Luminal Breast Cancer: The Head of Janus in Breast Oncology
Breast Care (Source: Breast Care)
Source: Breast Care - August 4, 2020 Category: Cancer & Oncology Source Type: research
Endocrine-Resistant Breast Cancer: Mechanisms and Treatment
Background: Endocrine treatment is one of the most effective therapies for estrogen receptor-positive breast cancer. However, most tumors will develop resistance to endocrine therapy as the cancer progresses. This review focuses on the mechanisms and markers of endocrine-resistant breast cancer. In addition, current and future strategies to overcome endocrine resistance are discussed.Summary: Several molecular mechanisms of endocrine resistance have been identified, including alterations in the ESR1 gene or in the PIK3CA/mTOR pathway. Meanwhile, CDK4/6, mTOR, and PI3K inhibition have shown to improve the efficacy of endocr...
Source: Breast Care - July 29, 2020 Category: Cancer & Oncology Source Type: research
Virtual Science in Senology: Let Us Not Throw out the Baby with the Bathwater
Breast Care (Source: Breast Care)
Source: Breast Care - July 28, 2020 Category: Cancer & Oncology Source Type: research
Genomic Signatures in Luminal Breast Cancer
Background: Breast cancer is a very heterogeneous disease and luminal breast carcinomas represent the hormone receptor-positive tumors among all breast cancer subtypes. In this context, multigene signatures were developed to gain further prognostic and predictive information beyond clinical parameters and traditional immunohistochemical markers.Summary: For early breast cancer patients these molecular tools can guide clinicians to decide on the extension of endocrine therapy to avoid over- and undertreatment by adjuvant chemotherapy. Beside the predictive and prognostic value, a few genomic tests are also able to provide i...
Source: Breast Care - July 21, 2020 Category: Cancer & Oncology Source Type: research
Endocrine Therapy in Early Breast Cancer
Background: Endocrine therapy with a standard duration of 5 years is well known as an effective treatment for endocrine-sensitive breast cancer.Summary: In the adjuvant setting this treatment reduces the 15-year mortality rates by about 30 and 40% with tamoxifen and aromatase inhibitor, respectively. The well-known long-term recurrence risk of luminal cancers led to multiple trials examining the benefit of extended endocrine treatment for up to 15 years. Additional benefit with extended therapy was seen for patients with high recurrence risk. Also, additional ovarian suppression for premenopausal women exhibited a signific...
Source: Breast Care - July 21, 2020 Category: Cancer & Oncology Source Type: research
Oncoplastic Surgery in Breast-Conserving Treatment: Patient Profile and Impact on Quality of Life
Conclusion: Despite the fact that OS was performed in patients with worse tumour conditions and in more demanding patients, OS allowed similar cosmetic results to classical BCT.Breast Care (Source: Breast Care)
Source: Breast Care - July 17, 2020 Category: Cancer & Oncology Source Type: research
Asco 2020
Breast Care (Source: Breast Care)
Source: Breast Care - July 16, 2020 Category: Cancer & Oncology Source Type: research
Histology of Luminal Breast Cancer
Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological features.Summary: IBC of no special subtype is the most common histological subtype in general and likewise within luminal IBC. Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular...
Source: Breast Care - July 15, 2020 Category: Cancer & Oncology Source Type: research
Treating Positive Axillary Disease in Elderly Breast Cancer Patients: The Impact of Age on Radiation Therapy
Conclusion: Patient age has a significant influence if elderly patients with axillary disease receive radiotherapy. Further investigation and validation are needed to understand why chronological age rather than biological age influences treatment modalities.Breast Care (Source: Breast Care)
Source: Breast Care - July 13, 2020 Category: Cancer & Oncology Source Type: research
Ribociclib-Induced Pneumonitis: A Case Report
Discussion: Lung injury is a possible side effect of CDK 4/6 inhibitors and there is an increasing need to understand the management of this side effect.Breast Care (Source: Breast Care)
Source: Breast Care - July 8, 2020 Category: Cancer & Oncology Source Type: research
Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy
Conclusions: In this retrospective analysis, family history was not associated with pCR and DFS. pCR improved survival, independently of family history.Breast Care (Source: Breast Care)
Source: Breast Care - July 1, 2020 Category: Cancer & Oncology Source Type: research
A Novel First-Line Treatment Alternative for Noncomplicated İdiopathic Granulomatous Mastitis: Combined İntralesional Steroid İnjection with Topical Steroid Administration
Conclusion: Based on the results of our study, combined steroid injection and topical steroid treatment in IGM is as effective as systemic steroid treatment. We suggest that this combination therapy of topical steroids and local steroid injection should be used as first-line therapy in patients with noncomplicated IGM.Breast Care (Source: Breast Care)
Source: Breast Care - June 30, 2020 Category: Cancer & Oncology Source Type: research
A Giant Mammary Hamartoma in a Young Breast Cancer Patient
Conclusion: We presented the rare case of a 36-year-old woman with a history of breast cancer and a 700-g breast hamartoma. The preoperative and even the postoperative specification of a hamartoma remains challenging, and associations with genetic alterations should be considered.Breast Care (Source: Breast Care)
Source: Breast Care - June 24, 2020 Category: Cancer & Oncology Source Type: research
Value of Conventional MRI Texture Analysis in the Differential Diagnosis of Phyllodes Tumors and Fibroadenomas of the Breast
Conclusion: Texture analysis of conventional MRI can be used as an assistant tool in providing a certain objective basis for differentiating PTs from FAs.Breast Care (Source: Breast Care)
Source: Breast Care - June 23, 2020 Category: Cancer & Oncology Source Type: research
Does Internal Mammary Node Irradiation for Breast Cancer Make a Significant Difference to the Diameter of the Internal Mammary Artery? Correlation with Computed Tomography
Conclusions: The diameter of the IMA is decreased due to RT regardless of laterality, radiation technique, and administration of a boost dose. Evaluation of vessels on CT before coronary artery bypass graft or flap reconstruction can help the surgeon select the most appropriate vessel.Breast Care (Source: Breast Care)
Source: Breast Care - June 22, 2020 Category: Cancer & Oncology Source Type: research
