Magnetic Seed (Magseed) Localisation in Breast Cancer Surgery: A Multicentre Clinical Trial
Conclusion: Magseed is a reliable marker for breast tumour and pathological axillary node localisation in breast cancer patients. Magseed is comparable to conventional localisation methods in terms of oncosurgical radicality and safety.Breast Care (Source: Breast Care)
Source: Breast Care - October 14, 2020 Category: Cancer & Oncology Source Type: research
Clinical Data on Immunotherapy in Breast Cancer
Background: Breast cancer has traditionally been considered to have a low immunogenic potential compared to other tumor entities.Summary: The most extensively studied immunotherapeutic agents for breast cancer to date are immune checkpoint inhibitors, with the results of the IMpassion130 trial leading to the approval of atezolizumab plus nab-paclitaxel for first-line treatment of programmed cell death ligand 1-positive, metastatic, triple-negative breast cancer, and studies in earlier stages have yielded promising results. Other immunotherapeutic options being assessed in phases 2 and 3 trials include vaccine-based therapi...
Source: Breast Care - October 13, 2020 Category: Cancer & Oncology Source Type: research
Management of Breast Cancer Patients during the COVID-19 Pandemic in Northern Italy
Breast Care (Source: Breast Care)
Source: Breast Care - October 8, 2020 Category: Cancer & Oncology Source Type: research
Liquid Biopsies to Evaluate Immunogenicity of Gynecological/Breast Tumors: On the Way to Blood-Based Biomarkers for Immunotherapies
Background: Despite the assumption of breast cancer (BC) as a cold, non-immunogenic tumor, immune checkpoint inhibitor (ICI) therapy is favorable for a subgroup of patients. Immunohistochemical assessment of the programmed cell death ligand 1 (PD-L1) is the only approved companion diagnostic for anti-PD-L1 therapy in metastatic triple-negative BC; however, challenges regarding the standardization of PD-L1 scoring in tumor tissue still remain. Consequently, to select patients most likely to respond to ICI, blood-based biomarkers are urgently needed.Summary and Key Messages: Liquid biopsy, comprising circulating immune cells...
Source: Breast Care - October 7, 2020 Category: Cancer & Oncology Source Type: research
The Abscopal Effect: Could a Phenomenon Described Decades Ago Become Key to Enhancing the Response to Immune Therapies in Breast Cancer?
Background: The term “abscopal effect” was defined in 1953. In oncology the term is used to describe systemic antitumor effects triggered by local irradiation (nontarget effect). Although the mechanism of the abscopal effect is not completely understood yet, it has been demonstrated that in situ tumor vaccination, a nd the resulting antitumor immune response, is one of the key factors.Summary: The development of immune therapies has recently led to concepts combining local radiotherapy and immune therapy with the aim of enhancing the response to immune therapy by the immunological mechanisms summarized in the term absc...
Source: Breast Care - October 6, 2020 Category: Cancer & Oncology Source Type: research
Understanding PD-L1 Testing in Breast Cancer: A Practical Approach
Background: Immune checkpoint inhibitors (ICI) have changed therapy strategies for cancer patients tremendously. Some approved ICI acquire testing of PD-L1 expression on tumor and/or immune cells. However, since PD-L1 testing is a comprehensive issue with various assays, antibody clones, scoring methods, and cut-offs, we aimed to summarize the recommendations and technical and histopathological issues of diagnostic PD-L1 assessment with an emphasis on invasive breast cancer (IBC).Summary: Besides other (pre)analytical considerations, selecting the most adequate PD-L1 immunohistochemical assay/antibody clone is important. I...
