breast Cancer Treated with Neoadjuvant Systemic Therapy
This article provides an overview of the literature on currently used less invasive axillary staging procedures, the accuracy and feasibility of these procedures in clinical practice, important issues concerning axillary treatment, and issues to be addressed in ongoing or future studies.Key messages: More evidence is needed regarding the safety of replacing standard ALND by less invasive axillary staging procedures in terms of long-term prognosis. These less invasive staging procedures not only serve to select patients who may benefit from treatment de-escalation, but also to select patients who may benefit from treatment ...
Source: Breast Care - August 17, 2021 Category: Cancer & Oncology Source Type: research
Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors
Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increa...
Source: Breast Care - August 12, 2021 Category: Cancer & Oncology Source Type: research
Risk Factors for Idiopathic Granulomatous Mastitis Recurrence after Patient-Tailored Treatment: Do We Need an Escalating Treatment Algorithm?
Conclusion: Describing a low-risk patient profile can be an alternative while choosing monotherapy methods. For IGM patients at high risk of recurrence, an escalating treatment system may be effective in preventing relapses.Breast Care (Source: Breast Care)
Source: Breast Care - August 10, 2021 Category: Cancer & Oncology Source Type: research
Expert Discussion: ASCO 2021
Breast Care (Source: Breast Care)
Source: Breast Care - July 23, 2021 Category: Cancer & Oncology Source Type: research
Consensus Recommendations of the German Consortium for Hereditary Breast and Ovarian Cancer
Background: The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has established a multigene panel (TruRisk ®) for the analysis of risk genes for familial breast and ovarian cancer.Summary: An interdisciplinary team of experts from the GC-HBOC has evaluated the available data on risk modification in the presence of pathogenic mutations in these genes based on a structured literature search and through a formal consensus process.Key Messages: The goal of this work is to better assess individual disease risk and, on this basis, to derive clinical recommendations for patient counseling and care at the cen...
Source: Breast Care - July 19, 2021 Category: Cancer & Oncology Source Type: research
Influence of Breast Reduction Surgery on Long-Term Breast Cancer Risk in Austria
Discussion: Our study underlines the strong evidence of previous studies for significant breast cancer reduction in patients after reductive mammoplasty. In comparison to the general female population of Austria, our cohort showed a reduction in breast cancer incidence of about 82%. The authors believe that different techniques in reduction mammoplasty have different levels of safety regarding the prevention and risk reduction for breast cancer. Further investigation must be conducted to evaluate the reduction of breast cancer risk with different surgical techniques.Breast Care (Source: Breast Care)
Source: Breast Care - July 15, 2021 Category: Cancer & Oncology Source Type: research
Factors Indicating Surgical Excision in Classical Type of Lobular Neoplasia of the Breast
Conclusions: Surveillance or subsequent VAB after CNB of LN is sufficient in most cases. Careful consideration of individual radiological and histological factors is required to identify patients with a high risk of upgrade into malignancy. In those cases, surgical excision is indicated.Breast Care (Source: Breast Care)
Source: Breast Care - July 7, 2021 Category: Cancer & Oncology Source Type: research
First-Line Efficacy of Anti-HER2 Treatments in Previously Treated HER2-Positive Metastatic Breast Cancer Patients: A Retrospective Observational Study Investigating the Efficacy of Re-Exposure to Anti-HER2 Therapy for HER2-Positive Metastatic Breast Cancer Patients in Comparison with Na ïve Patients
Conclusion: Our analysis suggests that previous exposure to anti-HER2 agents might influence the clinical outcome of first-line treatment in metastatic HER2 patients. These findings justify further exploration of the benefit of reintroduction of anti-HER2 treatment enabling the optimal treatment for patients with previous anti-HER2 therapy exposure.Breast Care (Source: Breast Care)
Source: Breast Care - July 7, 2021 Category: Cancer & Oncology Source Type: research
Malignancy Rate and Malignancy Risk Assessment in Different Lesions of Uncertain Malignant Potential in the Breast (B3 Lesions): An Analysis of 192 Cases from a Single Institution
Conclusion: Increasing knowledge about B3 lesions allows us to develop a “lesion-specific” therapy approach in the heterogeneous group of B3 lesions, with follow-up imaging for some lesions with less malignant potential and concordance with imaging or further surgical resection in cases of disconcordance with imaging or higher malignant potential.Breast Care (Source: Breast Care)
Source: Breast Care - July 1, 2021 Category: Cancer & Oncology Source Type: research
Targeted Axillary Dissection after Chemotherapy: Feasibility Study with Clip and Carbon Dye Tattoo – Neotarget Trial
Conclusions: The introduction of double marking by clipping the metastatic node and verifying their removal by surgical specimen radiography, using carbon ink as a tracer, allowed the identification of the metastatic node in 94% of cases, with a simple, reproducible, and easy-to-implement targeted axillary dissection procedure.Breast Care (Source: Breast Care)
Source: Breast Care - June 30, 2021 Category: Cancer & Oncology Source Type: research
Recommendation and Acceptance of Counselling for Familial Cancer Risk in Newly Diagnosed Breast Cancer Cases
Conclusion: Acceptance of recommendation is increasing as clinical consequences augment. Optimization in providing information about hereditary cancer risk and in accessibility of counselling and testing is required to further improve acceptance of recommendation.Breast Care (Source: Breast Care)
Source: Breast Care - June 17, 2021 Category: Cancer & Oncology Source Type: research
Expert Discussion: HER2-Positive Breast Cancer
Breast Care (Source: Breast Care)
Source: Breast Care - June 17, 2021 Category: Cancer & Oncology Source Type: research
PharmaNews
Breast Care 2021;16:315 –318 (Source: Breast Care)
Source: Breast Care - June 11, 2021 Category: Cancer & Oncology Source Type: research
Junge Patientinnen mit fr ühem HER2-positivem Brustkrebs
Breast Care 2021;16:312 –314 (Source: Breast Care)
Source: Breast Care - June 11, 2021 Category: Cancer & Oncology Source Type: research
Genetic Testing in Breast Cancer: New Standards of Care
Breast Care (Source: Breast Care)
Source: Breast Care - June 2, 2021 Category: Cancer & Oncology Source Type: research