Source: Breast Care - October 6, 2020 Category: Cancer & Oncology Source Type: research
Late Presentation at Primary Diagnosis of Breast Cancer: Patients ’ Personality Characteristics and Attitudes
Conclusion: As patients with late presentation for BC differ in specific psychological and sociodemographic characteristics from patients with early BC, the findings of this pilot project warrant additional investigations to identify further specific characteristics and motivations. Identifying patients at risk for late presentation and encouraging them to accept an earlier diagnosis could help to improve their therapy and, finally, their outcome.Breast Care (Source: Breast Care)
Source: Breast Care - September 21, 2020 Category: Cancer & Oncology Source Type: research
Real-World Efficacy of Fulvestrant Monotherapy as the First Treatment or Maintenance Treatment in Patients with Metastatic Breast Cancer
Conclusions: Fulvestrant monotherapy showed good clinical activity and safety in patients with MBC who were treated upon disease progression and in those receiving maintenance therapy.Breast Care (Source: Breast Care)
Source: Breast Care - September 18, 2020 Category: Cancer & Oncology Source Type: research
Patient-Reported Outcomes and Aesthetic Results after Immediate Breast Reconstruction Using Human Acellular Dermal Matrices: Results of a Multicenter, Prospective, Observational NOGGO-AWOGyn Study
Conclusion: The level of satisfaction among patients and surgeons and the score of the aesthetic result were constantly high among patients after ADM-assisted IBBR. Higher satisfaction scores could be observed after revision surgery caused by capsular fibrosis (cohort B) compared to primary reconstruction (cohort A). Quality of life increased during the first year after surgery.Breast Care (Source: Breast Care)
Source: Breast Care - September 16, 2020 Category: Cancer & Oncology Source Type: research
Prognostic Roles of Neutrophil-to-Lymphocyte Ratio and Stromal Tumor-Infiltrating Lymphocytes and Their Relationship in Locally Advanced Triple-Negative Breast Cancer Treated with Neoadjuvant Chemotherapy
Conclusion: Low NLR1 and high sTILs were associated with better DFS outcome in locally advanced TNBC patients treated with NAC. Further studies are needed to explore the connection between systemic and local inflammatory/immune markers.Breast Care (Source: Breast Care)
Source: Breast Care - September 4, 2020 Category: Cancer & Oncology Source Type: research
Identification of a Prognostic Signature Based on the Expression of Genes Related to the Insulin Pathway in Early Breast Cancer
Conclusions: Our findings indicate that the insulin pathway is involved in BC prognosis at a genomic level and provide a window of selectivity for preventive and treatment strategies targeting the insulin/IGF pathway in BC patients.Breast Care (Source: Breast Care)
Source: Breast Care - August 28, 2020 Category: Cancer & Oncology Source Type: research
PharmaNews
Breast Care 2020;15:440 –440 (Source: Breast Care)
Source: Breast Care - August 21, 2020 Category: Cancer & Oncology Source Type: research
Post-neoadjuvante Behandlung fr üher HER2-positiver Mammakarzinome
Breast Care 2020;15:439 –439 (Source: Breast Care)
Source: Breast Care - August 21, 2020 Category: Cancer & Oncology Source Type: research
Radiotherapy-Induced Fatigue in Breast Cancer Patients
Background: A large proportionof breast cancer patients who undergo adjuvant radiotherapy suffer from radiotherapy-induced fatigue. The possible causative factors of this specific side effect are diverse.Summary: Prevalence, duration, and severity of radiotherapy-induced fatigue are dependent on the type of radiotherapy, as well as on the irradiated volume, dose scheme, on the number of radiation fields, the combination with other treatments, diurnal rhythm, smoking, and time-to-hospitalization. Recommended treatments include non-pharmacologic interventions, such as physical and psychosocial interventions. Pharmacologic th...
Source: Breast Care - August 14, 2020 Category: Cancer & Oncology Source Type: research
Analysis of Oncological Second Opinions in a Certified University Breast and Gynecological Cancer Center Regarding Consensus between the First and Second Opinion and Conformity with the Guidelines
Conclusions: Oncological second opinions showed significant effects and one-third of first opinions were not in conformity with the guidelines. In a significant proportion of cases, the existing treatment plan was changed or supplemented to allow modern and individualized treatment approaches.Breast Care (Source: Breast Care)
Source: Breast Care - August 5, 2020 Category: Cancer & Oncology Source Type: research
